11 Presentations on Day 2 of Bionano Symposium 2026 Showcase Expanding Impact of Optical Genome Mapping Across Oncology and Cell & Gene Therapy
Rhea-AI Summary
Bionano Genomics (Nasdaq: BNGO) reported Day 2 highlights from Symposium 2026 focused on oncology and bioprocessing applications of Optical Genome Mapping (OGM). Presentations showed OGM detecting complex structural variants in multiple myeloma, rare sarcomas, and engineered cell lines, and discussed FDA and ISSCR recognition for genome-integrity analysis.
Attendance exceeded 1,150 registrants from 73 countries; session recordings will be available on Bionano's YouTube channel.
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Key Figures
Market Reality Check
Peers on Argus
BNGO fell 0.88% while peers showed mixed moves: HBIO up 3.75%, RVP up 0.3%, NXGL down 1.67%, FEMY down 0.91%, MHUA down 27.18%. The momentum scanner did not flag a coordinated sector move, suggesting this symposium news was largely stock-specific.
Historical Context
| Date | Event | Sentiment | Move | Catalyst |
|---|---|---|---|---|
| Feb 24 | Symposium day 1 recap | Positive | -0.9% | Day 1 OGM symposium highlights in hematologic malignancies and applications. |
| Feb 09 | Symposium announcement | Positive | +0.0% | Announcement of free virtual Bionano Symposium 2026 with >30 researchers. |
| Feb 04 | Gene editing publication | Positive | -1.3% | Peer-reviewed study showing OGM detects gene-editing-induced genomic alterations. |
| Jan 12 | Prelim 2025 results | Negative | +0.6% | Preliminary Q4 and FY2025 revenue declines with flowcell and system metrics. |
| Dec 11 | AMP 2025 recap | Positive | -1.2% | AMP meeting recap of 13 OGM studies across multiple disease areas. |
Recent history shows frequent negative price reactions around generally positive OGM and conference news, with only the preliminary 2025 results posting a small gain.
Over the last few months, Bionano has repeatedly highlighted advances and adoption of optical genome mapping (OGM), including AMP 2025 data on structural variant detection, a February 2026 publication on detecting gene editing alterations, and multi-day Bionano Symposium 2026 programming. Despite these technically positive updates, shares often moved lower afterward, while preliminary Q4 and FY2025 results with year-over-year revenue declines saw a modest 0.63% gain. Today’s Day 2 symposium oncology and bioprocessing focus continues this theme of expanding OGM use across hematologic malignancies, solid tumors, and cell and gene therapy quality control.
Market Pulse Summary
This announcement underscores growing adoption of optical genome mapping across hematologic malignancies, solid tumors, and cell and gene therapy quality control, with 11 Day 2 presentations and more than 1,150 global participants from 73 countries. It follows prior conference recaps and publications highlighting OGM’s sensitivity and breadth. Investors may track how this expanding research footprint translates into system placements, consumable usage, and revenue trends, particularly given the company’s recent preliminary 2025 results and its position well below the 52-week high.
Key Terms
optical genome mapping medical
structural variants medical
karyotyping medical
immunotherapy medical
homologous recombination deficiency (HRD) medical
gene editing medical
AI-generated analysis. Not financial advice.
SAN DIEGO, Feb. 25, 2026 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (Nasdaq: BNGO) today announced highlights from Day 2 of Bionano Symposium 2026, which focused on New Frontiers in Oncology and Bioprocessing Applications with Optical Genome Mapping (OGM). The session revealed how OGM can offer a new standard for detecting and characterizing structural variants (SVs) across cancer, including its unprecedented resolution in rare and heterogeneous cancers. Presentations also described how OGM is increasingly recognized, including by the US Food and Drug Administration (FDA), for its ability as a leading technique for highly sensitive analysis of genome integrity for development of cell and gene therapies such as stem cell therapy and gene editing in the biotechnology and pharmaceutical industries.
Attendance at Symposium 2026 continues to grow, now with more than 1,150 registered participants from 73 countries across 6 continents, making Symposium 2026 the single largest global event dedicated to OGM and Bionano solutions this year. The call for posters ended on Day 2, but submissions were continuing to roll in and like the oral presentations, they underscore how OGM can enable scientists, clinicians, and industry researchers to uncover complex genomic events often missed by conventional cytogenetics, fluorescence in-situ hybridization (FISH), or sequencing.
11 presenters from leading academic, clinical, and industry centers across Europe and the U.S., including Alka Chaubey, PhD, FACMG, Bionano’s chief medical officer, who opened the day by highlighting OGM’s ability to deliver unbiased, comprehensive, genome-wide structural variant detection across both cancer and engineered cell line applications, providing actionable insights that may drive future research, diagnostics development, and therapeutic innovation.
Among the key scientific highlights:
Dr. Hippolyte Guerineau (Centre Hospitalier de Versailles) presented results from a one-year prospective study implementing OGM in 214 multiple myeloma samples. The study demonstrated high concordance with FISH while revealing additional structural complexity, including chromoanagenesis events and immunotherapy-relevant alterations, underscoring OGM’s ability to expand the genomic landscape accessible to myeloma research.
