Conduit Pharmaceuticals Selects Initial Indications for Lead Clinical Candidate Targeting Autoimmune Disorders

Rhea-AI Summary

Conduit Pharmaceuticals (Nasdaq: CDT) has announced plans to initiate Phase 2a clinical trials for its lead candidate, AZD1656, targeting systemic lupus erythematosus and ANCA-associated vasculitis. AZD1656, a HK-4 glucokinase activator originally developed by AstraZeneca for diabetes, is being repurposed for autoimmune disorders. The drug has an established safety profile, tested in over 1,000 patients across 20+ trials. Conduit aims to leverage AZD1656's potential as a first-in-class therapy for autoimmune diseases, addressing the unmet medical needs in lupus treatment, which affects over 5 million people worldwide. The global lupus treatment market is expected to grow from $2.7 billion in 2024 to $4.9 billion by 2030, with a CAGR of 8.9%.

Positive

• Initiation of Phase 2a clinical trials for AZD1656 in systemic lupus erythematosus and ANCA-associated vasculitis
• AZD1656 has an established safety profile, tested in over 1,000 patients across 20+ trials
• Potential to become a first-in-class therapy for autoimmune diseases
• Targeting a growing market: lupus treatment market expected to reach $4.9 billion by 2030 (CAGR 8.9%)
• Addressing unmet medical needs in lupus treatment, which affects over 5 million people worldwide

Negative

• None.

Insights

Medical Research Analyst

Conduit Pharmaceuticals' decision to repurpose AZD1656 for autoimmune disorders is a strategic move with significant potential. The choice of systemic lupus erythematosus (SLE) and ANCA-associated vasculitis as initial indications is particularly noteworthy. These conditions represent areas of high unmet medical need, with current treatments often relying on broad immunosuppression with substantial side effects.

The extensive safety data from over 1,000 patients in 20+ trials provides a solid foundation for AZD1656's development in autoimmune diseases. This could potentially accelerate the drug's path to market. The mechanism of action, as a HK-4 glucokinase activator, offers a novel approach to modulating the immune system, which could provide a more targeted treatment option compared to current therapies.

With a projected market size of $4.9 billion for lupus treatments by 2030 and a $620 million market for ANCA-associated vasculitis in the U.S. alone, Conduit is targeting lucrative markets with significant growth potential. If successful, AZD1656 could capture a substantial market share and potentially become a first-in-class therapy for these autoimmune conditions.

Financial Analyst

Conduit Pharmaceuticals' strategy to repurpose AZD1656 for autoimmune disorders is a savvy move that could significantly boost the company's value proposition. By targeting systemic lupus erythematosus and ANCA-associated vasculitis, Conduit is entering markets with substantial growth potential and high unmet needs.

The global lupus treatment market, projected to reach $4.9 billion by 2030 with a 8.9% CAGR, presents a lucrative opportunity. Additionally, the $620 million U.S. market for ANCA-associated vasculitis treatments further expands Conduit's potential revenue streams.

Investors should note that repurposing an existing drug with an established safety profile could lead to faster and more cost-effective development compared to creating a new compound from scratch. This approach could potentially accelerate time-to-market and reduce R&D expenses, improving the company's risk-reward profile. However, it's important to monitor the upcoming Phase 2a trial results, as they will be pivotal in determining AZD1656's efficacy in these new indications and, consequently, Conduit's future market position.

• Conduit Pharmaceuticals announces plans to initiate Phase 2a trials in both systemic lupus erythematosus and ANCA-associated vasculitis for its lead clinical candidate, AZD1656
• AZD1656, a HK-4 glucokinase activator initially developed by AstraZeneca for diabetes, is now being repurposed by Conduit for autoimmune disorders, leveraging its established safety profile and targeted immune-modulating effects
  

SAN DIEGO and LONDON, Aug. 12, 2024 (GLOBE NEWSWIRE) -- Conduit Pharmaceuticals Inc. (Nasdaq: CDT) (“Conduit” or the “Company”), today announced the selection of initial indications for its lead clinical candidate, HK-4 glucokinase activator AZD1656 licensed from AstraZeneca on August 7, 2024.

Conduit intends to initiate Phase 2a clinical trials to evaluate AZD1656 for the treatment of systemic lupus erythematosus (including lupus nephritis) and ANCA-associated vasculitis. This represents a significant milestone in the development of AZD1656, underscoring Conduit’s commitment to address unmet medical needs and its confidence in the asset's potential to impact patient outcomes positively.

Carrying out Phase 2a, double-blind, placebo-controlled trials in patients suffering from systemic lupus erythematosus, inclusive of lupus nephritis patients, and patients suffering from ANCA-associated vasculitis, will enable Conduit to assess the potential of AZD1656 across the full spectrum of lupus patients. Simultaneously, we will evaluate the potential of AZD1656 across the broader aspects of autoimmune disorders.

Originally developed by AstraZeneca through Phase 2b for diabetes mellitus, AZD1656 is a highly specific glucokinase activator that has undergone extensive safety testing, involving over 1,000 patients, in more than 20 trials. Conduit envisions AZD1656 as a potential cornerstone asset in the autoimmune sector, leveraging its established safety profile and targeted mechanism of action to activate the patient’s immune system and mitigate harmful inflammation.

“Having reviewed the extensive data, we are delighted to advance AZD1656 into a new therapeutic area targeting systemic lupus erythematosus and ANCA-associated vasculitis,” said Dr. Freda Lewis-Hall, Chair of the Board of Directors at Conduit. “With its potential to become a first-in-class therapy for autoimmune diseases, AZD1656 represents a significant leap forward in our mission to develop ground-breaking treatments that could transform the landscape of autoimmune care and provide innovative treatments that can truly make a difference to patients.”

