Crinetics Pharmaceuticals Stock Price, News & Analysis

Crinetics Pharmaceuticals (CRNX) announced positive initial results from the Phase 1 clinical trial of CRN04777, a novel treatment for congenital hyperinsulinism. The trial demonstrated dose-dependent reductions in insulin secretion in healthy volunteers, confirming pharmacologic proof-of-concept for CRN04777 as an oral SST5 agonist. This compound is designed to normalize glucose levels in affected patients, with expectations for further clinical development and data from multiple ascending dose cohorts anticipated in Q1 2022. A Webcast to discuss these findings was held on September 15, 2021.

Crinetics Pharmaceuticals (Nasdaq: CRNX) announced participation in key investor conferences in September 2021. The notable events include the H.C. Wainwright Global Investment Conference from September 13-15, featuring a presentation by CEO Dr. Scott Struthers, and one-on-one meetings on September 13. The SVB Leerink CybeRx Series will take place on September 22-23, where management will also engage in one-on-one meetings. Lastly, the Cantor Fitzgerald Global Healthcare Conference is scheduled for September 27-30, with presentations by Dr. Struthers and CMO Dr. Alan Krasner on September 27.

Crinetics Pharmaceuticals (Nasdaq: CRNX) has appointed Jeff E. Knight as Chief Operating Officer. Knight will oversee strategic management of the company’s operations, leveraging his extensive experience in pharmaceutical portfolio strategy and operations. He previously held roles at Poseida Therapeutics and Amgen. The company is experiencing growth, with ongoing clinical studies for its lead product candidate, paltusotine, and an increase in staff to support its expanding clinical and commercial operations.

Crinetics Pharmaceuticals (CRNX) reported a net loss of $26.1 million for Q2 2021, up from $16.5 million in the same period last year. R&D expenses increased by 63% to $20.5 million due to personnel costs and clinical activities. Positive results were shared from Phase 1 studies of CRN04894, demonstrating significant cortisol suppression, while dosing for the Phase 3 PATHFNDR-1 trial of paltusotine has commenced. The company raised $90 million through stock offerings to strengthen its financial position, with total cash reserves at $203.8 million as of June 30, 2021.

Crinetics Pharmaceuticals (CRNX) has announced promising preliminary results from its Phase 1 study of CRN04894, a first-in-class ACTH antagonist aimed at treating conditions of ACTH excess such as Cushing’s disease. The study demonstrated pharmacologic proof-of-concept, revealing a dose-dependent reduction in cortisol levels among 39 healthy volunteers. CRN04894 effectively suppressed cortisol by 25-56% following ACTH challenges, indicating strong receptor binding. The drug was well tolerated, with mild adverse events reported. A further conference call is scheduled to discuss these results.

Crinetics Pharmaceuticals (Nasdaq: CRNX) announced a private placement of 851,306 shares at $17.62 per share with Frazier Healthcare Partners, generating gross proceeds of $15.0 million. The closing is anticipated on August 2, 2021, pending customary conditions. The funds will support the development of paltusotine and other research programs. Crinetics intends to register the resale of the shares with the SEC. The company specializes in therapeutics for rare endocrine diseases and is advancing multiple investigational drug candidates.

Crinetics Pharmaceuticals (CRNX) announced the randomization of its first acromegaly patient in the Phase 3 clinical trial of paltusotine, known as PATHFNDR-1. This trial aims to evaluate the safety and efficacy of this once-daily oral treatment compared to placebo in patients already controlled by injectable therapies. Successful results could support paltusotine's market registration in the U.S. and Europe. Topline data is anticipated in 2023, marking a significant step toward offering an innovative treatment option for acromegaly patients.

Crinetics Pharmaceuticals (Nasdaq: CRNX) has appointed Garlan Adams as the new General Counsel, a role created to enhance the company’s legal strategies in rare endocrine diseases. Adams brings over two decades of experience in intellectual property and regulatory compliance. CEO Scott Struthers expressed confidence in her ability to support the development of paltusotine for acromegaly. Crinetics is advancing its pipeline, which includes therapies for various endocrine-related conditions.

Crinetics Pharmaceuticals (Nasdaq: CRNX) announced its Q1 2021 financial results and clinical updates. The company has initiated the Phase 3 PATHFNDR program for paltusotine in acromegaly, with studies designed to secure FDA approval for various patient groups. Additionally, CRN04894 and CRN04777 entered Phase 1 trials. Financially, R&D expenses rose to $17.6 million, and net loss increased to $22.9 million for the quarter. Following a successful stock offering in April, the company has $150.7 million in cash, aiming for a steady flow of clinical developments through the remainder of the year.