Dr. Agnes Daudignon (CHU de Lille) introduced the FrOGG (French Speaking OGM Group) consortium, a collaborative network standardizing OGM in onco-hematology across France, Canada, Switzerland, and Belgium. The group has already implemented the first national external quality control program for OGM and is developing a centralized data hub to advance research and adoption.
Dr. Ying Zou (Johns Hopkins University) and Dr. Alejandro Berenguer Rubio (Instituto de Investigación Sanitaria La Fe) presented complementary research in rare sarcomas. Across 201 soft tissue sarcoma samples with normal karyotypes, OGM detected significant structural variants in over
Dr. Marc-Henri Stern (Institut Curie) presented a novel OGM-based assay for detecting homologous recombination deficiency (HRD) in breast and ovarian cancers. Using genome-wide structural variant patterns, the assay achieved high predictive accuracy for HRD status, illustrating OGM’s potential to enhance biomarker-driven precision oncology.
Dr. Adrian Dubuc (Roswell Park Comprehensive Cancer Center) & Dr. Phillip D. Michaels (Brigham and Women’s Hospital and Harvard Medical School) co-presented the 1000X Genome Project, an initiative pushing the boundaries of OGM to deeply characterize the genomic architecture of plasma cell myeloma. Ultra-deep OGM analysis without CD138-enrichment, revealed previously unrecognized complex rearrangements, showcasing the potential of OGM as a framework for high-resolution structural variant profiling in genomically complex cancers.
OGM’s transformative potential in engineered cell lines was demonstrated by Dr. Annelise Bennaceur-Griscelli (CiTHERA - Center for iPS Cell Therapies), James Haldane (bit.bio) & Dr. Darren “Ben” Finlay (Sanford Burnham Prebys Medical Discovery Institute). Together, they showed how OGM can enable genome-wide surveillance of induced pluripotent stem cells (iPSC) and engineered cell lines, uncovering variants introduced during development including off-target modifications, culture-associated variants, reprogramming-related structural changes, and subtle genomic rearrangements that have the potential to influence cell function. Dr Bennaceur-Griscelli also highlighted published guidance by the International Society for Stem Cell Research (ISSCR) and the FDA regarding the use of OGM as a highly sensitive method for detecting structural aberrations not visible by karyotyping.
The session concluded with a live panel discussion and Q&A session with speakers and moderated by Bionano’s Dr. Chaubey, Dr. Andy O’Shaughnessy, Dr. Dana Jaber, and Cami Asher. Panelists discussed fostered collaborations around best practices for OGM implementation, advancing multiple myeloma research, QC strategies, and how emerging research is pushing the boundaries of OGM applications, along with future directions in research and bioprocessing.
“Day 2 of Symposium 2026 demonstrated how OGM is advancing both cancer research and bioprocessing applications by revealing genomic complexity at a scale and resolution that were previously inaccessible,” said Dr. Chaubey. “From challenging hematologic malignancies and rare sarcomas to engineered iPSC lines, OGM’s versatility is driving discovery, standardization, and innovation across diverse scientific domains.”
Erik Holmlin, president and chief executive officer of Bionano, added, “Day 2 brought more in-depth reporting by scientists and clinical researchers on the application of OGM in cancer, with today’s topics expanding into the realm of solid tumors. Use of OGM as an analytical tool in cell and gene therapy development was covered by academic researchers and scientists from industry, who made the case of OGM use for genome integrity quality control (QC) in bioprocessing. These presentations reinforce OGM’s utility and importantly outline a large market opportunity beyond hematologic malignancies, with application in solid tumor research and therapy development.”
Session recordings will be available on-demand via the Bionano YouTube channel. The live panel discussion and Q&A session will not be available on-demand.
Bionano Symposium 2026 continues with Day 3: OGM Making its Mark in Constitutional Genetic Disorders on February 25, 2026, from 7:00-10:00 AM PT. Attendees may also explore scientific posters available throughout the event on the virtual platform.
Don’t miss the Bionano Symposium 2026, register now! Symposium registration is free and open to all. To register, visit: www.bionano.com/symposium-2026
About Bionano Genomics
Bionano is a provider of genome analysis solutions that can enable researchers and clinicians to reveal answers to challenging questions in biology and medicine. The Company’s mission is to transform the way the world sees the genome through optical genome mapping (OGM) solutions, diagnostic services and software. The Company offers OGM solutions for applications across basic, translational and clinical research. The Company also offers an industry-leading, platform-agnostic genome analysis software solution, and nucleic acid extraction and purification solutions using proprietary isotachophoresis (ITP) technology. Through its Lineagen, Inc. d/b/a Bionano Laboratories business, the Company also offers OGM-based diagnostic testing services.
For more information, visit www.bionano.com or www.bionanolaboratories.com.
Bionano’s products are for research use only and not for use in diagnostic procedures.
