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Cogent Biosciences Announces Bezuclastinib Poster in NonAdvanced Systemic Mastocytosis (NonAdvSM) at the 2025 AAAAI Annual Meeting

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Cogent Biosciences (Nasdaq: COGT) has announced an upcoming poster presentation featuring bezuclastinib at the 2025 American Academy of Allergy Asthma & Immunology Annual Meeting (AAAAI) in San Diego. The presentation will focus on a subgroup of patients who received 100mg bezuclastinib for at least 48 weeks in the ongoing Summit Trial, highlighting long-term symptomatic benefits.

The poster, titled 'Efficacy and Safety Results of Adult Patients with NonAdvanced Systemic Mastocytosis Receiving Bezuclastinib 100 mg in the Ongoing Summit Trial: A Randomized, Double-Blind, Placebo Controlled Phase 2 Clinical Trial of Bezuclastinib,' will be presented on March 1, 2025, from 9:45-10:45am PT at the San Diego Convention Center.

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WALTHAM, Mass. and BOULDER, Colo., Feb. 10, 2025 (GLOBE NEWSWIRE) -- Cogent Biosciences, Inc. (Nasdaq: COGT), a biotechnology company focused on developing precision therapies for genetically defined diseases, today announced an upcoming poster for bezuclastinib at the 2025 American Academy of Allergy Asthma & Immunology Annual Meeting (AAAAI) being held in San Diego, CA, February 28-March 3, 2025.

The focus of the presentation will be on the subgroup of patients who have received 100mg bezuclastinib for at least 48 weeks to highlight the symptomatic benefits of long-term use.

Poster Details

Poster Presentation Title: Efficacy and Safety Results of Adult Patients with NonAdvanced Systemic Mastocytosis Receiving Bezuclastinib 100 mg in the Ongoing Summit Trial: A Randomized, Double-Blind, Placebo Controlled Phase 2 Clinical Trial of Bezuclastinib
Session Date and Time: March 1, 2025 – 9:45am – 10:45am PT (12:45pm – 1:45pm ET)
Session Title: Novel Mechanisms of Mast Cells, Basophils and IgE
Poster Number: 520
Location: San Diego Convention Center, Ground Level, Hall A

About Cogent Biosciences, Inc.
Cogent Biosciences is a biotechnology company focused on developing precision therapies for genetically defined diseases. The most advanced clinical program, bezuclastinib, is a selective tyrosine kinase inhibitor that is designed to potently inhibit the KIT D816V mutation as well as other mutations in KIT exon 17. KIT D816V is responsible for driving systemic mastocytosis, a serious disease caused by unchecked proliferation of mast cells. Exon 17 mutations are also found in patients with advanced gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. The company also has an ongoing Phase 1 study of its novel internally discovered FGFR2 inhibitor. In addition, the Cogent Research Team is developing a portfolio of novel targeted therapies to help patients fighting serious, genetically driven diseases targeting mutations in ErbB2, PI3Kα and KRAS. Cogent Biosciences is based in Waltham, MA and Boulder, CO. Visit our website for more information at www.cogentbio.com. Follow Cogent Biosciences on social media: X (formerly known as Twitter) and LinkedIn. Information that may be important to investors will be routinely posted on our website and X.

Contact:
Christi Waarich
Senior Director, Investor Relations
christi.waarich@cogentbio.com
617-830-1653


FAQ

What are the key findings from Cogent Biosciences' (COGT) bezuclastinib Summit Trial in NonAdvanced Systemic Mastocytosis?

The findings will be presented at the 2025 AAAAI Annual Meeting on March 1, 2025, focusing on patients who received 100mg bezuclastinib for at least 48 weeks in the Phase 2 clinical trial.

When and where will Cogent Biosciences (COGT) present their bezuclastinib trial results?

The results will be presented on March 1, 2025, from 9:45-10:45am PT at the San Diego Convention Center during the 2025 AAAAI Annual Meeting.

What is the dosage and duration of bezuclastinib treatment being studied in COGT's Summit Trial?

The study focuses on patients who received 100mg bezuclastinib for at least 48 weeks in the Phase 2 clinical trial.

What type of clinical trial is the COGT Summit Trial for bezuclastinib?

The Summit Trial is a randomized, double-blind, placebo-controlled Phase 2 clinical trial studying bezuclastinib in NonAdvanced Systemic Mastocytosis.
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