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Corbus Pharmaceuticals Holdings, Inc. reports clinical-stage drug-development news in oncology and obesity. Updates center on CRB-701, a next-generation Nectin-4 antibody-drug conjugate licensed from CSPC Megalith Biopharmaceutical, including data presentations in head and neck squamous cell carcinoma and cervical cancer, FDA interactions and Fast Track designations.
Company news also covers CRB-913, a peripherally restricted oral CB1 inverse agonist for obesity, and CRB-601, an anti-integrin monoclonal antibody targeting TGFβ activation. Recurring items include clinical trial disclosures, medical-meeting presentations, management conference appearances, governance changes and operating or financial results.
Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) announced that CEO Yuval Cohen, Ph.D., will present a corporate update and engage in one-on-one investor meetings at the Oppenheimer 33rd Annual Healthcare Conference, hosted virtually from March 13-15, 2023.
The presentation is scheduled for March 14, 2023, at 9:20 a.m. ET. Investors can access the webcast here.
Corbus focuses on precision oncology, with key products including CRB-701 and CRB-601 targeting cancer cells.
Corbus Pharmaceuticals Holdings has entered an exclusive licensing agreement with CSPC Pharmaceutical Group for the development of CRB-701, an antibody drug conjugate targeting Nectin-4. This drug is being developed for various cancers, including urothelial, lung, breast, and prostate. An upfront payment of $7.5 million will be made to CSPC, with potential milestone payments totaling $685 million. The agreement also includes a 1-for-30 reverse stock split effective February 14, 2023, aimed at maintaining compliance with Nasdaq's minimum bid price requirement of $1.00. Corbus aims to initiate US clinical trials in 2024.
Corbus Pharmaceuticals presented new preclinical data for CRB-601, an anti-αvβ8 integrin monoclonal antibody, at the SITC Annual Meeting. CRB-601 shows significant tumor growth inhibition as a single agent and enhances anti-PD-1 therapy effectiveness in various tumor models. Notably, it restores sensitivity in tumors resistant to checkpoint inhibitors. Corbus plans an IND submission for CRB-601 in mid-2023, positioning it as a promising candidate for solid tumor treatment, especially in the context of immune-excluded tumors that currently do not respond to existing therapies.
Corbus Pharmaceuticals Holdings (NASDAQ: CRBP) reported a net loss of $8.8 million for Q3 2022 compared to $2.2 million in Q3 2021, influenced by a prior year tax credit. Operating expenses decreased to $8.2 million from $14.0 million due to reduced clinical trial costs. The company is advancing its CRB-601 therapy, with IND submission planned for mid-2023, and positive pre-clinical data will be presented at SITC 2022. Cash reserves of $67 million are expected to support operations through Q2 2024.
Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) announced a poster presentation at the SITC 2022 Annual Meeting scheduled for November 8-12, 2022. The presentation will highlight the preclinical validation of CRB-601, a selective integrin αvβ8 blocking antibody that shows potent anti-tumor activity in anti-PD-1 resistant models. Investigational New Drug (IND) enabling studies are in progress, with plans to explore its clinical anti-tumor activity in 2023. The poster will be available on the Company's website on November 10.
Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) announced the appointment of Anne Altmeyer, PhD, MBA, MPH to its board of directors. With extensive experience in oncology R&D and corporate development, Altmeyer aims to enhance Corbus' pipeline and business strategies. Currently serving as President and CEO of TigaTx, she has held leadership roles at Sigilon Therapeutics and Novartis, among others. This appointment is expected to drive growth and innovation in developing immune-oncology therapeutics.
Corbus Pharmaceuticals (NASDAQ: CRBP) presented promising preclinical data for its novel oral cannabinoid, CRB-913, at the European Association for the Study of Diabetes 2022 Annual Conference. CRB-913, a CB1 inverse agonist, demonstrated significant anti-obesity effects by reducing body weight, fat content, and liver triglycerides in diet-induced obesity mouse models. Notably, CRB-913 enhanced the efficacy of incretin analogues such as liraglutide, semaglutide, and tirzepatide, suggesting a potential for combination therapy that could improve current obesity treatments.
Corbus Pharmaceuticals Holdings (NASDAQ: CRBP) announced that CEO Yuval Cohen will present virtually at the H.C. Wainwright 24th Annual Global Investment Conference from September 12-14, 2022. The presentation will be available on-demand starting September 12, 2022, at 7:00 AM ET for registered attendees, accessible for 30 days on the conference platform. Corbus focuses on immunology and is committed to innovative treatments targeting serious illnesses, with a pipeline that includes anti-integrin monoclonal antibodies and small molecules for the endocannabinoid system.
Corbus Pharmaceuticals Holdings (NASDAQ: CRBP) provided an update, highlighting promising pre-clinical data for CRB-601, showing enhanced anti-tumor activity when combined with anti-PD-1 therapy. The IND submission for CRB-601 is on track for mid-2023. The company reported a net loss of $13.2 million for Q2 2022, improved from $17.1 million year-over-year, with operating expenses significantly reduced. Cash reserves stand at $74 million, expected to sustain operations through Q1 2024. Corbus also explores partnerships for advancing its pipeline and non-dilutive funding.
Corbus Pharmaceuticals (NASDAQ: CRBP) presented new preclinical data for its anti-αvβ8 integrin monoclonal antibody, CRB-601, at the NYAS Frontiers in Cancer Immunotherapy Conference. The data highlight CRB-601's significant anti-tumor effects, both as a standalone treatment and in combination with anti-PD-1 therapy, across various tumor models including immune-excluded ones. Notably, CRB-601 enhances T-cell proliferation and re-sensitizes tumors to checkpoint inhibition. The company is advancing towards an IND submission in the first half of 2023.