Welcome to our dedicated page for Chemomab Therapeutics news (Ticker: CMMB), a resource for investors and traders seeking the latest updates and insights on Chemomab Therapeutics stock.
Chemomab Therapeutics Ltd. (CMMB) generates news primarily as a clinical-stage biotechnology company developing nebokitug, a monoclonal antibody targeting the soluble protein CCL24 in fibro-inflammatory diseases. Much of the company’s news flow centers on clinical data, regulatory interactions and scientific presentations related to primary sclerosing cholangitis (PSC), a rare and progressive liver disease with no effective medical therapy other than liver transplantation in advanced cases.
Investors and observers following Chemomab news can expect detailed updates on the Phase 2 SPRING trial of nebokitug in PSC, including results from the double-blind, placebo-controlled portion and the open label extension, where patients received nebokitug for up to 48 weeks. Press releases describe safety and tolerability findings, changes in biomarkers such as ELF score, PRO-C3 and liver stiffness measurements, and analyses in subgroups with moderate or advanced fibrosis. These reports often highlight biomarker patterns that are associated with PSC disease progression and transplant-free survival.
Chemomab’s news also covers regulatory milestones, such as outcomes of End-of-Phase 2 meetings with the FDA, alignment on a single Phase 3 registration trial design using a composite of clinically relevant events, and agreements on Chemistry, Manufacturing and Controls (CMC) and nonclinical toxicology requirements. Additional announcements address Orphan Drug and Fast Track designations for nebokitug, as well as the status of an open U.S. IND for systemic sclerosis.
Another recurring theme in Chemomab’s news releases is its scientific and investor outreach. The company reports oral and poster presentations at major liver and gastroenterology meetings, including Digestive Disease Week, BSG Live, AASLD The Liver Meeting and EASL congresses, where nebokitug data and CCL24-related mechanisms are discussed. Chemomab also announces participation in rare disease summits and global investment conferences, along with corporate updates tied to quarterly financial results, patent awards and capital markets activities such as at-the-market equity offerings or ADS ratio adjustments.
Readers of the CMMB news page on Stock Titan can use this stream of clinical, regulatory and corporate announcements to track Chemomab’s progress with nebokitug in PSC and other fibro-inflammatory indications, as well as to monitor key events that may influence the company’s development plans and regulatory trajectory.
Chemomab Therapeutics (Nasdaq: CMMB) has successfully closed a $10 million private placement, extending its cash runway potentially to early 2026. The financing, which involved both existing and new investors including HBM Healthcare Investments, OrbiMed, and Sphera Biotech Master Fund LP, positions the company to achieve key clinical milestones in Q1 2025 while advancing discussions with potential partners based on positive Phase 2 results.
The private placement involved the sale of 8,097,167 ADSs and pre-funded warrants at a price of $1.235 per ADS, without warrant coverage. Oppenheimer & Co. Inc. acted as Capital Markets Advisor, with LifeSci Capital and Maxim Group also advising. The company has agreed to file a registration statement with the SEC for the resale of the issued securities.
Chemomab Therapeutics (Nasdaq: CMMB), a clinical-stage biotech company focusing on fibro-inflammatory diseases, has regained compliance with Nasdaq's minimum bid price requirement. The company received a notification letter from Nasdaq confirming that it has met the closing bid price of $1.00 or greater for 10 consecutive business days from July 9 to July 22, 2024. This resolves the non-compliance issue initially reported on November 6, 2023, when Chemomab's American Depositary Shares (ADSs) had fallen below the $1.00 threshold for more than 30 consecutive business days. With this development, Nasdaq has closed the matter, affirming Chemomab's continued listing on the exchange.
Chemomab Therapeutics (Nasdaq: CMMB) has announced a $10 million private placement (PIPE) with participation from new and existing investors. The company is selling 4,188,867 American Depositary Shares at $1.235 per share and pre-funded warrants to purchase up to 3,908,300 ADSs. This funding is expected to extend Chemomab's cash runway through early 2026, supporting operations for about a year after two major milestones anticipated in early 2025.
