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Corvus Pharmaceuticals Presents Soquelitinib Preclinical Data Highlighting Potential of ITK inhibition to Treat Systemic Sclerosis at EULAR 2025 Congress

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Corvus Pharmaceuticals (NASDAQ: CRVS) announced the presentation of preclinical data for soquelitinib, their lead ITK inhibitor, at the EULAR 2025 Congress in Barcelona. The presentation focuses on the drug's potential to treat systemic sclerosis, with data suggesting it may prevent lung damage, inflammation, and pulmonary hypertension associated with the condition. Dr. Gonçalo Boleto from Centro Académico de Medicina de Lisboa will present the research, which was selected as a top 10 abstract by EMEUNET. While Corvus's primary focus remains on soquelitinib's Phase 3 trial in peripheral T cell lymphoma and Phase 1 trial in atopic dermatitis, the company may explore systemic sclerosis applications through future clinical trials or partnerships.
Corvus Pharmaceuticals (NASDAQ: CRVS) ha annunciato la presentazione di dati preclinici su soquelitinib, il loro principale inibitore ITK, al Congresso EULAR 2025 di Barcellona. La presentazione si concentra sul potenziale del farmaco nel trattamento della sclerosi sistemica, con dati che suggeriscono la capacità di prevenire danni polmonari, infiammazione e ipertensione polmonare associate alla malattia. Il dott. Gonçalo Boleto del Centro Accademico di Medicina di Lisbona presenterà la ricerca, selezionata come uno dei 10 migliori abstract da EMEUNET. Sebbene l'attenzione principale di Corvus rimanga sulla fase 3 del trial di soquelitinib nel linfoma periferico a cellule T e sulla fase 1 nel dermatite atopica, l'azienda potrebbe esplorare applicazioni per la sclerosi sistemica attraverso futuri trial clinici o collaborazioni.
Corvus Pharmaceuticals (NASDAQ: CRVS) anunció la presentación de datos preclínicos sobre soquelitinib, su principal inhibidor de ITK, en el Congreso EULAR 2025 en Barcelona. La presentación se centra en el potencial del fármaco para tratar la esclerosis sistémica, con datos que sugieren que podría prevenir daños pulmonares, inflamación e hipertensión pulmonar asociadas con la enfermedad. El Dr. Gonçalo Boleto del Centro Académico de Medicina de Lisboa presentará la investigación, seleccionada como uno de los 10 mejores resúmenes por EMEUNET. Aunque el enfoque principal de Corvus sigue siendo el ensayo de fase 3 de soquelitinib en linfoma periférico de células T y el ensayo de fase 1 en dermatitis atópica, la compañía podría explorar aplicaciones para la esclerosis sistémica mediante futuros ensayos clínicos o colaboraciones.
Corvus Pharmaceuticals(NASDAQ: CRVS)는 주요 ITK 억제제인 소퀠리티닙의 전임상 데이터를 바르셀로나에서 개최되는 EULAR 2025 학회에서 발표한다고 밝혔습니다. 이번 발표는 전신 경화증 치료 가능성에 초점을 맞추었으며, 데이터는 이 약물이 질환과 관련된 폐 손상, 염증 및 폐고혈압을 예방할 수 있음을 시사합니다. 리스본 학술 의학 센터의 곤살로 볼레토 박사가 연구를 발표하며, 해당 연구는 EMEUNET에서 상위 10개 초록으로 선정되었습니다. Corvus는 주로 말초 T세포 림프종의 3상 임상시험과 아토피 피부염 1상 임상시험에 집중하고 있지만, 향후 임상시험이나 파트너십을 통해 전신 경화증 적용 가능성을 탐색할 계획입니다.
Corvus Pharmaceuticals (NASDAQ : CRVS) a annoncé la présentation de données précliniques sur le soquelitinib, leur principal inhibiteur ITK, lors du Congrès EULAR 2025 à Barcelone. La présentation met en lumière le potentiel du médicament pour traiter la sclérodermie systémique, avec des données suggérant qu'il pourrait prévenir les lésions pulmonaires, l'inflammation et l'hypertension pulmonaire associées à cette maladie. Le Dr Gonçalo Boleto du Centro Académico de Medicina de Lisboa présentera cette recherche, sélectionnée parmi les 10 meilleurs résumés par EMEUNET. Bien que Corvus concentre principalement ses efforts sur l'essai de phase 3 du soquelitinib dans le lymphome périphérique à cellules T et l'essai de phase 1 dans la dermatite atopique, la société pourrait explorer des applications pour la sclérodermie systémique via de futurs essais cliniques ou partenariats.
Corvus Pharmaceuticals (NASDAQ: CRVS) gab die Präsentation präklinischer Daten zu Soquelitinib, ihrem führenden ITK-Inhibitor, auf dem EULAR 2025 Kongress in Barcelona bekannt. Die Präsentation konzentriert sich auf das Potenzial des Medikaments zur Behandlung der systemischen Sklerose, wobei Daten darauf hindeuten, dass es Lungenschäden, Entzündungen und pulmonale Hypertonie, die mit der Erkrankung verbunden sind, verhindern kann. Dr. Gonçalo Boleto vom Akademischen Medizinzentrum Lissabon wird die Forschung vorstellen, die von EMEUNET als eines der Top-10-Abstracts ausgewählt wurde. Während Corvus den Schwerpunkt weiterhin auf die Phase-3-Studie von Soquelitinib bei peripherem T-Zell-Lymphom und die Phase-1-Studie bei atopischer Dermatitis legt, könnte das Unternehmen systemische Sklerose-Anwendungen durch zukünftige klinische Studien oder Partnerschaften erforschen.
Positive
  • Research selected as top 10 abstract by EMEUNET, indicating scientific significance
  • Preclinical data shows potential for preventing multiple systemic sclerosis complications
  • Company has ongoing Phase 3 and Phase 1 trials for other indications
  • Potential for additional partnership opportunities in systemic sclerosis treatment
Negative
  • Still in preclinical stage for systemic sclerosis indication
  • No immediate plans for clinical trials in systemic sclerosis
  • Development for systemic sclerosis dependent on future partnerships or additional resources

