Can-Fite BioPharma Ltd. Stock Price, News & Analysis

Can-Fite BioPharma (NYSE American: CANF) reported significant clinical progress with its drug Namodenoson in treating decompensated liver cirrhosis under a compassionate use program. After 20 months of treatment, the patient showed notable improvements, including resolution of moderate ascites, no further gastrointestinal bleeding episodes, and decreased liver stiffness and globulin levels.

Dr. Ohad Etzion from Soroka Medical Center highlighted the drug's potential importance, given the treatment options currently available besides liver transplantation. The liver cirrhosis treatment market is projected to reach approximately $15 billion in the U.S. by 2030, addressing a global patient population of 10.6 million affected by decompensated cirrhosis as of 2017.

Can-Fite BioPharma (NYSE American: CANF) has announced an upcoming investor webinar scheduled for February 25, 2025, at 4:15 p.m. ET. The event will feature presentations from CEO Motti Farbstein and Executive Chairperson/CSO Dr. Pnina Fishman, focusing on the company's development pipeline and upcoming milestones.

The company has secured multiple out-licensing deals with potential regulatory and sales milestone payments exceeding $130 million, of which $20 million has already been received in upfront and milestone payments. Can-Fite's advanced-stage assets target markets valued at over $70 billion, positioning the company for potential commercialization of its therapies targeting oncological and inflammatory diseases.

Can-Fite BioPharma (NYSE American: CANF) has announced its participation in the BIO CEO & Investor Conference 2025, scheduled for February 10-11, 2025, in New York City. The company's Chief Executive & Chief Financial Officer, Motti Farbstein, will present on February 10 at 3:45 pm EST at the New York Marriott Marquis.

During the conference, management will conduct one-on-one meetings with investors and potential partners to discuss business strategy, clinical milestones, and development plans. The company's drug pipeline includes Namodenoson, currently in a pivotal Phase III trial for advanced liver cancer and a Phase IIb study for Metabolic Dysfunction-associated Steatohepatitis (MASH). Additionally, Piclidenoson is preparing to enter a pivotal Phase III trial for psoriasis.

Can-Fite BioPharma (NYSE American: CANF) announced that its lead drug candidate Namodenoson has been granted a US patent for use as an anti-obesity drug. The patent (No. 17/309,952), expiring in 2042, covers methods of treating obese patients with oral Namodenoson.

The drug demonstrated effectiveness by reducing fat levels through increased adiponectin hormone production and showed weight reduction in animal obesity models. In a Phase IIa MASH study, patients treated with Namodenoson experienced a 2.3% weight loss after 3 months with significant adiponectin level increases.

Namodenoson is currently in Phase IIb trials for MASH treatment, where most patients are obese. The global obesity treatment industry is projected to reach $60.5 billion by 2030, with an expected compound annual growth rate of 22.3% from 2025-2030.

Can-Fite BioPharma (NYSE American: CANF) announced that its research on Namodenoson's liver protective effects will be presented at the 2025 ASCO Gastrointestinal Cancers Symposium. The company is currently conducting a pivotal Phase 3 multinational registrational trial for advanced liver cancer treatment. Notably, Namodenoson has shown remarkable results in one HCC patient who has remained cancer-free for over 8 years through a compassionate use program. The drug demonstrates dual benefits: anti-cancer activity and liver-protective effects, including anti-steatosis, anti-inflammatory, anti-fibrotic, and anti-ischemic properties. The protective mechanism works through adiponectin protein, which provides liver-, cardio-, and neuro-protective effects.

Can-Fite BioPharma (NYSE American: CANF) reported remarkable results from their compassionate use program, where a patient with advanced liver cancer treated with Namodenoson has achieved an 8-year survival with complete response. The patient experienced disappearance of ascites, normal liver function, and good quality of life.

The company is currently enrolling patients in Israel, Europe, and the US for a pivotal Phase III clinical study for advanced HCC as a 2nd or 3rd line treatment. Namodenoson, administered orally twice daily, has received Orphan Drug status from both FDA and EMA, along with FDA Fast Track Status for HCC treatment.

The liver cancer treatment market is projected to reach $6.1 billion by 2027 in G8 countries, with liver cancer causing over 700,000 deaths globally each year.

60 Degrees Pharmaceuticals (SXTP) and Can-Fite BioPharma (CANF) will be featured on the RedChip Small Stocks, Big Money show on Bloomberg TV on November 23 at 7 p.m. ET. The program, reaching approximately 73 million U.S. homes, will include interviews with both companies' CEOs. Geoffrey Dow from SXTP will discuss their FDA-approved antimalarial drug ARAKODA and plans to expand its use for diseases like babesiosis. Motti Farbstein from Can-Fite will present their oral drug platform targeting oncology and inflammatory diseases, along with updates on their late-stage clinical pipeline.

Can-Fite BioPharma (NYSE American: CANF) has announced the first patient dosing in its Phase IIa clinical trial for advanced pancreatic adenocarcinoma. The multicenter open-label trial will evaluate Namodenoson, administered orally at 25 mg twice daily, in approximately 20 evaluable patients whose disease has progressed on at least first-line therapy. The study's primary objective is to assess safety, while secondary objectives include evaluating clinical activity through metrics like Objective Response Rate, Progression-Free Survival, and Overall Survival. The trial is being conducted at Rabin Medical Center, Israel, and UT Southwestern Medical Center, US. Notably, Namodenoson has recently received Orphan Drug Designation from the US FDA.

Can-Fite BioPharma (NYSE American: CANF) has received patent allowance in Australia for its drug Namodenoson for anti-obesity treatment, valid until 2040. The patent covers methods of treating obese patients using oral Namodenoson, which has shown promising results in reducing fat levels by increasing adiponectin hormone. In a Phase IIa study for MASH patients, the drug demonstrated a 2.3% weight loss after 3 months with significant increases in adiponectin levels. The drug is currently in Phase IIb trials for MASH treatment, where most patients are obese. The global obesity treatment market was valued at USD 12 billion in 2023, with Australia alone expecting approximately 1.85 Million MASH patients.