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Compass Therapeutics Announces Tovecimig Data Accepted for an Oral Presentation at the ESMO Congress 2026

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Compass Therapeutics (Nasdaq: CMPX) reported that its abstract, “A randomized trial of paclitaxel ± tovecimig in previously treated patients with advanced biliary tract cancer,” has been accepted for an oral Proffered Paper presentation at the ESMO Congress 2026 in Madrid, Spain.

The presentation will cover results from the randomized, controlled Phase 2/3 COMPANION-002 trial evaluating tovecimig, a DLL4 x VEGF-A bispecific antibody, in combination with paclitaxel in patients with advanced biliary tract cancer. According to Compass Therapeutics, Dr. Nilofer Azad of Johns Hopkins University will present on Saturday, October 24, 2026, during a session scheduled from 10:15am–11:45am CET.

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News Market Reaction – CMPX

-2.38%
1 alert
-2.38% Session close to close
$385.39M Market Cap
0.0x Rel. Volume

In the Jul 17 session, CMPX declined 2.38%, reflecting a moderate negative market reaction.

Data tracked by StockTitan Argus on the day of publication.

Market Context

Set against a history where four of five recent news events aligned with price direction and one maj...
Analysis

Set against a history where four of five recent news events aligned with price direction and one major COMPANION-002 release diverged sharply, this ESMO oral notice slots into an evolving BTC story. High short interest and recent insider net buying of 40,000 shares frame a tug-of-war between skeptics and insiders that future detailed data at Madrid may clarify.

Key Figures

ESMO 2026 dates: October 23–27, 2026 Oral presentation date: Saturday, October 24, 2026 Session time: 10:15am – 11:45am CET
3 metrics
ESMO 2026 dates October 23–27, 2026 ESMO Congress schedule in Madrid, Spain
Oral presentation date Saturday, October 24, 2026 Scheduled COMPANION-002 tovecimig presentation at ESMO
Session time 10:15am – 11:45am CET Tovecimig COMPANION-002 oral session at ESMO

Historical Context

5 past events · Latest: May 28 (Neutral)
Pattern 5 events
Date Event Sentiment 24h Move Catalyst
May 28 Investor conferences Neutral +6.2% Participation in June 2026 healthcare investor conferences with webcast access.
May 21 Phase 1 clinical data Positive +7.3% Promising CTX-8371 Phase 1 data with responses in advanced malignancies.
May 12 Investor conferences Neutral +2.2% May 2026 biotechnology and oncology conference participation notice.
May 05 Q1 2026 earnings Positive +0.5% Quarterly results plus positive tovecimig data and strong cash runway.
Apr 27 Phase 2/3 trial results Positive -64.4% COMPANION-002 BTC study met ORR and PFS endpoints with significant benefit.

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Pattern Detected

Recent news has usually aligned with the share reaction, with one notable divergence on the initial COMPANION-002 data release.

Key Terms

randomized trial, phase 2/3, bispecific antibody
3 terms
randomized trial medical
"A randomized trial of paclitaxel ± tovecimig in previously treated patients"
A randomized trial is a study where participants are assigned by chance—like flipping a coin—to different treatments or to a comparison group so the results reflect the effect of the treatment rather than other factors. Investors care because these trials provide the most reliable evidence about whether a drug, device, or strategy works, and strong, clear results can change a company’s approval prospects, market size and risk profile quickly.
phase 2/3 medical
"results of the randomized, controlled Phase 2/3 COMPANION-002 clinical trial"
A phase 2/3 trial is a combined clinical study that first evaluates how well a treatment works and the best dose, then expands into a larger test to confirm those results and safety. For investors, it matters because moving into a phase 2/3 signals that an experimental therapy has shown initial promise and will be tested at scale, which can materially change the odds and timeline for regulatory approval and commercial potential.
bispecific antibody medical
"tovecimig (a DLL4 x VEGF-A bispecific antibody) in combination with paclitaxel"
A bispecific antibody is a specially designed protein that can attach to two different targets at the same time. Think of it as a custom-made connector that brings two things together—such as a disease cell and an immune system component—helping the body fight illnesses more effectively. For investors, understanding bispecific antibodies is important because they represent innovative therapies that could lead to new treatments and potentially lucrative market opportunities.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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BOSTON, July 17, 2026 (GLOBE NEWSWIRE) -- Compass Therapeutics, Inc. (Nasdaq: CMPX), a clinical-stage, oncology-focused biopharmaceutical company developing proprietary antibody-based therapeutics to treat multiple human diseases, today announced that its abstract titled “A randomized trial of paclitaxel ± tovecimig in previously treated patients with advanced biliary tract cancer” has been accepted for an oral Proffered Paper presentation at the upcoming European Society for Medical Oncology (ESMO) Congress. The congress will take place October 23-27, 2026 in Madrid, Spain.