SOUTH SAN FRANCISCO, Calif., June 11, 2025 (GLOBE NEWSWIRE) -- Corvus Pharmaceuticals, Inc. (NASDAQ: CRVS), a clinical-stage biopharmaceutical company, today announced preclinical data highlighting the potential of soquelitinib to treat systemic sclerosis will be presented today in a poster session at the European Alliance of Associations for Rheumatology (EULAR) 2025 Congress, which is taking place June 11-14, 2025 in Barcelona. The poster will be presented by Gonçalo Boleto, M.D., MSc, a rheumatologist at Centro Académico de Medicina de Lisboa, Portugal. It was selected as a top 10 abstract by the Emerging EULAR Network (EMEUNET), a network of young rheumatologists and researchers in the field of rheumatology in Europe and beyond.

“There continues to be strong interest in the potential of ITK inhibition to provide a new approach to treating a broad range of diseases, including immune mediated fibrotic diseases such as systemic sclerosis,” said Richard A. Miller, M.D., co-founder, president and chief executive officer of Corvus. “We look forward to presenting preclinical data to the audience at EULAR demonstrating that soquelitinib, our lead ITK inhibitor, may prevent lung damage, inflammation and pulmonary hypertension caused by systemic sclerosis. While our main focus is developing soquelitinib via our registration Phase 3 trial in peripheral T cell lymphoma and Phase 1 trial in atopic dermatitis, we may explore the potential of ITK in systemic sclerosis in future clinical trials or via partnerships.”

Part of the preclinical data being presented at EULAR was previously presented at ACR Convergence 2024, the annual meeting of the American College of Rheumatology.

About Corvus Pharmaceuticals
Corvus Pharmaceuticals is a clinical-stage biopharmaceutical company pioneering the development of ITK inhibition as a new approach to immunotherapy for a broad range of cancer and immune diseases. The Company’s lead product candidate is soquelitinib, an investigational, oral, small molecule drug that selectively inhibits ITK. Its other clinical-stage candidates are being developed for a variety of cancer indications. For more information, visit www.corvuspharma.com or follow the Company on LinkedIn.

Forward-Looking Statements
This press release contains forward-looking statements related to the potential of the Company’s product candidates including soquelitinib, the potential of ITK in systemic sclerosis in future clinical trials or via partnerships, and continued advancement of the Company’s clinical pipeline. All statements other than statements of historical fact contained in this press release are forward-looking statements. These statements often include words such as “believe,” “expect,” “anticipate,” “intend,” “plan,” “estimate,” “seek,” “will,” “may” or similar expressions. Forward-looking statements are subject to a number of risks and uncertainties, many of which involve factors or circumstances that are beyond the Company’s control. The Company’s actual results could differ materially from those stated or implied in forward-looking statements due to a number of factors, including but not limited to, risks detailed in the Quarterly Report on Form 10-Q for the first quarter ended March 31, 2025, filed with the Securities and Exchange Commission on May 8, 2025, as well as other documents that may be filed by the Company from time to time with the Securities and Exchange Commission. In particular, the following factors, among others, could cause results to differ materially from those expressed or implied by such forward-looking statements: the Company’s ability to demonstrate sufficient evidence of efficacy and safety in its clinical trials of its product candidates; the accuracy of the Company’s estimates relating to its ability to initiate and/or complete preclinical studies and clinical trials and release data from such studies and clinical trials; the results of preclinical studies and interim data from clinical trials not being predictive of future results; the Company’s ability to enroll sufficient numbers of patients in its clinical trials; the unpredictability of the regulatory process; regulatory developments in the United States and foreign countries; the costs of clinical trials may exceed expectations; and the Company’s ability to raise additional capital. Although the Company believes that the expectations reflected in the forward-looking statements are reasonable, it cannot guarantee that the events and circumstances reflected in the forward-looking statements will be achieved or occur, and the timing of events and circumstances and actual results could differ materially from those projected in the forward-looking statements. Accordingly, you should not place undue reliance on these forward-looking statements. All such statements speak only as of the date made, and the Company undertakes no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise.

INVESTOR CONTACT:
Leiv Lea
Chief Financial Officer
Corvus Pharmaceuticals, Inc.
+1-650-900-4522
llea@corvuspharma.com

MEDIA CONTACT:
Sheryl Seapy
Real Chemistry
+1-949-903-4750
sseapy@realchemistry.com


FAQ

What is Corvus Pharmaceuticals presenting at EULAR 2025?

Corvus is presenting preclinical data for soquelitinib, their ITK inhibitor, showing its potential to treat systemic sclerosis by preventing lung damage, inflammation, and pulmonary hypertension.

What are the current development stages for CRVS's soquelitinib?

Soquelitinib is in a Phase 3 registration trial for peripheral T cell lymphoma and a Phase 1 trial for atopic dermatitis.

Who is presenting the CRVS research at EULAR 2025?

Dr. Gonçalo Boleto, a rheumatologist from Centro Académico de Medicina de Lisboa, Portugal, is presenting the research.

What recognition did the CRVS research receive at EULAR 2025?

The research was selected as a top 10 abstract by the Emerging EULAR Network (EMEUNET), a network of young rheumatologists and researchers.

What are Corvus Pharmaceuticals' plans for soquelitinib in systemic sclerosis?

Corvus may explore systemic sclerosis applications through future clinical trials or partnerships, but it is not their current primary focus.
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