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CENTOGENE Extends Strategic Partnership With Takeda to Continue Providing Access to Genetic Testing for Patients With Lysosomal Storage Disorders

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Centogene N.V. extends partnership with Takeda to provide efficient diagnosis for Lysosomal Storage Disorders globally, emphasizing rapid and reliable diagnostics for diseases like Fabry disease, Gaucher disease, and Hunter syndrome.
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The extension of the partnership between CENTOGENE and Takeda is a strategic move that reinforces the commitment of both companies to address the diagnostic challenges associated with Lysosomal Storage Disorders (LSDs). This collaboration is poised to streamline the diagnostic process for patients worldwide, which can lead to earlier treatment initiation and potentially improved patient outcomes. For investors, such partnerships often signify a sustained revenue stream for the diagnostic company and can enhance the market position of the pharmaceutical partner by associating it with improved patient care.

From a market perspective, the focus on rare and neurodegenerative diseases is a growing niche within the healthcare sector. The rarity of these conditions often leads to high treatment costs, which can translate into significant profits for companies that offer effective solutions. The partnership also reflects a broader industry trend towards personalized medicine, where treatments are tailored to the genetic profile of individual patients, potentially leading to more efficient healthcare spending and better health economics.

However, the impact on Takeda's and CENTOGENE's stock performance will depend on the operational execution of this partnership and the actual market demand for these diagnostic services. Investors should monitor the uptake of the testing services and any data on improved patient outcomes, as these will be key drivers of the financial success of the agreement.

Lysosomal Storage Disorders are a group of rare, inherited metabolic disorders that can lead to a range of health problems. The partnership's emphasis on rapid and reliable diagnostics is critical because early detection and treatment of LSDs can significantly alter the course of the disease and improve quality of life. Therefore, the extended collaboration between CENTOGENE and Takeda has the potential to fill an unmet need in the medical community.

Investors should be aware that the rare disease market is highly specialized and the number of patients is relatively small. However, the treatments for these conditions are often very expensive and insurance companies are usually willing to cover these costs due to the lack of alternative therapies. This means that successful diagnostic tools can command high prices and generate substantial profit margins.

It's important to note that while the partnership is promising, the actual impact on the companies' bottom lines will be contingent upon the prevalence of LSDs, the global reach of the diagnostic services and the ability of healthcare providers to act on the diagnostic information provided by CENTOGENE's tests.

The extension of the partnership between CENTOGENE and Takeda is a noteworthy development for shareholders and potential investors. It signals confidence in CENTOGENE's diagnostic capabilities and suggests that Takeda sees value in continuing to invest in this area. The partnership could lead to increased testing volumes, which in turn would drive revenue growth for CENTOGENE. For Takeda, the agreement may enhance its competitive edge in the rare disease market by ensuring a pipeline of diagnosed patients who may be candidates for their therapies.

While the immediate financial impact may not be substantial due to the low prevalence of LSDs, the long-term potential for both companies is significant. The ability to diagnose and treat rare diseases effectively can lead to strong patient loyalty and a defensible niche market. Additionally, partnerships like this can attract further collaborations and investments, potentially leading to a positive feedback loop that benefits both the business operations and stock valuations of the companies involved.

Investors should also consider the potential risks, such as regulatory hurdles, the complexity of the diseases involved and the possibility of new competitors entering the market. These factors could influence the future success of the partnership and should be factored into any investment decisions related to CENTOGENE and Takeda.

  • Longstanding global partnership provides an efficient and timely diagnosis to patients with Lysosomal Storage Disorders (LSDs)

CAMBRIDGE, Mass. and ROSTOCK, Germany and BERLIN, March 19, 2024 (GLOBE NEWSWIRE) -- Centogene N.V. (Nasdaq: CNTG), the essential life science partner for data-driven answers in rare and neurodegenerative diseases, today announced the extension of an ongoing partnership with Takeda (TSE: 4502/NYSE: TAK) to diagnose patients with Lysosomal Storage Disorders (LSDs).

Under the renewed agreement, CENTOGENE will continue to provide Takeda with access to diagnostic testing for patients around the world. The agreement was established to enhance patient access to rapid and reliable diagnostics for LSDs, including Fabry disease, Gaucher disease, and Hunter syndrome.

“Extending our longstanding partnership with Takeda highlights the continuing need to accelerate diagnoses for LSD patients globally and the ability of CENTOGENE to fulfill this vital service,” said Ian Rentsch, CENTOGENE Chief Commercial Officer and General Manager - Pharma. “Leveraging our targeted genomic and multiomic testing portfolio, we are uniquely positioned to deliver improved health outcomes for underserved patient communities, particularly in the rare disease sector.”

“We believe that great solutions require great collaboration,” said Kim Stratton, Chief Executive Officer at CENTOGENE. “From long standing partners like Takeda to new partners like Lifera, a biopharmaceutical company wholly-owned by the Public Investment Fund (PIF) in Saudi Arabia, we are committed to teaming up with global players to deliver life-changing answers to rare and neurodegenerative disease patients around the world.”