Lupus affects over 5 million people worldwide, including 1.5 million Americans¹. Yet, despite significant progress in the clinical understanding of the disease, treatment still relies heavily on the use of corticosteroids and non-specific immunosuppressants, widely known for their potentially severe side effects with long term use. Given the wide-ranging clinical manifestations of lupus there is a clear unmet need for safer treatments applicable to all patients.

The global market size for lupus treatments, including systemic lupus erythematosus (SLE) and other lupus-related conditions, was estimated to be around $2.7 billion in 2024. This market is expected to grow significantly, reaching approximately $4.9 billion by 2030 with a compound annual growth rate (CAGR) of approximately 8.9%². In addition, the market size of ANCA-associated vasculitis was highest in the U.S. among the seven major markets in 2023, accounting for approximately $620 million, and is expected to experience significant growth by 2032³.

About Conduit Pharmaceuticals

Conduit is a multi-asset, clinical stage, disease-agnostic life science company delivering an efficient model for compound development. Conduit both acquires and funds the development of Phase 2-ready assets and then seeks an exit through third-party license deals following successful clinical trials. Led by a highly experienced team of pharmaceutical executives including Dr. David Tapolczay and Dr. Freda Lewis-Hall, this novel approach is a departure from the traditional pharma/biotech business model of taking assets through regulatory approval.

Forward-Looking Statements

This press release contains certain forward-looking statements within the meaning of the federal securities laws. All statements other than statements of historical facts contained in this press release, including statements regarding Conduit's future results of operations and financial position, Conduit's business strategy, prospective product candidates, product approvals, research and development costs, timing and likelihood of success, plans and objectives of management for future operations, future results of current and anticipated studies and business endeavors with third parties, and future results of current and anticipated product candidates, are forward-looking statements. These forward-looking statements generally are identified by the words "believe," "project," "expect," "anticipate," "estimate," "intend," "strategy," "future," "opportunity," "plan," "may," "should," "will," "would," "will be," "will continue," "will likely result," and similar expressions. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including, but not limited to; the inability to maintain the listing of Conduit's securities on Nasdaq; the ability to recognize the anticipated benefits of the business combination completed in September 2023, which may be affected by, among other things, competition; the ability of the combined company to grow and manage growth economically and hire and retain key employees; the risks that Conduit's product candidates in development fail clinical trials or are not approved by the U.S. Food and Drug Administration or other applicable authorities on a timely basis or at all; changes in applicable laws or regulations; the possibility that Conduit may be adversely affected by other economic, business, and/or competitive factors; and other risks as identified in filings made by Conduit with the U.S. Securities and Exchange Commission. Moreover, Conduit operates in a very competitive and rapidly changing environment. Because forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified and some of which are beyond Conduit's control, you should not rely on these forward-looking statements as predictions of future events. Forward-looking statements speak only as of the date they are made. Readers are cautioned not to put undue reliance on forward-looking statements, and except as required by law, Conduit assumes no obligation and does not intend to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise. Conduit gives no assurance that it will achieve its expectations.

Media
Sean Leous
ICR Westwicke
Sean.Leous@westwicke.com
+1.646.866.4012

Investors
Bill Begien
Conduit Pharmaceuticals Inc.
bb@conduitpharma.com

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¹ https://www.pfizer.com/disease-and-conditions/lupus#:~:text=Lupus%20is%20a%20global%20disease,in%20the%20United%20States%20alone.&text=Its%20prevalence%20varies%20significantly%20between%20regions.
² https://www.marketresearchfuture.com/reports/systemic-lupus-erythematosus-treatment-market-8500
³ https://finance.yahoo.com/news/anca-associated-vasculitis-industry-epidemiology-084800557.html?guccounter=1&guce_referrer=aHR0cHM6Ly93d3cuZ29vZ2xlLmNvbS8&guce_referrer_sig=AQAAANkxj8q0WJx_FXr2sjJIlSmylTMmxaJeUARmiWNMn6zifDwMsjRLRxrwchkkTJpnSgmOepq9_4F4VcuFTnK9614lev4EU5ZewxV0sp-_HWjYRNJpQXDsL5LmvJKBUGk93MU9si4jNJXm1dHmn9v7YN7MTrQFHB0yTldyLyE3iDHJ

FAQ

What indications has Conduit Pharmaceuticals (CDT) selected for AZD1656?

Conduit Pharmaceuticals (CDT) has selected systemic lupus erythematosus (including lupus nephritis) and ANCA-associated vasculitis as initial indications for AZD1656, planning to initiate Phase 2a clinical trials for these conditions.

What is the original purpose of AZD1656 and how is Conduit Pharmaceuticals (CDT) repurposing it?

AZD1656 was originally developed by AstraZeneca for diabetes. Conduit Pharmaceuticals (CDT) is repurposing it for autoimmune disorders, leveraging its established safety profile and targeted immune-modulating effects.

What is the market potential for lupus treatments according to Conduit Pharmaceuticals' (CDT) press release?

According to the press release, the global market for lupus treatments is estimated to be around $2.7 billion in 2024 and is expected to grow to approximately $4.9 billion by 2030, with a compound annual growth rate (CAGR) of about 8.9%.

How many patients has AZD1656 been tested on, according to Conduit Pharmaceuticals (CDT)?

According to Conduit Pharmaceuticals (CDT), AZD1656 has undergone extensive safety testing, involving over 1,000 patients in more than 20 trials.