Forward-Looking Statements of Bionano Genomics
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical facts contained in this press release, including statements regarding our future results of operations or financial condition, business strategy and plans, and objectives of management for future operations, are forward-looking statements. Words such as “ability,” “anticipate,” “believe,” “can,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” or “would” and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) convey uncertainty of future events or outcomes and are intended to identify these forward-looking statements. Forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things; the ability and utility of OGM to offer a new standard for detecting and characterizing SVs across cancers; the ability and utility of OGM being recognized as a leading technique for highly sensitive analysis of genome integrity for development of cell and gene therapies such as stem cell therapy and gene editing in the biotechnology and pharmaceutical industries; the ability and utility of OGM to enable scientists, clinicians, and industry researchers to uncover complex genomic events often missed by conventional cytogenetics, FISH, or sequencing; the ability and utility of OGM to provide actionable insights that drive future research, diagnostics development, and therapeutic innovation; the ability and utility of OGM to provide high concordance with FISH while revealing additional structural complexity, including chromoanagenesis events and immunotherapy-relevant alterations; the ability and utility of OGM to detect significant structural variants and reveal cryptic and complex genomic rearrangements missed by conventional karyotyping; the ability and utility of OGM to uncover hidden genomic complexity in solid tumors and advance high-resolution research insights; the ability and utility of OGM to enhance biomarker-driven precision oncology; the ability and utility of OGM as a framework for high-resolution structural variant profiling in genomically complex cancers; the ability and utility of OGM to enable genome-wide surveillance of iPSCs and engineered cell lines, and uncover variants introduced during development; continued research, presentations and publications involving OGM, its utility compared to traditional cytogenetics and our technologies; our ability to drive adoption of OGM and our technology solutions; and any other statements that are not of historical fact. Each of these forward-looking statements involves risks and uncertainties. Accordingly, investors and prospective investors are cautioned not to place undue reliance on these forward-looking statements as they involve inherent risk and uncertainty (both general and specific) and should note that they are provided as a general guide only and should not be relied on as an indication or guarantee of future performance. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks and uncertainties associated with: the failure of OGM to offer a new standard for detecting and characterizing SVs across cancers; the failure of OGM to be recognized as a leading technique for highly sensitive analysis of genome integrity for development of cell and gene therapies such as stem cell therapy and gene editing in the biotechnology and pharmaceutical industries; the failure of OGM to enable scientists, clinicians, and industry researchers to uncover complex genomic events often missed by conventional cytogenetics, FISH, or sequencing; the failure of OGM to provide actionable insights that drive future research, diagnostics development, and therapeutic innovation; the failure of OGM to provide high concordance with FISH while revealing additional structural complexity, including chromoanagenesis events and immunotherapy-relevant alterations; the failure of OGM to detect significant structural variants and reveal cryptic and complex genomic rearrangements missed by conventional karyotyping; the failure of OGM to uncover hidden genomic complexity in solid tumors and advance high-resolution research insights; the failure of OGM to enhance biomarker-driven precision oncology; the failure of OGM as a framework for high-resolution structural variant profiling in genomically complex cancers; the failure of OGM to enable genome-wide surveillance of iPSCs and engineered cell lines, and uncover variants introduced during development; our ability to obtain sufficient financing to fund our strategic plans and commercialization efforts and our ability to continue as a “going concern,” which requires us to manage costs and obtain significant additional financing to fund our strategic plans and commercialization efforts; the risk that if we fail to obtain additional financing we may seek relief under applicable insolvency laws; the impact of adverse geopolitical and macroeconomic events and uncertain market conditions, including inflation, tariffs, and supply chain disruptions, on our business and the global economy; general market conditions; changes in the competitive landscape and the introduction of competitive technologies or improvements to existing technologies; changes in our strategic and commercial plans; the ability of medical and research institutions to obtain funding to support adoption or continued use of our technologies; study results that differ or contradict the results mentioned in this press release and at Day 2 of Symposium 2026; and the risks and uncertainties associated with our business and financial condition in general, including the risks and uncertainties including those described in our filings with the Securities and Exchange Commission (“SEC”), including, without limitation, our Annual Report on Form 10-K for the year ended December 31, 2024, our Quarterly Reports on Form 10-Q and in other filings subsequently made by us with the SEC. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based on management’s assumptions and estimates as of such date. We do not undertake any obligation to publicly update any forward-looking statements, whether as a result of the receipt of new information, the occurrence of future events or otherwise, except as may be required by law.
CONTACTS
Company Contact:
Erik Holmlin, CEO
Bionano Genomics, Inc.
+1 (858) 888-7610
eholmlin@bionano.com
Investor Relations:
Kelly Gura
Gilmartin Group
+1 (212) 229-6163
IR@bionano.com
FAQ
What did Bionano (BNGO) present about OGM and multiple myeloma on February 25, 2026?
How did OGM perform in rare sarcoma studies presented at Bionano Symposium 2026 (BNGO)?
What evidence did Bionano (BNGO) share about OGM for engineered cell lines and iPSC QC?
Did Bionano (BNGO) report regulatory recognition of OGM at Symposium 2026?
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