In January 2015, CENTOGENE originally entered into an agreement with Shire Pharmaceuticals, which was acquired in 2019 by Takeda, to provide diagnostic testing capability to enhance early diagnosis of patients suffering from rare genetic diseases.

About CENTOGENE

CENTOGENE’s mission is to provide data-driven, life-changing answers to patients, physicians, and pharma companies for rare and neurodegenerative diseases. We integrate multiomic technologies with the CENTOGENE Biodatabank – providing dimensional analysis to guide the next generation of precision medicine. Our unique approach enables rapid and reliable diagnosis for patients, supports a more precise physician understanding of disease states, and accelerates and de-risks targeted pharma drug discovery, development, and commercialization.

Since our founding in 2006, CENTOGENE has been offering rapid and reliable diagnosis – building a network of approximately 30,000 active physicians. Our ISO, CAP, and CLIA certified multiomic reference laboratories in Germany utilize Phenomic, Genomic, Transcriptomic, Epigenomic, Proteomic, and Metabolomic datasets. This data is captured in our CENTOGENE Biodatabank, with over 800,000 patients represented from over 120 highly diverse countries, over 70% of whom are of non-European descent. To date, the CENTOGENE Biodatabank has contributed to generating novel insights for more than 285 peer-reviewed publications.

By translating our data and expertise into tangible insights, we have supported over 50 collaborations with pharma partners. Together, we accelerate and de-risk drug discovery, development, and commercialization in target and drug screening, clinical development, market access and expansion, as well as offering CENTOGENE Biodata Licenses and Insight Reports to enable a world healed of all rare and neurodegenerative diseases.

To discover more about our products, pipeline, and patient-driven purpose, visit www.centogene.com and follow us on LinkedIn.

Forward-Looking Statements

This press release contains “forward-looking statements” within the meaning of the U.S. federal securities laws. Statements contained herein that are not clearly historical in nature are forward-looking, and the words “anticipate,” “believe,” “continues,” “expect,” “estimate,” “intend,” “project,” “plan,” “is designed to,” “potential,” “predict,” “objective” and similar expressions and future or conditional verbs such as “will,” “would,” “should,” “could,” “might,” “can,” and “may,” or the negative of these are generally intended to identify forward-looking statements. Such forward-looking statements involve known and unknown risks, uncertainties, and other important factors that may cause CENTOGENE’s actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the possibility that no strategic alternatives or trading market will be available to CENTOGENE, negative economic and geopolitical conditions and instability and volatility in the worldwide financial markets, possible changes in current and proposed legislation, regulations and governmental policies, pressures from increasing competition and consolidation in our industry, the expense and uncertainty of regulatory approval, including from the U.S. Food and Drug Administration, our reliance on third parties and collaboration partners, including our ability to manage growth, execute our business strategy and enter into new client relationships, our dependency on the rare disease industry, our ability to manage international expansion, our reliance on key personnel, our reliance on intellectual property protection, fluctuations of our operating results due to the effect of exchange rates, our ability to streamline cash usage, our continued ongoing compliance with covenants linked to financial instruments, our requirement for additional financing, and our ability to continue as a going concern, or other factors. For further information on the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to CENTOGENE’s business in general, see CENTOGENE’s risk factors set forth in CENTOGENE’s Form 20-F filed on May 16, 2023, with the Securities and Exchange Commission (the “SEC”) and subsequent filings with the SEC. Any forward-looking statements contained in this press release speak only as of the date hereof, and CENTOGENE specifically disclaims any obligation to update any

CONTACT

CENTOGENE

Melissa Hall
Corporate Communications
Press@centogene.com

Lennart Streibel
Investor Relations
IR@centogene.com


Centogene N.V. announced the extension of its partnership with Takeda to diagnose patients with Lysosomal Storage Disorders.

The partnership extension focuses on diagnosing diseases like Fabry disease, Gaucher disease, and Hunter syndrome.

CENTOGENE originally entered into an agreement with Shire Pharmaceuticals in January 2015.

Ian Rentsch is the Chief Commercial Officer and General Manager - Pharma at CENTOGENE.

CENTOGENE leverages targeted genomic and multiomic testing portfolio for improved health outcomes.

Takeda acquired Shire Pharmaceuticals in 2019.
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centogene is a worldwide leader in the field of genetic diagnostic testing for rare hereditary diseases, with a broad test portfolio covering over 2800 genes, biochemical tests, biomarker tests, clinical whole exome sequencing and whole genome sequencing. centogene’s mission is to support medical professionals with in-depth medical expertise in order to diagnose early the cause of the patients’ symptoms. analyzing samples from all over the world allows centogene to constantly expand its unique portfolio resulting in the largest systematic documentation of genetic results, centomd®. this mutation database integrates genetic and clinical information, enabling the highest quality, knowledge-based genetic testing and biomarker development. in addition to offering diagnostic services for individual patients, centogene is a pivotal partner to some of the most respected names in the industry. imprint centogene ag is a stock corporation ('aktiengesellschaft') incorporated under the