The proceeds will be used to fund development programs for CM-101, their innovative therapeutic for fibro-inflammatory diseases, as well as general corporate purposes. The PIPE is set to close around July 26, 2024, subject to customary closing conditions. Oppenheimer & Co. Inc. is acting as Capital Markets Advisor for the transaction.
Chemomab Therapeutics (Nasdaq: CMMB) has reported positive topline results from its Phase 2 SPRING trial of CM-101, a first-in-class monoclonal antibody, in patients with primary sclerosing cholangitis (PSC). The trial met its primary endpoint of safety and tolerability and demonstrated anti-fibrotic, anti-inflammatory, and anti-cholestatic effects across multiple secondary efficacy endpoints.
Key findings include:
- Statistically significant improvement in liver stiffness, a important PSC disease marker
- Reduction in total bilirubin, an important marker of cholestasis and liver health
- Improvements in pruritis, a cholestatic indicator relevant to patients
- Favorable safety profile and general tolerability over the 15-week treatment period
The company plans to advance CM-101 to a Phase 3 PSC trial in 2025, following discussions with the FDA later this year.
Chemomab Therapeutics announced new publications reinforcing the clinical potential of its CCL24-neutralizing antibody, CM-101, in treating primary sclerosing cholangitis (PSC). A study published in the International Journal of Molecular Science used machine learning to analyze proteomic profiles from PSC patient sera, confirming that high levels of CCL24 are linked to PSC severity and cirrhosis. This highlights the possibility of CM-101 as an effective therapy. A second study in Drug Safety reported that CM-101 showed good tolerability and reduced biomarkers of inflammation and fibrosis in Phase 1 trials. Topline data from the Phase 2 PSC trial is expected mid-2024.
Chemomab Therapeutics shared promising data at EASL 2024 and the Gordon Research Conference, showcasing the potential of CM-101 as a novel treatment for Primary Sclerosing Cholangitis (PSC). The studies highlighted CM-101's anti-fibrotic activity, evidenced by reduced liver fibroblast activation in ex vivo assays using patient samples. New translational data confirmed CM-101's disease-modifying effects in PSC. Proteomic profiling and machine learning developed a protein signature predicting PSC severity, reinforcing the therapeutic targeting of CCL24. These findings are pivotal as Chemomab approaches topline results from its Phase 2 PSC trial.
Chemomab Therapeutics (Nasdaq: CMMB), a clinical-stage biotech firm focusing on fibro-inflammatory diseases, has announced its participation in two significant scientific conferences. At the Gordon Research Conference on Chemotactic Cytokines (June 2-7, 2024, Portland, Maine), Prof. Amnon Peled will present on CCL24's role in liver fibrosis and inflammation. At the EASL Congress 2024 (June 5-8, 2024, Milan, Italy), Chemomab's team will present multiple posters on CM-101's anti-fibrotic activity and its potential for primary sclerosing cholangitis. Chemomab's corporate development team will also attend the BIO International Convention in San Diego (June 3-6, 2024) for partnering opportunities.
Chemomab Therapeutics announced its first quarter 2024 financial results and corporate update, highlighting early completion of patient enrollment in the CM-101 Phase 2 trial for primary sclerosing cholangitis, peer-reviewed publications validating the role of CCL24, and significant catalysts expected in late 2024/early 2025. The company also reported new patents granted in the E.U., Brazil, and Israel, and hosted an expert PSC webinar. Financially, Chemomab's cash position was $16.0 million as of March 31, 2024, with decreased R&D and G&A expenses.
Chemomab Therapeutics (Nasdaq: CMMB) has been granted a 180-day extension by Nasdaq to regain compliance with the minimum bid price rule. The company has until November 4, 2024, to ensure that the closing bid price of its American Depositary Shares (ADSs) is at least $1.00 per ADS for a minimum of 10 consecutive trading days. If the requirement is met, Nasdaq will confirm compliance, allowing Chemomab to maintain its listing on the Nasdaq Capital Market under the symbol 'CMMB'.
Chemomab Therapeutics (Nasdaq: CMMB) will have Dr. Adi Mor, the CEO, present at the Aegis Virtual Conference on May 7, 2024, discussing innovative therapeutics for fibro-inflammatory diseases. The presentation will be webcast live, offering further insights into the company's endeavors.