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Corvus Pharmaceuticals, Inc. (NASDAQ: CRVS) is a pioneering clinical-stage biopharmaceutical company focused on the development of novel immunotherapies to treat a broad spectrum of cancers and immune diseases. The company's core innovation is the selective inhibition of interleukin-2-inducible T cell kinase (ITK), which plays a crucial role in T cell and natural killer (NK) cell immune functions. Corvus' lead investigational product, soquelitinib (formerly CPI-818), has shown promise in optimizing T cell differentiation and enhancing immune responses against tumors, as well as in the management of autoimmune diseases.
Corvus is advancing soquelitinib through a Phase 3 registrational trial for relapsed peripheral T cell lymphoma (PTCL), an aggressive and typically treatment-resistant form of non-Hodgkin’s lymphoma. The company’s focus on ITK inhibition offers a new therapeutic approach, given the lack of FDA-approved treatments for relapsed PTCL. Soquelitinib has demonstrated the ability to prevent T cell exhaustion and promote the generation of cytotoxic killer T cells, critical in cancer therapy.
In addition, Corvus is investigating soquelitinib for other immune-mediated conditions, including atopic dermatitis. The company recently initiated a randomized, double-blind Phase 1 clinical trial to evaluate soquelitinib in patients with moderate to severe atopic dermatitis, aiming to provide an oral treatment alternative to current injectable biologics.
Other promising candidates in Corvus' pipeline include ciforadenant, an adenosine A2A receptor inhibitor that disables tumors' immune evasion mechanisms, and mupadolimab, a monoclonal antibody targeting CD73. These candidates are being studied for their efficacy in combination therapies for various cancers, including head and neck cancers and non-small cell lung cancer.
Financially, Corvus maintains a strong position, having raised significant capital through direct offerings to support its clinical trials and operational needs. With cash reserves projected to fund operations into late 2025, Corvus is well-positioned to achieve substantial milestones in its clinical programs. The company continues to foster critical partnerships, including collaborations with Angel Pharmaceuticals for the Chinese market.
Latest news highlights Corvus' progress in clinical trials and strategic financing moves, underscoring its commitment to bringing innovative immunotherapies to patients in need. For more information, visit the Corvus Pharmaceuticals website.
Corvus Pharmaceuticals (NASDAQ: CRVS) announced the publication of preclinical data in Science Signaling, demonstrating the potential of ITK inhibition with soquelitinib for treating inflammatory diseases. The study, conducted by Cornell University researchers, showed that ITK inhibition induces switching of proinflammatory Th17 cells into anti-inflammatory Treg cells, both in vitro and in vivo.
Key findings include:
- Dose-dependent inhibition of Th17 cell differentiation and increase in Foxp3+ Treg cells
- Switched Foxp3+ Treg cells suppress naïve T cell proliferation
- Significant reduction of Th17 cells in the lung in a mouse model of allergic airway inflammation
This research supports Corvus' view on the broad potential of ITK inhibition for treating autoimmune, allergic, and inflammatory diseases.
Corvus Pharmaceuticals, a clinical-stage biopharmaceutical company listed on NASDAQ under the ticker CRVS, has announced that it will participate in the Jefferies Global Health Conference in New York from June 5-7, 2024. The company's CEO, Richard A. Miller, and Chief Business Officer, Jeffrey Arcara, will present a corporate overview and conduct one-on-one meetings with investors. The presentation is scheduled for June 5 at 3:00 pm ET and will be webcast live, with the recording available for 90 days on the company's investor relations webpage.
Corvus Pharmaceuticals, a clinical-stage biopharmaceutical company, reported strong progress in advancing soquelitinib for PTCL and generating early data for atopic dermatitis. Recent financing provided runway for expected clinical readouts in 2024-2025. Positive Phase 1 trial results for ciforadenant in renal cell cancer. Corvus also collaborates with Kidney Cancer Research Consortium and Angel Pharmaceuticals. Financially, Corvus reported cash, cash equivalents, and marketable securities of $22.1 million as of March 31, 2024, with expected full year 2024 net cash used in operating activities between $24-27 million.
Corvus Pharmaceuticals, Inc. (NASDAQ: CRVS) will provide a business update and report first quarter 2024 financial results on May 6, 2024. The company will host a conference call and webcast at 4:30 pm ET / 1:30 pm PT. Investors can access the call through dial-in numbers or the webcast link. A replay will be available on the company's website.
Corvus Pharmaceuticals has announced a $30.6 million registered direct offering to raise gross proceeds through the sale of common stock and warrants. The offering includes participation from various healthcare investors and existing investors, with the company's CEO also joining. The offering is expected to close on May 6, 2024.
FAQ
What is Corvus Pharmaceuticals' lead product candidate?
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What makes mupadolimab unique in Corvus Pharmaceuticals' research?
