Welcome to our dedicated page for Cardiff Oncology news (Ticker: CRDF), a resource for investors and traders seeking the latest updates and insights on Cardiff Oncology stock.
Cardiff Oncology, Inc. develops clinical-stage cancer therapies centered on PLK1 inhibition and its lead oral inhibitor onvansertib. Company news commonly covers onvansertib in RAS-mutated metastatic colorectal cancer, including the CRDF-004 Phase 2 program evaluating combinations with standard-of-care regimens such as FOLFIRI/bevacizumab and FOLFOX/bevacizumab.
Updates also include preclinical and investigator-initiated work in other oncology settings, including metastatic pancreatic ductal adenocarcinoma, small cell lung cancer, triple-negative breast cancer, HER2-low breast cancer models and chronic myelomonocytic leukemia. Corporate releases also address oncology conference presentations, key opinion leader events, executive appointments, investor conferences and Nasdaq inducement equity grants.
On February 24, 2021, Cardiff Oncology (Nasdaq: CRDF) announced CEO Dr. Mark Erlander's participation in the Cowen 41st Annual Health Care Conference from March 1-4, 2021. He will join a panel discussion on GI Oncology and Pancreatic Cancer on March 2nd, from 9:50 to 10:50 am ET. Cardiff Oncology is focused on developing treatments for cancers with significant medical needs, particularly utilizing its investigational drug, onvansertib, for various cancers including KRAS-mutated colorectal cancer and pancreatic cancer.
Cardiff Oncology (Nasdaq: CRDF), a clinical-stage biotechnology company, is set to present at the LifeSci Partners Precision Oncology Day on February 17, 2021. The presentation, led by CEO Mark Erlander, will focus on the company’s innovative cancer treatment, onvansertib, aimed at addressing high-need conditions like KRAS-mutated colorectal and pancreatic cancer. One-on-one meetings will also occur. A replay of the presentation will be available on their website post-event.
Cardiff Oncology (Nasdaq: CRDF) presented updated results from its Phase 2 trial targeting metastatic castrate-resistant prostate cancer (mCRPC) at the ASCO-GU symposium. The trial evaluated the combination of onvansertib, abiraterone, and prednisone, showing a significant increase in the disease control rate (DCR) from 29% to 63% when treatment days were optimized from 5 to 14. With 75% of patients in the optimized cohort achieving stable disease at 12 weeks, the trial appears poised to meet its primary endpoint of 30% DCR. The study's findings suggest potential for enhanced patient outcomes in this challenging cancer subtype.
Cardiff Oncology (Nasdaq: CRDF) announced FDA approval to begin a Phase 2 clinical trial for onvansertib in patients with metastatic pancreatic ductal adenocarcinoma (PDAC). This trial will assess the combination of onvansertib, nanoliposomal irinotecan, leucovorin, and 5-FU as a second-line treatment for patients who failed prior gemcitabine therapy. Approximately 40 patients will be enrolled across six U.S. sites, including Mayo Clinic locations. The trial aims to evaluate safety and efficacy, with overall response rate as the primary endpoint.
On January 15, 2021, Cardiff Oncology (Nasdaq: CRDF) presented data on its investigational drug, onvansertib, at the ASCO-GI symposium. The Phase 1b/2 trial in KRAS-mutated metastatic colorectal cancer (mCRC) confirmed the recommended Phase 2 dose at 15 mg/m2. Notable outcomes included a 42% partial response rate and 67% of patients showing durable responses lasting over 6 months. Initial findings from the Expanded Access Program mirrored these results, with 66% of patients demonstrating tumor shrinkage. The trial involves collaboration with prominent cancer centers.
Cardiff Oncology (Nasdaq: CRDF) announced the immediate resignation of Dr. Thomas Adams as Executive Chairman and Chairman of the Board, effective December 21, 2020. Dr. Rodney Markin has been appointed as the new Chairman. The board expressed gratitude for Dr. Adams' twelve years of leadership, which facilitated the company's transition from molecular diagnostics to drug development. With ongoing clinical programs targeting KRAS-mutated colorectal cancer, castration-resistant prostate cancer, and acute myeloid leukemia, the company aims to enhance treatment options for patients in need.
Cardiff Oncology (Nasdaq: CRDF) announced updated data from its Phase 1b/2 trial of onvansertib for relapsed/refractory acute myeloid leukemia (AML) at the 62nd ASH Annual Meeting. The oral presentation revealed that 20% of 45 patients achieved complete remission (CR/CRi), with 55% of responders having splicing factor mutations. Notably, the treatment showed promising safety and tolerability, with decreases in mutant ctDNA correlating with clinical responses. This data emphasizes onvansertib's potential impact in treating AML, addressing unmet medical needs.
Cardiff Oncology (Nasdaq: CRDF), a clinical-stage biotechnology company focused on developing cancer treatments, will participate in the Piper Sandler 32nd Annual Virtual Healthcare Conference. A pre-recorded fireside chat with the company's management will be available from November 23 to December 3. Additionally, Cardiff Oncology will conduct 1x1 meetings from December 1 to 3, requested exclusively through Piper Sandler. The company's investigational drug, onvansertib, targets multiple cancers, including KRAS-mutated colorectal cancer and castration-resistant prostate cancer.
Cardiff Oncology, Inc. (Nasdaq: CRDF) reported third quarter highlights and financial results for the period ending September 30, 2020. Key achievements include positive clinical data for onvansertib in treating KRAS-mutated colorectal cancer at the ESMO conference, showcasing a 91% disease control rate among participants. The company raised approximately $100 million from a public stock offering, enhancing its financial position for ongoing and new projects. As of September 30, it held $36.4 million in cash, with total operating expenses of $4.5 million for the quarter.
Cardiff Oncology (Nasdaq: CRDF) announced positive findings from its Phase 2 trial of onvansertib for metastatic castration-resistant prostate cancer (mCRPC) at the 27th Annual PCF Scientific Retreat. The trial showed that 31% of evaluable patients achieved disease control after 12 weeks, with a durable response noted in several cases. A gene signature biomarker was identified to predict patient response to the drug in combination with Zytiga® (abiraterone). Safety data indicated no significant issues across varying doses, reinforcing the potential of onvansertib to address drug resistance in mCRPC.