Welcome to our dedicated page for Compugen news (Ticker: CGEN), a resource for investors and traders seeking the latest updates and insights on Compugen stock.
Compugen Ltd (CGEN) is a clinical-stage cancer immunotherapy company that regularly issues news on its drug discovery platform, clinical programs, and strategic collaborations. The company emphasizes its predictive AI/ML-powered computational discovery platform, Unigen™, which it uses to identify novel drug targets and biological pathways for immuno-oncology therapies.
News about Compugen often highlights progress across its key clinical-stage assets. Updates include data and trial milestones for COM701, a potential first-in-class anti-PVRIG Fc-reduced antibody, and COM902, a potential best-in-class Fc-reduced high-affinity anti-TIGIT antibody in Phase 1 development. The company also reports on GS-0321 (previously COM503), a potential first-in-class, high-affinity anti-IL-18 binding protein antibody licensed to Gilead, and on rilvegostomig, a PD-1/TIGIT bispecific antibody in Phase 3 development by AstraZeneca under license from Compugen.
Investors following CGEN news can expect coverage of clinical trial initiations and updates, such as the MAIA-ovarian platform trial evaluating COM701 maintenance therapy in relapsed platinum-sensitive ovarian cancer, pooled analyses of Phase 1 trials in platinum-resistant ovarian cancer, and first-in-human studies of GS-0321 in advanced solid malignancies. Company communications also describe partner-led studies of rilvegostomig in indications including non-small cell lung cancer and bladder cancer.
In addition, Compugen’s news flow includes quarterly financial results, cash runway commentary, amendments to collaboration agreements such as royalty monetization transactions with AstraZeneca, and participation in scientific and investor conferences. The CGEN news page on Stock Titan aggregates these announcements so readers can track clinical, financial, and partnership developments from a single source.
Compugen (CGEN) announced new research indicating that targeting PVRIG and TIGIT may improve treatment options for multiple myeloma. Conducted with Dr. James Berenson, the study highlights the expression of the PVRIG/TIGIT pathway in the bone marrow of patients. Details will be presented at the AACR annual meeting from April 8-13, 2022, in New Orleans, with the poster presentation scheduled for April 10, 2022, under number 4934. The data suggest combining TIGIT and PVRIG inhibitors could offer new therapeutic pathways for patients.
Compugen Ltd. (Nasdaq: CGEN) announced the appointment of Mathias Hukkelhoven, Ph.D., to its Board of Directors effective March 1, 2022. Dr. Hukkelhoven brings extensive experience in immuno-oncology and regulatory affairs, having previously served at Bristol Myers Squibb. His background includes involvement in breakthrough drug designations and regulatory strategies. This strategic addition aims to bolster Compugen's innovative pipeline targeting cancer treatments. Dr. Jean-Pierre Bizzari will retire from the board on the same date, concluding his tenure at the company.
Compugen Ltd. (Nasdaq: CGEN) reported its fourth quarter and full-year 2021 financial results, highlighting significant progress in cancer immunotherapy. The company emphasized advancements in its DNAM-1 axis research and early anti-tumor signals from its drugs, COM701 and COM902. Key financials included no revenue for Q4 2021, a total of $6 million for the year, and a net loss of approximately $34.2 million. The company expanded its collaboration with Bristol Myers Squibb with a $20 million investment, while cash reserves totaled about $118 million, expected to fund operations into 2024.
Compugen Ltd. (CGEN) will announce its fourth quarter and full year 2021 financial results on February 24, 2022, before U.S. market open. Management will conduct a conference call and webcast at 8:30 AM ET to discuss the results and provide corporate updates. Compugen is focused on cancer immunotherapy, with lead candidate COM701 in Phase 1 studies. The company also has partnered programs with Bayer and AstraZeneca. Interested parties may access the call via phone or webcast, with a replay available post-event.
Compugen Ltd. (NASDAQ: CGEN), a cancer immunotherapy company based in Israel, will present at the 11th Annual SVB Leerink Global Healthcare Conference on February 16, 2022, at 12:00 pm ET. This virtual event will feature a live webcast available on Compugen's Investor Relations website. The company is focused on innovative predictive target discovery and developing therapeutics, including lead candidate COM701, an anti-PVRIG antibody, and COM902 targeting TIGIT. Compugen's shares are traded on Nasdaq and the Tel Aviv Stock Exchange under the ticker CGEN.
Compugen Ltd. (NASDAQ-GM: CGEN) announced the granting of a new patent by the USPTO for its potential first-in-class therapeutic antibody, COM701, which targets PVRIG. This patent, U.S. Patent No. 11,225,523, protects the use of COM701 in combination with any anti-PD-1 and anti-TIGIT antibodies for cancer treatment. The patent is valid until at least August 2037, reinforcing Compugen's unique position in clinical studies. COM701 is currently undergoing Phase 1 trials, focusing on enhancing T cell activation in tumors.
Compugen Ltd. (CGEN) announced preliminary translational data at the TIGIT Therapies Digital Summit, showcasing immune activation in the tumor microenvironment (TME) after treatment with COM701, its anti-PVRIG antibody. Notable findings include increased TME immune activation and TCR clonality in a patient with MSS-CRC and enhanced immune response markers in ovarian cancer patients treated with COM701 and nivolumab. The company aims to explore PVRIG blockade's potential in treating various tumor types that currently resist existing therapies.
Compugen Ltd. (CGEN) reported third-quarter 2021 results, highlighting the presentation of promising Phase 1/2 data for COM701, combined with Opdivo® and BMS-986207, at SITC. The studies indicated a favorable safety profile for the triple combination therapy, facilitating further evaluations in specific tumor types. The company also secured a $20 million equity investment from Bristol Myers Squibb and a $6 million milestone payment from AstraZeneca. Net loss for the quarter decreased to $6.2 million, while cash reserves totaled approximately $102 million, excluding recent financing.
Compugen Ltd. (CGEN) has announced preliminary results from its Phase 1/2 triple combination study of COM701, an anti-PVRIG antibody, with Opdivo and BMS-986207 targeting advanced solid tumors. The study, presented at the SITC 2021, showed no dose limiting toxicity and a favorable safety profile among 13 heavily pretreated patients. Encouraging outcomes include immune activation and stable disease in 3 patients. COM701 at 20 mg/kg is recommended for further study. Future enrollment in expansion cohorts is planned, highlighting the potential for addressing unmet medical needs in cancer therapy.
Compugen Ltd. (Nasdaq: CGEN) announced new translational data supporting the role of PVRIG as a differentiated checkpoint in cancer immunotherapy during the SITC 2021 conference. Preliminary findings indicate that PVRIG may enhance interactions between stem-like memory T cells and dendritic cells, potentially improving T cell proliferation and tumor infiltration compared to other checkpoints like TIGIT and PD-1. The presentation highlighted significant expressions of PVRIG and its ligand PVRL2, suggesting a promising therapeutic avenue for treating solid tumors.