The presentation will highlight the results of the randomized, controlled Phase 2/3 COMPANION-002 clinical trial assessing tovecimig (a DLL4 x VEGF-A bispecific antibody) in combination with paclitaxel in patients with advanced biliary tract cancer (BTC) and will be presented by Dr. Nilofer Azad, MD, FASCO, Professor of Oncology, Associate Director of Clinical Research, Sidney Kimmel Cancer Center at Johns Hopkins University.

Presentation: Saturday, October 24, 2026
Session time: 10:15am – 11:45am CET

Additional details regarding the presentation will be made available in accordance with ESMO Congress policies.

About Compass Therapeutics
Compass Therapeutics, Inc. was founded in 2014 and is headquartered in Boston, MA. Compass is a clinical-stage, oncology-focused biopharmaceutical company discovering and developing proprietary antibody-based therapeutics to treat multiple diseases. The company’s scientific focus is on the relationship between angiogenesis, the immune system, and tumor growth. Compass has a robust pipeline of novel product candidates designed to target multiple key biological pathways to drive an effective anti-tumor response, including angiogenesis modulation, immune activation within the tumor microenvironment, and reduction of tumor-driven immunosuppression. The company is advancing discovery candidates through clinical development to commercial-stage assets. For more information, visit www.compasstherapeutics.com.

Forward-Looking Statements

This press release contains forward-looking statements. Statements in this press release that are not purely historical are forward-looking statements. Such forward-looking statements include, among other things, references to Compass’s financial position to continue advancing its product candidates, expectations about cash runway, business and development plans, and statements regarding Compass’s product candidates, including their development and clinical trial milestones such as the expected trial design, timing of enrollment, patient dosing and data readouts, regulatory plans with respect to Compass’s product candidates and the therapeutic potential thereof. Actual results could differ from those projected in any forward-looking statements due to numerous factors. Such factors include, among others, Compass’s ability to raise the additional funding it will need to continue to pursue its business and product development plans, the inherent uncertainties associated with developing product candidates and operating as a development stage company, Compass’s ability to identify additional product candidates for development, Compass’s ability to develop, complete clinical trials for, obtain approvals for and commercialize any of its product candidates, competition in the industry in which Compass operates and market conditions. These forward-looking statements are made as of the date of this press release, and Compass assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those projected in the forward-looking statements, except as required by law. Investors should consult all of the information set forth herein and should also refer to the risk factor disclosure set forth in the reports and other documents Compass files with the U.S. Securities and Exchange Commission (SEC) available at www.sec.gov, including without limitation Compass’s latest Annual Report on Form 10-K, Quarterly Report on Form 10-Q and subsequent filings with the SEC.

Investor Contact
ir@compasstherapeutics.com

Media Contact
Anna Gifford, Chief of Staff
media@compasstherapeutics.com
617-500-8099 


FAQ

What did Compass Therapeutics (CMPX) announce about tovecimig at ESMO Congress 2026?

Compass Therapeutics announced that an abstract on tovecimig in advanced biliary tract cancer was accepted for an oral Proffered Paper at ESMO Congress 2026. According to Compass Therapeutics, the talk will present randomized Phase 2/3 COMPANION-002 trial results in previously treated biliary tract cancer patients.

When will Compass Therapeutics present tovecimig Phase 2/3 data at ESMO Congress 2026?

Compass Therapeutics plans to present tovecimig Phase 2/3 data on Saturday, October 24, 2026, at ESMO Congress 2026. According to Compass Therapeutics, the session featuring the COMPANION-002 trial results is scheduled from 10:15am to 11:45am CET in Madrid, Spain.

What is the COMPANION-002 trial of tovecimig described by Compass Therapeutics (CMPX)?

COMPANION-002 is a randomized, controlled Phase 2/3 trial evaluating paclitaxel with or without tovecimig in advanced biliary tract cancer. According to Compass Therapeutics, the study assesses a DLL4 x VEGF-A bispecific antibody combined with paclitaxel in previously treated patients with advanced biliary tract cancer.

What type of drug is tovecimig in the Compass Therapeutics biliary tract cancer trial?

Tovecimig is described as a DLL4 x VEGF-A bispecific antibody being tested with paclitaxel in advanced biliary tract cancer. According to Compass Therapeutics, this antibody-based therapeutic is evaluated in the randomized Phase 2/3 COMPANION-002 trial in previously treated biliary tract cancer patients.

Who will present the Compass Therapeutics tovecimig data for CMPX at ESMO 2026?

The tovecimig data will be presented by Dr. Nilofer Azad, MD, FASCO, from Johns Hopkins University. According to Compass Therapeutics, Dr. Azad is a Professor of Oncology and Associate Director of Clinical Research at the Sidney Kimmel Cancer Center and will deliver the oral presentation.

Where will Compass Therapeutics’ tovecimig COMPANION-002 results be presented during ESMO Congress 2026?

The tovecimig COMPANION-002 results will be presented at the ESMO Congress 2026 in Madrid, Spain. According to Compass Therapeutics, the oral Proffered Paper session for the randomized Phase 2/3 biliary tract cancer trial is scheduled on October 24, 2026, between 10:15am and 11:45am CET.