Welcome to our dedicated page for Bicycle Therapeutics news (Ticker: BCYC), a resource for investors and traders seeking the latest updates and insights on Bicycle Therapeutics stock.
Bicycle Therapeutics plc (NASDAQ: BCYC) is a clinical-stage pharmaceutical company developing Bicycle molecules, Bicycle Drug Conjugates (BDC) and Bicycle Radioconjugates (BRC) for oncology indications. News about BCYC often centers on progress across its clinical pipeline, strategic collaborations, and financial updates that shape the company’s development plans.
Investors and observers following BCYC news can expect regular updates on clinical trials such as the Duravelo-1 Phase 1 study, the Duravelo-2 Phase 2/3 pivotal trial in metastatic urothelial cancer, and the Duravelo-3 and Duravelo-4 Phase 1/2 studies in Nectin-4–amplified breast cancer and non-small cell lung cancer. The company also reports on data presentations at major scientific meetings, including imaging and clinical data for BRC molecules targeting EphA2 and MT1-MMP.
Company news also covers strategic partnerships, including long-term arrangements with the UK Nuclear Decommissioning Authority, the United Kingdom National Nuclear Laboratory, and SpectronRx to support an end-to-end 212Pb radiopharmaceutical supply chain. Additional announcements highlight Board of Directors changes, formation and expansion of the Research and Innovation Advisory Board, and inducement grants to new employees under the 2024 Inducement Plan.
On this BCYC news page, readers can track press releases on quarterly financial results, regulatory interactions related to zelenectide pevedotin’s potential approval pathway, and anticipated milestones such as dose selection decisions and data disclosures. For those researching Bicycle Therapeutics stock, this news feed provides a centralized view of the company’s operational, clinical, and corporate developments over time.
Bicycle Therapeutics (NASDAQ: BCYC) reported Q3 2024 financial results and business updates. Key highlights include a 45% overall response rate for both zelenectide pevedotin and BT5528 in metastatic urothelial cancer trials. The company's cash position stands at $890.9 million as of September 30, 2024, with runway extending into 2H 2027. Q3 showed a net loss of $50.8 million, or $(0.74) per share. R&D expenses increased to $48.3 million, up from $39.9 million in Q3 2023, while G&A expenses rose to $18.3 million from $16.3 million year-over-year.
Bicycle Therapeutics (NASDAQ: BCYC) presented the first human imaging data at EANM 2024 Congress, validating MT1-MMP as a novel cancer treatment target. The data came from a case study of a 65-year-old male with pulmonary adenocarcinoma, where the Bicycle Radionuclide Conjugates (BRC®) demonstrated positive imaging properties and specific tumor uptake. The company also presented preclinical data showing optimized biodistribution of BRCs with high tumor uptake and reduced kidney retention.
The company announced EphA2 as its second BRC target and plans to collaborate with Eckert & Ziegler for radioisotope supply and BRC development.
Bicycle Therapeutics (NASDAQ: BCYC) will present data on its Bicycle Radionuclide Conjugates (BRC®) at the European Association of Nuclear Medicine (EANM) 2024 Congress in Hamburg, Germany, from October 19-23. The German Cancer Consortium (DKTK) will reveal the first human imaging data for a BRC targeting MT1-MMP, a tumor antigen common in many cancers, on October 22. Additionally, Bicycle Therapeutics will share an e-poster on BRCs for radioisotope delivery to solid tumors. A conference call and webcast will be held on October 23 at 8 a.m. ET to discuss the data and the company's radiopharmaceutical strategy. The call can be accessed by dialing +1-833-816-1408 (U.S.) or +1-412-317-0501 (international) and requesting the Bicycle Therapeutics call. A live webcast and replay will be available on the company's website.
Bicycle Therapeutics (NASDAQ: BCYC) has announced the granting of inducement awards to eight new employees on October 1, 2024. These awards consist of non-qualified share options to purchase a total of 47,600 ordinary shares. The options were granted under the company's 2024 Inducement Plan and approved by the Compensation Committee in accordance with Nasdaq Listing Rule 5635(c)(4).
Each option has an exercise price of $22.63 per share, which was Bicycle Therapeutics' closing trading price on September 30, 2024. The options will vest over four years, with 25% vesting on the one-year anniversary of the vesting commencement date and the remaining 75% vesting monthly over the following 36 months, subject to continued employment.
