Bioxytran Tests Acellular Oxygen Carrier BXT-25 in Pre-Clinical Trials

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BOSTON, MASSACHUSETTS, April 19, 2023 (GLOBE NEWSWIRE) -- BIOXYTRAN, INC. (BIXT), (the “Company”), a clinical stage biotechnology company developing oral drugs to treat COVID-19 and other viral diseases, announced that its long awaited Acelluar Oxygen Carrier BXT-25 has been successfully tested in animals. The initial results are very encouraging because they show the non-toxicity of the experimental drug, along with the corresponding full recovery in Swiss Albino mice, in an experiment carried out in a joint venture with NDPD Pharma, Inc. As a next step, the Company intends to proceed with a 14-day repeated dose toxicity study using New Zealand Rabbits and Wistar Rats as funding permits.

The animal protocol used on the Swiss Albino mice hemorrhaged 20% of the animal’s blood which normally increases heart and respiratory rates. The fact that none of the treated animals experienced any symptoms is a huge testament to the potential efficacy of the experimental oxygen transport molecule. Reading into the data a little more, revealed that the mice fully recovered because their bodies were able to replenish the lost blood as BXT-25 was metabolized by the animal.

This breakthrough opens up the possibility of creating one of the largest platform drugs in existence. Since BXT-25 is 5,000 times smaller than a blood cell, it has the ability to permeate hypoxic regions of the body’s organs where the vasculature doesn’t support good blood flow. Many familiar with Hyperbaric Oxygen Treatment (HBOT) could think of BXT-25 as the intravenous version of HBOT treatment that lasts 9-18 hours and without any harmful side effects. HBOT treatment typically lasts no more than 1.25 hours daily, due to the risks of side effects. The platform drug was designed to be non-toxic and target both hypoxia and degenerative diseases. The company expects BXT-25 will represent a new paradigm in the way strokes and neurodegenerative diseases such as Alzheimer’s, Dementia, and Traumatic Brain Injury are treated. Other indications like ARDS, Sickle Cell Anemia, and Wound healing are some diverse indications that could benefit from BXT-25. The company also has an exclusive license to use the MDX viewer in clinical trials. The MDX viewer is FDA Approved, with a 510-K label to measure the level of hypoxia in cells.

About BXT-25

BXT-25, will be tested as a potent resuscitative agent to treat cerebrovascular accidents. The product is based on a new molecule reversing hypoxia in areas have limited access, originally developed for cerebral contrast imaging. The company plans to submit an Investigational New Drug Application to the Food and Drug Administration (FDA) and enter into clinical trials on stroke patients.

Initial non-clinical studies on animals indicated positive results:

  • No nitric oxide scavenging (absence of increased blood pressure)
  • No animal toxicity.
  • Oxygen delivery to hypoxic cells

The Company’s objective is to conduct proof of concept clinical trials for safety and efficacy of BXT-25 and enter into business relations with several large drug companies.

About Bioxytran, Inc.

Bioxytran, Inc. is a clinical stage biotechnology company developing novel therapies targeting the treatment of significant unmet medical needs in virology, degenerative disease, and hypoxia. The leading drug candidate, Prolectin-M, is a new class of antiviral drug designed to antagonize galectins implicated in inflammatory, fibrotic, and malignant diseases. Bioxytran’s other development programs are for pulmonary fibrosis and stroke treatment. More information can be found at

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Michael Sheikh

Forward-Looking Statements

This press release includes forward-looking statements as defined under federal law, including those related to the performance of technology described in this press release. These forward-looking statements are generally identified by the words “believe,” “expect,” “anticipate,” “estimate,” “intend,” “plan,” and similar expressions, although not all forward-looking statements contain these identifying words. Such statements are subject to significant risks, assumptions and uncertainties. Known material factors that could cause Bioxytran’s actual results to differ materially from the results contemplated by such forward-looking statements are described in the forward-looking statements and risk factors in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2021 and those risk factors set forth from time-to-time in other filings with the Securities and Exchange Commission. Bioxytran undertakes no obligation to correct or update any forward-looking statement, whether as a result of new information, future events, or otherwise, except to the extent required under federal securities laws.

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About BIXT

bioxytran, inc., an early stage pharmaceutical company, focuses on the development, manufacture, and commercialization of various therapeutic drugs to address hypoxia in humans. the company's lead pharmaceutical drug candidate is bxt-25, an oxygen-carrying small molecule consisting of bovine hemoglobin stabilized with a co-polymer for the treatment of patients with ischemia of the brain resulting from a stroke or the blockage of the blood vessels to the brain. its products also include bxt-252, an injectable anti-necrosis drug to treat a wound that does not heal because limited amount of oxygen reaching the wound. the company was founded in 2017 and is headquartered in newton, massachusetts.