PhenomeX Launches the Opto® T Cell Profiling Workflow
This workflow revolutionizes immunotherapy research and development by comprehensively profiling single T cells to correlate polyfunctionality with cytotoxicity and recovery of those same cells for downstream analysis
Polyfunctional T cells, which produce multiple cytokines, are considered to be the most potent anti-tumor effector T cells. To find polyfunctional T cells in a heterogeneous sample, scientists must be able to characterize cytokine secretion and cytotoxicity at the single-cell level. However, most existing methods evaluate samples in bulk and are destructive endpoint assays, preventing direct correlation of cytokine secretion with cytotoxicity or multi- omic profiling.
With the PhenomeX Optofluidic Platforms, along with OptoSelect® chips that contain thousands of NanoPen® chambers, single T cells are sorted and isolated in NanoPen chambers using opto-electropositioning (OEP®). After loading, a variety of assays can be performed to profile single T cells. Analysis using intuitive software is then performed to identify cells with phenotypes of interest, and guide recovery of the same cells for downstream assays enabling researchers to gain a deeper understanding of the underlying biology by:
- Investigating genetic drivers associated with polyfunctional T cells;
- Identifying desirable phenomes by correlating polyfunctionality with cytotoxicity; and
- Linking desirable phenotypes to gene sequences of the same cells.
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PhenomeX is empowering scientists to leverage the full potential of each cell and drive the next era of functional cell biology that will advance human health. We enable scientists to reveal the most complete insights on cell function and obtain a full view of the behavior of each cell. Our unique suite of proven high-throughput tools and services offer unparalleled resolution and speed, accelerating the insights that are key to advancing discoveries that can profoundly improve the prevention and treatment of disease. Our award-winning platforms are used by researchers across the globe, including those at the top 15 global pharmaceutical companies and approximately
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