Bicycle Therapeutics (NASDAQ: BCYC) presented updated clinical results for its oncology pipeline at ESMO Congress 2024. Key highlights include:
1. Zelenectide pevedotin (Nectin-4 targeting) showed a 45% overall response rate (ORR) in metastatic urothelial cancer (mUC) with 11.1 months median duration of response.
2. BT5528 (EphA2-targeting) demonstrated a 45% ORR in mUC at 6.5 mg/m2 every two weeks.
3. Both drugs showed low frequency and severity of treatment-related peripheral neuropathy.
4. BT7480 (Nectin-4 targeted CD137 agonist) showed a favorable safety profile and preliminary antitumor activity in advanced solid tumors.
These results support the potential of Bicycle's technology platform to create differentiated medicines for cancer treatment.
Bicycle Therapeutics plc (NASDAQ: BCYC) has announced the granting of inducement awards to seven new employees on September 3, 2024. These awards consist of non-qualified share options to purchase a total of 29,500 ordinary shares. The options were granted under Bicycle Therapeutics' 2024 Inducement Plan and approved by the Compensation Committee in accordance with Nasdaq Listing Rule 5635(c)(4).
Key details of the options include:
- Exercise price: $21.50 per share (based on the closing trading price on August 30, 2024)
- Vesting period: 4 years (25% after one year, remaining balance monthly over 36 months)
- Subject to continued employment with the company
These awards are designed to serve as an inducement for new employees joining Bicycle Therapeutics.
Bicycle Therapeutics (NASDAQ: BCYC), a pharmaceutical company developing innovative therapeutics using its proprietary bicyclic peptide (Bicycle®) technology, has announced its participation in two upcoming investor conferences in September 2024:
1. Morgan Stanley 22nd Annual Global Healthcare Conference on September 4, with a fireside chat at 8:30 a.m. ET
2. 2024 Cantor Global Healthcare Conference on September 18, with a fireside chat at 11:30 a.m. ET
Live webcasts of both fireside chats will be available on the company's website in the Investor section, with archived replays accessible after the events. This participation provides an opportunity for investors to gain insights into Bicycle Therapeutics' progress and future plans.
Bicycle Therapeutics (NASDAQ: BCYC) reported progress and financial results for Q2 2024. Key highlights include:
1. Four abstracts accepted for poster presentation at ESMO Congress 2024
2. Focused R&D pipeline on high-potential clinical programs
3. Streamlined leadership team and formed Clinical Advisory Board
4. Raised $555 million in PIPE financing
5. Cash and cash equivalents of $961.4 million as of June 30, 2024
6. R&D expenses of $40.1 million for Q2 2024
7. Net loss of $39.8 million, or $(0.77) per share for Q2 2024
The company expects its current cash position to provide financial runway into 2H 2027.
Bicycle Therapeutics plc (NASDAQ: BCYC) has announced the granting of inducement awards to seven new employees on August 1, 2024. These awards consist of non-qualified share options to purchase a total of 71,200 ordinary shares. The options were granted under the company's 2024 Inducement Plan and approved by the Compensation Committee in accordance with Nasdaq Listing Rule 5635(c)(4).
The options have an exercise price of $24.31 per share, which was Bicycle Therapeutics' closing trading price on July 31, 2024. The vesting schedule spans four years, with 25% vesting on the one-year anniversary of the vesting commencement date and the remaining 75% vesting monthly over the subsequent 36 months. The vesting is subject to the employees' continued service with the company.
Bicycle Therapeutics (NASDAQ: BCYC) announced the acceptance of four abstracts for poster presentation at the ESMO Congress 2024 in Barcelona. The presentations will cover:
1. Updated results of BT8009 monotherapy in metastatic urothelial carcinoma patients
2. Peripheral neuropathy following treatment with BT8009 or BT5528 in advanced solid tumors
3. Phase 1/2 study of BT5528 in patients with advanced solid tumors
4. Initial results from a phase 1/2 study of BT7480 in patients with advanced solid tumors
These presentations highlight Bicycle's progress in developing its proprietary bicyclic peptide (Bicycle®) technology for various cancer treatments. The posters will be available on the company's website after the presentations.
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