Alterity Therapeutics Limited develops treatments for neurodegenerative diseases, with a clinical program centered on Multiple System Atrophy and related Parkinsonian disorders. News about ATHE commonly covers ATH434, its lead MSA candidate, Phase 2 analyses, FDA interactions, chemistry, manufacturing and control updates, and presentations at neurology and imaging conferences.
Coverage also includes bioMUSE Natural History Study biomarker work, including quantitative susceptibility mapping MRI for iron dysregulation in MSA, Appendix 4C cash flow and corporate updates, board appointments, and discussions of the company’s drug discovery platform for patentable chemical compounds targeting neurological disease pathology.
Alterity Therapeutics (NASDAQ: ATHE) announced a new publication in Metallomics journal highlighting ATH434's unique mechanism as an iron chaperone for treating neurodegenerative diseases. The study demonstrates how ATH434 targets excess reactive iron, which is implicated in conditions like Friedreich's Ataxia, Parkinson's disease, and multiple system atrophy (MSA). Unlike traditional iron chelators, ATH434 shows lower affinity for ferric iron and reversible binding, allowing it to redistribute excess reactive iron without disrupting normal iron functions or generating harmful free radicals.
Alterity Therapeutics reported Q1 FY25 results with key developments in its ATH434 clinical trials. The company highlighted positive interim data from ATH434-202 Phase 2 trial in advanced MSA patients, suggesting potential disease-modifying effects. The ATH434-201 Phase 2 trial in early-stage MSA remains on track for topline data release in January 2025. Multiple data presentations were made at the International Congress of Parkinson's Disease and Movement Disorders®, showcasing ATH434's potential across various neurological conditions. The company appointed Abby Macnish Niven as CFO and reported a cash balance of A$9.28m as of September 30, 2024, with quarterly operating cash outflows of A$3.31M.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE), a biotechnology company focused on neurodegenerative disease treatments, announced that CEO David Stamler, M.D. will participate in a fireside chat at the 2024 Maxim Healthcare Virtual Summit on October 17, 2024, at 1:30 p.m. ET (October 18, 2024, at 4:30 a.m. AEDT).
The event will be accessible via a live and archived webcast on Alterity's website under the Investors section: Events and Presentations. The webcast archive will be available for three months.
Alterity Therapeutics (NASDAQ: ATHE) presented new data on ATH434 at the Society for Neuroscience 2024 in Chicago. The poster, titled 'Potent Antioxidant and Mitochondrial-protectant Effects of ATH434, a Novel Inhibitor of α-Synuclein Aggregation with Moderate Iron-binding Affinity,' showcased ATH434's neuroprotective and mitochondrial protectant properties, including reducing lipid damage in two neuronal injury models.
The study, led by Dr. Daniel J. Kosman at SUNY Buffalo, demonstrated ATH434's intrinsic antioxidant activity and its ability to redistribute excess labile iron. These properties suggest potential for treating neurodegenerative diseases like Parkinson's. ATH434 also promoted energy production in mitochondria through a pathway less prone to causing oxidative stress in unstressed cells.
Dr. David Stamler, CEO of Alterity, emphasized the importance of these findings in understanding ATH434's potential as a disease-modifying treatment for neurodegenerative disorders.
Alterity Therapeutics (NASDAQ: ATHE) presented multiple data sets at the International Congress of Parkinson's Disease and Movement Disorders®, highlighting the potential of ATH434 as a disease-modifying therapy for Multiple System Atrophy (MSA). Key findings include:
1. In the ATH434-202 Phase 2 open-label trial, 30% of participants showed stable or improved clinical outcomes.
2. Clinical responders demonstrated stability in brain iron levels and neurofilament light chain (NfL) levels, suggesting potential to slow neurodegeneration.
3. ATH434 exhibited a favorable safety profile with no drug-related serious adverse events.
4. The ATH434-201 randomized, double-blind Phase 2 trial baseline data was presented, focusing on early-stage MSA patients.
5. Preclinical data in Parkinson's disease models showed ATH434 reduced brain iron levels and improved motor performance.
Topline data from ATH434-201 is expected in January 2025, with 12-month data from ATH434-202 later in the year.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE), a biotechnology company focused on developing treatments for neurodegenerative diseases, has appointed Abby Macnish Niven as its new Chief Financial Officer (CFO), effective immediately. CEO David Stamler expressed confidence in Ms Macnish Niven's broad experience and financial background to help advance the company's programs.
Ms Macnish Niven brings extensive experience in private wealth management from groups including ANZ, UBS, and Ord Minett. She also consults for various listed and unlisted companies in governance, finance, and corporate structure. She holds Bachelor of Commerce and Bachelor of Science degrees from the University of Western Australia and is a Chartered Finance Analyst.
Ms Macnish Niven replaces Mr Phillip Hains, who served as CFO since December 2023. Mr Hains will continue as Company Secretary.
Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) announced multiple presentations at the International Congress of Parkinson's Disease and Movement Disorders® (MDS) from September 27 to October 1, 2024, in Philadelphia. Highlights include:
1. A late-breaking oral presentation and poster on interim data from the ATH434-202 trial in advanced multiple system atrophy (MSA).
2. An oral presentation and poster on ATH434-201 Phase 2 baseline characteristics.
3. Two additional poster presentations on:
- Association between clinical progression in MSA and brain volume changes
- Effects of ATH434 in a Parkinson's disease model in macaques
These presentations showcase Alterity's progress in developing treatments for neurodegenerative diseases, particularly focusing on their ATH434 compound for MSA and Parkinson's disease.
Alterity Therapeutics (NASDAQ: ATHE) released its Q4 FY24 Quarterly Cash Flow Report, highlighting positive interim data from the ATH434-202 Phase 2 clinical trial for Multiple System Atrophy (MSA). The trial showed improvement in daily living activities and stable or improved neurological symptoms in some patients. The bioMUSE Natural History Study continues to inform Alterity's Phase 2 trials, characterizing early-stage MSA.
Key points:
- Cash balance of A$12.6M as of June 30, 2024
- Positive interim data from ATH434-202 Phase 2 trial
- Ongoing ATH434-201 Phase 2 trial for early-stage MSA
- Presentations at World Orphan Drug Congress and American Academy of Neurology Annual Meeting
- Promising results from bioMUSE study guiding patient selection and endpoints for Phase 2 trials
Alterity Therapeutics (NASDAQ: ATHE), a biotechnology company focused on developing treatments for neurodegenerative diseases, has announced an upcoming investor webinar. The event, hosted by MST Financial, is scheduled for July 25, 2024, at 8:30 AM AEST (July 24, 2024, at 6:30 PM ET).
CEO David Stamler will present recent company developments, including interim data from the Phase 2 open-label study of ATH-434 (202). Investors and shareholders can register for the Zoom webcast and will have the opportunity to ask questions following the presentation.
This webinar provides a platform for Alterity to share its progress in developing disease-modifying treatments and engage with its investor community.
Alterity Therapeutics (NASDAQ: ATHE) has reported positive interim data from its ATH434-202 Phase 2 clinical trial for multiple system atrophy (MSA). Key findings include:
- 43% of participants showed improvement in daily living activities
- 29% had stable or improved neurological symptoms
- Objective biomarkers demonstrated improvement consistent with clinical findings
- ATH434 was well-tolerated with no safety signals detected
The interim analysis included data from 7 participants treated for 6 months and neuroimaging data from 3 participants treated for 12 months. Clinical responders showed reduced iron accumulation in key brain areas and stable levels of NFL, a marker of axonal injury. These results suggest ATH434's potential to modify the course of MSA, particularly in less advanced cases.