Welcome to our dedicated page for Alterity Therapeutics news (Ticker: ATHE), a resource for investors and traders seeking the latest updates and insights on Alterity Therapeutics stock.
Alterity Therapeutics Limited develops treatments for neurodegenerative diseases, with a clinical program centered on Multiple System Atrophy and related Parkinsonian disorders. News about ATHE commonly covers ATH434, its lead MSA candidate, Phase 2 analyses, FDA interactions, chemistry, manufacturing and control updates, and presentations at neurology and imaging conferences.
Coverage also includes bioMUSE Natural History Study biomarker work, including quantitative susceptibility mapping MRI for iron dysregulation in MSA, Appendix 4C cash flow and corporate updates, board appointments, and discussions of the company’s drug discovery platform for patentable chemical compounds targeting neurological disease pathology.
Alterity Therapeutics (NASDAQ: ATHE) announced two new preclinical studies showcasing the efficacy of ATH434 in treating Parkinsonian disorders. These studies published in the Journal of Parkinson's Disease and Plos One highlight the potential of ATH434 to alleviate gastrointestinal complications associated with Parkinson's disease by reversing colonic dysfunction and modulating iron trafficking. CEO David Stamler emphasized ATH434's promise in enhancing patient quality of life and mentioned ongoing preclinical studies aimed at advancing its clinical development.
Alterity Therapeutics Limited (ASX: ATH, NASDAQ: ATHE) provided an update on its clinical programs and financials for Q1 FY22, ending September 30, 2021. The company reported a cash balance of A$41.3M and a quarterly cash outflow of A$4.9M, consistent with ongoing clinical activities. Key highlights include advancements in the ATH434 Phase 2 trial for Multiple System Atrophy (MSA) and the expansion of its bioMUSE study, which aims to refine patient selection for therapies. Intellectual property have seen significant growth, enhancing future opportunities.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) has announced an expansion of the Phase 2 clinical trial for ATH434 targeting Multiple System Atrophy (MSA), a rare neurodegenerative disorder. The double-blind, placebo-controlled study will assess ATH434's effects on biomarkers related to α-synuclein aggregation and iron levels over 12 months across 30 sites in Australia, New Zealand, Europe, and the U.S. Additionally, the bioMUSE study will expand to 20 patients, enhancing data for the trial. ATH434 has Orphan designation and aims to improve the quality of life for MSA patients.
Alterity Therapeutics (NASDAQ: ATHE) reported progress in its biomarker study, bioMUSE, for early Multiple System Atrophy (MSA) patients. Data presented at the International Parkinson and Movement Disorder Society Congress 2021 highlighted the identification of iron accumulation in the brain as a potential biomarker for MSA. This could enhance patient selection for the upcoming Phase 2 trial of ATH434, aimed at treating MSA. The ongoing study is vital for understanding disease progression in MSA, which currently has no approved therapies.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) announced a Notice of Allowance from the USPTO for its patent application No. 17/239,375, securing exclusivity for a new group of iron chaperones aimed at addressing neurodegenerative diseases like Alzheimer's and Parkinson's. This patent covers over 80 novel compounds and follows the recent grant of another patent for 150 additional compounds. The company plans to advance its lead clinical asset, ATH434, into a Phase 2 trial, targeting Multiple System Atrophy and other conditions, while benefiting from approximately 20 years of patent exclusivity.
Alterity Therapeutics reported positive guidance from the European Medicines Agency for its ATH434 Phase 2 clinical trial in treating Multiple System Atrophy (MSA). During Q4 FY21, the company ended with a cash balance of A$28M, bolstered by $17M proceeds from an equity facility. An independent study published in Movement Disorders confirmed ATH434's neuroprotective effects in MSA models. The company aims to commence its clinical trial by year-end 2021, following progress in its natural history study underway at Vanderbilt University.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) announced study results showing that ATH434 can reduce α–synuclein related neurodegeneration in a murine model of Multiple System Atrophy (MSA). Published in Movement Disorders, the study found that ATH434 preserves neurons and enhances motor functions. The company plans to initiate a Phase 2 clinical trial by year-end. MSA, affecting about 15,000 patients in the U.S., currently has no approved therapy, making ATH434 a potential breakthrough treatment.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) announced the granting of a new composition of matter patent from the USPTO, covering a class of iron chaperones aimed at redistributing excess iron in the central nervous system. This patent secures a monopoly over 150 pharmaceutical compositions targeting neurodegenerative diseases such as Alzheimer's and Parkinson's. The company plans to launch a Phase 2 trial for its lead candidate, ATH434, by year-end, which is developed for Multiple System Atrophy (MSA) and is expected to advance their drug development efforts.
Alterity Therapeutics has received positive guidance from the European Medicines Agency (EMA) for its Phase 2 clinical trial of ATH434 targeting Multiple System Atrophy (MSA). The EMA supports recruiting early-stage MSA patients and the use of biomarkers to identify them. Alterity aims to utilize the EMA's feedback to improve trial design, aiming to generate robust data for regulatory authorities. The trial is set to launch in the second half of the year, focusing on a disease modifying approach as no approved treatment currently exists for MSA.
Alterity Therapeutics Limited (NASDAQ: ATHE) reported a cash balance of $32.8M for Q3 FY21, with operational cash outflows of $5M. The company received a $495K grant from the Michael J. Fox Foundation for Parkinson's disease research related to its lead drug candidate, ATH434. Progress continues on the Phase 2 trial for ATH434, with 80% of the target population recruited in a related study at Vanderbilt University. Dr David Stamler was appointed CEO, succeeding Geoffrey Kempler.