Arrowhead Pharma Stock Price, News & Analysis

Arrowhead Pharmaceuticals (NASDAQ: ARWR) recently announced interim results from its ongoing Phase 1/2 study of ARO-RAGE, an RNA interference therapeutic aimed at treating inflammatory pulmonary diseases like asthma. The study reported a mean maximum reduction of 80% in serum soluble RAGE (sRAGE) levels after two doses, with some patients experiencing reductions of up to 90%. The pharmacologic effect lasted at least 6 weeks following the 92 mg dose. No serious adverse events were reported, indicating promising safety and tolerability. Data from the study will be further presented at the upcoming R&D Day on June 1, 2023. This represents a significant step for Arrowhead's therapeutic pipeline, showcasing the potential of its proprietary TRiM platform.

Arrowhead Pharmaceuticals (NASDAQ: ARWR) will host a webcast and conference call on May 2, 2023, at 4:30 p.m. ET to discuss its financial results for the fiscal 2023 second quarter ended March 31, 2023. Investors can access the live webcast on the Company's website, with a replay available two hours after the call. The company is known for developing RNA interference-based medicines targeting intractable diseases through innovative gene-silencing technologies. Details of the call can be found on their investor relations page.

Arrowhead Pharmaceuticals (NASDAQ: ARWR) will host a Research & Development Day on June 1, 2023, at 9 a.m. ET in New York City. The event will focus on the company's aim to expand its RNAi therapeutics pipeline to 20 clinical products by 2025. Key advancements include the expanded TRiM platform for central nervous system (CNS) delivery, particularly the ARO-SOD1 candidate, targeting ALS linked to SOD1 mutations, with a CTA filing expected by Q3 2023. The R&D Day will feature expert presentations on cardiometabolic and pulmonary diseases, and updates on various clinical programs, including ARO-APOC3 and ARO-ANG3. Attendance is limited, and registration is required.

Arrowhead Pharmaceuticals (NASDAQ: ARWR) announced the dosing of the first patient in Takeda’s Phase 3 REDWOOD study for fazirsiran (TAK-999/ARO-AAT), targeting alpha-1 antitrypsin deficiency-associated liver disease (AATD-LD). This event unlocks a $40 million milestone payment from Takeda to Arrowhead. Fazirsiran, an investigational RNA interference therapy, aims to reduce the production of the harmful Z-AAT protein. The study, involving 160 patients, evaluates the drug's efficacy and safety. Fazirsiran has previously received Breakthrough and Orphan Drug Designations from the FDA.

Arrowhead Pharmaceuticals (NASDAQ: ARWR) has achieved a $30 million milestone from GSK (LSE/NYSE: GSK) following the initiation of GSK4532990's Phase 2b trial for treating non-alcoholic steatohepatitis (NASH). This investigational RNA interference therapeutic was licensed to GSK in November 2021, with Arrowhead retaining rights for Greater China. The trial, known as HORIZON (NCT05583344), will assess the drug's efficacy and safety in up to 246 participants with pre-cirrhotic NASH. GSK4532990 targets HSD17B13, a gene linked to metabolic protection against NASH.

Arrowhead Pharmaceuticals (NASDAQ: ARWR) announced on March 29, 2023, that its Compensation Committee approved inducement grants for 31 new employees, totaling up to 46,050 restricted stock units. These grants, which incentivize new hires, are outside the company’s stockholder-approved equity incentive plans and will vest over four years. Arrowhead specializes in developing RNA interference-based therapeutics that target intractable diseases by silencing specific genes. This strategic move aims to attract talent to enhance its research and development efforts in RNAi-based medicines.

Arrowhead Pharmaceuticals (NASDAQ: ARWR) has received Fast Track designation from the FDA for its investigational therapy ARO-APOC3, aimed at reducing triglycerides in patients with familial chylomicronemia syndrome (FCS). This designation facilitates a faster development process and offers benefits such as priority review and accelerated approval. ARO-APOC3 targets apolipoprotein C-III (APOC3) and is currently being assessed in multiple clinical trials, including Phase 3 and Phase 2 studies for FCS and other conditions. There are currently no approved therapies for FCS, underscoring the significance of this treatment.