Compass Therapeutics, Inc. develops clinical-stage, oncology-focused antibody therapeutics targeting angiogenesis, immune activation and tumor-driven immunosuppression. News about CMPX centers on its antibody pipeline, including tovecimig, a DLL4 x VEGF-A bispecific antibody studied with paclitaxel in biliary tract cancer, and earlier-stage programs such as CTX-8371, CTX-10726 and CTX-471.
Recurring updates cover clinical trial results, FDA-related regulatory designations and interactions, medical-meeting presentations, pipeline expansion, financial results, cash resources, leadership changes and equity inducement grants under Nasdaq rules.
Compass Therapeutics, Inc. (CMPX) announced the FDA's approval of the investigational new drug application for CTX-009, allowing an expansion to a global Phase 2 study in biliary tract cancer. Interim data indicated a 42% overall response rate (ORR) and a 92% clinical benefit rate (CBR) among the first 24 patients. The CTX-471 Phase 1b study reported 3 partial responses. As of March 31, 2022, the company had $136.4 million in cash, anticipated to fund operations into late 2024, with a reduced net loss of $7.2 million for Q1 2022, compared to $7.3 million in Q1 2021.
Compass Therapeutics, a clinical-stage biopharmaceutical company focused on antibody-based cancer treatments, announced that CEO Thomas J. Schuetz will present at the Bank of America Securities 2022 Healthcare Conference. The event is set for May 12, 2022, at 11:20 AM PT in Las Vegas. The presentation will be available live and replayed 24 hours post-event on the company's website. Compass is dedicated to developing therapies targeting critical biological pathways essential for effective anti-tumor responses.
Compass Therapeutics (Nasdaq: CMPX) announced interim results from its Phase 2 study of CTX-009, revealing a 42% overall response rate (ORR) based on 10 partial responses among 24 patients with biliary tract cancers. The clinical benefit rate reached 92%, with most patients exhibiting stable disease. The drug was well tolerated, aligning with Phase 1 findings. Compass plans to commence the second stage of the study in the U.S. in Q3 2022. The data suggest CTX-009 may offer a new treatment avenue for patients with limited options.
Compass Therapeutics, Inc. (Nasdaq: CMPX) will host a webinar on May 4, 2022, at 8:00 a.m. ET to discuss clinical data from its ongoing Phase 2 trial of CTX-009. A Key Opinion Leader will join the management for this review. The company focuses on developing proprietary antibody-based therapeutics targeting cancer through a unique approach addressing angiogenesis and immune response. The upcoming session aims to provide insights into trial results, with a replay available for six months on the company's website.
Compass Therapeutics, Inc. (Nasdaq: CMPX) announced the appointment of two new directors, Ellen Chiniara and Mary Ann Gray, to its board. Chiniara, former Chief Legal Officer of Alexion Pharmaceuticals, and Gray, President of Gray Strategic Advisors, bring extensive experience in the life sciences and biopharmaceutical sectors. This strategic move aims to enhance Compass's leadership at a critical time for the company. The board believes their skills will support Compass in advancing its clinical pipeline and driving shareholder value.
Compass Therapeutics (CMPX), a clinical-stage oncology company, recently presented promising preclinical data for its bispecific checkpoint inhibitor, CTX-8371, at the AACR Annual Meeting. This innovative therapy targets both PD-1 and PD-L1, showcasing a unique mechanism of action that leads to PD-1 loss on T cells. Key findings indicate significant tumor volume reduction and complete tumor eradication in mouse models. Clinical development of CTX-8371 is projected to start in early 2023, marking a significant step forward in cancer therapeutics.
Compass Therapeutics Inc. (Nasdaq: CMPX) announced its presentation of preclinical data on CTX-8371, a bispecific checkpoint inhibitor targeting PD-1 and PD-L1, at the AACR Annual Meeting from April 8-13, 2022. The study, led by Diana Albu, Ph.D., will showcase the antibody's potential to enhance anti-tumor activity in solid tumors by converting PD-1-positive cells to PD-1-negative cells. As part of IND-enabling preclinical development, CTX-8371 shows promise over existing monoclonal antibodies, indicating its unique mechanism could mitigate immune suppression effectively.
Compass Therapeutics reported a strong financial position with $144.5 million in cash as of 2021, bolstered by a $136 million public offering. The company is advancing its clinical pipeline, particularly the CTX-009 study for advanced biliary tract cancers, which met response criteria for progression to Phase 2. Additionally, CTX-471 showed encouraging results in patients with solid tumors. However, the company faced a net loss of $82.2 million for 2021, with R&D expenses rising significantly to $20.3 million, marking a 36% increase from 2020. The company expects to sustain operations into late 2024.
Compass Therapeutics, Inc. (Nasdaq: CMPX) announced the FDA has cleared its IND application for CTX-009, enabling a global Phase 2 trial for Biliary Tract Cancers (BTC) in the U.S. and South Korea. CTX-009 is a bispecific antibody targeting DLL4 and VEGF-A, showing clinical benefit in heavily pre-treated patients. The ongoing Phase 2 study in South Korea has completed Stage 1, achieving a 29% overall response rate and a 100% clinical benefit rate. Expansion to U.S. sites is planned for Q2 2022, presenting potential growth opportunities for the company.
Compass Therapeutics, Inc. (Nasdaq: CMPX) announced that CEO Thomas Schuetz will present at the 40th Annual J.P. Morgan Healthcare Conference on January 12, 2022, from 8:15 to 8:55 a.m. ET. The presentation will be virtual, with details to be updated on the company's investor webpage. Compass Therapeutics focuses on antibody-based therapeutics for cancer treatment, exploring the interplay between angiogenesis, the immune system, and tumor growth. Established in 2014 and based in Boston, Massachusetts, the company aims to advance its innovative pipeline through clinical development.