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Cognition Therapeutics, Inc. (NASDAQ: CGTX) is a clinical-stage biopharmaceutical company developing small molecule therapeutics for age-related degenerative disorders of the central nervous system. Its news flow centers on the clinical and regulatory progress of its lead candidate, zervimesine (CT1812), an investigational oral pill in development for Alzheimer’s disease, dementia with Lewy bodies (DLB) and related conditions.
News updates from Cognition Therapeutics frequently cover milestones in its Phase 2 clinical programs. These include results and analyses from the SHINE study in mild-to-moderate Alzheimer’s disease, the SHIMMER study in mild-to-moderate DLB, and the START study in early Alzheimer’s disease. Articles describe safety and tolerability outcomes, changes in cognition and function measured by validated scales, and exploratory findings in behavioral, movement and neuropsychiatric domains.
Investors following CGTX news also see announcements about expanded access programs for zervimesine in DLB, collaborations with organizations such as the Alzheimer’s Clinical Trials Consortium, and substantial grant support from the National Institute on Aging of the National Institutes of Health. Regulatory and scientific updates, such as end-of-Phase 2 discussions with the U.S. Food and Drug Administration, Type C meeting plans, and presentations at major Alzheimer’s disease conferences, are regular features of the company’s news cycle.
In addition, Cognition Therapeutics issues press releases on financing transactions, including registered direct offerings of common stock and at-the-market equity programs, which provide context on how it funds ongoing and planned studies. For readers tracking CGTX, this news page consolidates clinical, regulatory, scientific and capital markets developments related to zervimesine and the company’s broader neurodegenerative disease pipeline.
Cognition Therapeutics (NASDAQ: CGTX) showcased a poster at the ARVO meeting, highlighting that sigma-2 receptor modulators can restore the normal functioning of retinal pigment epithelial (RPE) cells impaired by dry age-related macular degeneration (AMD).
CT1812, Cognition's lead candidate, demonstrated the ability to rescue vital functions of RPE cells in in vitro models. The company plans to initiate a Phase 2 clinical trial with CT1812 in patients with dry AMD in late 2022. Dry AMD affects around 190 million individuals globally, making it a significant health concern.
Cognition Therapeutics (NASDAQ: CGTX) announced its participation in the ARVO 2022 conference, showcasing preclinical results on sigma-2 receptor modulators that protect retinal pigmented epithelium (RPE) cells. Their lead candidate, CT1812, aims to address dry age-related macular degeneration (AMD) and a Phase 2 clinical study is planned. Dry AMD affects approximately 190 million globally, causing significant vision loss. The poster presentation is scheduled for May 3, 2022, highlighting how these modulators can normalize disrupted homeostatic processes in RPE cells.
Cognition Therapeutics, Inc. (Nasdaq: CGTX) announced that its management will participate in a virtual fireside chat at the B. Riley Securities’ Neuro & Ophthalmology Conference on April 27-28, 2022. The discussion will focus on advancements in their clinical programs targeting age-related diseases affecting the central nervous system and retina, particularly their lead candidate, CT1812. A webcast will be available for viewers, outlining the company's ongoing research and development efforts in Alzheimer’s disease and other conditions.
Cognition Therapeutics, Inc. (Nasdaq: CGTX) announced participation in Needham & Company's 21st Annual Virtual Healthcare Conference from April 11-14, 2022. CEO Lisa Ricciardi will provide a corporate update on April 11, 2022, from 3:00 to 3:40 p.m. ET. A live and archived webcast will be available on the company's investor website. The company focuses on developing innovative drugs targeting age-related degenerative diseases affecting the central nervous system and retina, leveraging expertise in sigma-2 receptor mechanisms.
Cognition Therapeutics (NASDAQ: CGTX) reported a solid financial position after raising $52 million through an upsized IPO and securing $169 million in grant funding. The company is advancing its clinical pipeline for Alzheimer’s disease and dementia with Lewy bodies (DLB), with plans for Phase 2 studies in dry AMD and early-stage Alzheimer’s expected to begin in H2 2022. Despite a net loss of $11.7 million in 2021, Cognition's robust cash reserves of $54.7 million are projected to sustain operations through mid-2023.
Cognition Therapeutics, Inc. (Nasdaq: CGTX) plans to announce its fourth quarter and full year financial results for 2021 on March 30, 2022, before market open. Following this release, the company will host a conference call at 8:00 a.m. ET to discuss the results and provide a business update. Participants can join via telephone or an audio webcast accessible on the company’s website. Cognition focuses on developing innovative therapeutics targeting age-related degenerative diseases.
Cognition Therapeutics (CGTX) is showcasing findings from its clinical development program for CT1812, a sigma-2 receptor modulator targeting Alzheimer's disease, at the AD/PD™ 2022 conference in Barcelona from March 15-20, 2022. Results from the Phase 1b SNAP study indicate significant beta amyloid oligomer displacement into cerebrospinal fluid after CT1812 administration, contrasting with placebo results. Additionally, preliminary findings from the Phase 2 SHINE study highlight potential pharmacodynamic biomarkers linked to Alzheimer's treatment. Full SNAP results will be published in a peer-reviewed journal later this year.
Cognition Therapeutics (Nasdaq: CGTX) announces CEO Lisa Ricciardi's participation in two healthcare conferences. The Oppenheimer 32nd Annual Healthcare Conference will take place on March 16, 2022, at 4:00 p.m. ET, with a live webcast available for 90 days. The Sachs Neuroscience Innovation Forum, focusing on Alzheimer's and dementia, is scheduled for March 22, 2022, at 10:00 a.m. ET, also offering live and on-demand access for registered participants. One-on-one meetings with Ricciardi can be scheduled through event representatives.
Cognition Therapeutics (Nasdaq: CGTX) announced that Anthony Caggiano, M.D., Ph.D., will participate in the BIO CEO & Investor Conference on February 15, 2022, discussing neurodegenerative therapeutics. This panel aims to explore innovative partnerships in the field following a significant investment surge in neuroscience in 2020. Dr. Caggiano emphasized the renewed interest in therapies targeting biological pathways in neurological diseases, highlighting their sigma-2 receptor modulators. The event will be webcasted for registered attendees.
Cognition Therapeutics (Nasdaq: CGTX) announced significant achievements for 2021, including an upsized IPO that generated approximately $52 million and $45 million in grants from the National Institute on Aging for clinical studies. The company appointed new leadership for R&D and expanded its clinical pipeline, demonstrating clinical engagement in Alzheimer's and other neurodegenerative diseases. Looking ahead, Cognition aims to advance multiple studies funded by substantial grants and deliver new therapeutics to enhance shareholder value in 2022.