CytomX Therapeutics Announces 2025 Financial Results and Provides Business Update
Rhea-AI Summary
CytomX (Nasdaq: CTMX) reported 2025 results and a business update on March 16, 2026. Key items: positive Phase 1 Varseta-M data in advanced colorectal cancer, FDA alignment targeted mid‑2026 for a registrational trial, initiated Varseta-M/bevacizumab combination, and CX‑801 combination data expected by end of 2026.
Financials: $137.1M cash at year‑end with runway to Q2 2027, 2025 revenue $76.2M (down from $138.1M), and 2025 operating expense $98.6M.
Positive
- Cash +36% to $137.1M at year‑end 2025
- Positive Varseta‑M Phase 1 data in advanced colorectal cancer
- Operating expense reduced 12.8% year‑over‑year to $98.6M
Negative
- Revenue -45% YoY to $76.2M for 2025
- R&D spend -17% YoY to $68.7M in 2025
- Astellas collaboration terminated, effective Q2 2026
News Market Reaction – CTMX
In the Mar 16 session, CTMX gained 44.23%, reflecting a significant positive market reaction. Argus tracked a peak move of +67.7% during that session. Our momentum scanner triggered 75 alerts that day, indicating high trading interest and price volatility. Trading volume was exceptionally heavy at 28.1x the daily average, suggesting very strong buying interest.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Previous Earnings Reports
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Nov 06 | Q3 2025 earnings | Neutral | -13.6% | Q3 2025 results with lower revenue and ongoing CX-2051, CX-801 progress. |
| Aug 07 | Q2 2025 earnings | Positive | +11.9% | Q2 2025 update with positive CX-2051 data and $100M equity raise. |
| May 12 | Q1 2025 earnings | Positive | +129.4% | Q1 2025 results with strong revenue, cost cuts, and CX-2051 progress. |
| Mar 06 | 2024 results | Positive | +7.7% | 2024 financials highlighting CX-2051 advancement and higher collaboration revenue. |
| Nov 07 | Q3 2024 earnings | Positive | +9.0% | Q3 2024 update with revenue growth and early CX-2051 and CX-801 development. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Earnings and financial updates have historically triggered large moves (average 28.89%), mostly aligning with the generally positive tone around pipeline and cash runway.
Over recent earnings cycles, CytomX has paired financial updates with steady progress on Varseta-M (CX-2051) and CX-801. In 2024, revenue reached $138.1M with cash of $100.6M. Through 2025, Q1–Q3 updates highlighted strong interim CX-2051 data, expanding Phase 1 work, and a cash position bolstered by financings, extending runway toward Q2 2027. Price reactions to these earnings releases were often sizable in both directions, indicating that investors react strongly to each new combination of clinical and cash runway information.
Key Terms
epcam medical
probody medical
adc medical
bevacizumab medical
phase 1b/2 medical
interferon-alpha-2b medical
keytruda® medical
biomarker medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
- Announced Positive Data from Phase 1 Dose Expansion Study of varsetatug masetecan (“Varseta-M”) EpCAM PROBODY® ADC in Patients with Advanced Colorectal Cancer (CRC) -
- FDA interactions targeted for mid-year with goal to align on potential Varseta-M registrational trial design in late line CRC -
- Varseta-M Phase 1 study evaluating combination with bevacizumab initiated; Phase 1b/2 chemotherapy combination study to be initiated by the end of 2026 -
- Initial CX-801 PROBODY Interferon-alpha-2b Phase 1 combination data with KEYTRUDA® (pembrolizumab) in melanoma expected by the end of 2026 -
- Company to host conference call today at 8 a.m. ET / 5 a.m. PT -
SOUTH SAN FRANCISCO, Calif., March 16, 2026 (GLOBE NEWSWIRE) -- CytomX Therapeutics, Inc. (Nasdaq: CTMX), a leader in the field of masked, conditionally activated biologics, today announced 2025 financial results and provided a business update.
“Today’s encouraging Varseta-M Phase 1 update underscores the program’s intentional design and broad potential in CRC as well as other EpCAM-expressing indications. CytomX’s top priority in 2026 is to align with the FDA on a registrational path for Varseta-M in late-line CRC. We also plan to accelerate Varseta-M combination studies to benefit CRC patients in earlier lines of treatment,” said Sean McCarthy, D.Phil., chief executive officer and chairman of CytomX.
“Our continued and exciting progress with Varseta-M reinforces our leadership in the field of masking and CytomX’s ability to unlock true innovation. Our highly focused portfolio strategy is also illustrated by our second clinical program, CX-801. This masked version of Interferon-alpha-2b is being developed initially in advanced melanoma and, we believe, has the potential to become a new centerpiece of combination immunotherapy across multiple cancers. The CX-801 translational and biomarker data presented to date have been very encouraging, and we expect to share initial proof of concept data for the combination with KEYTRUDA® later this year.”
Pipeline Program Updates:
Varsetatug masetecan (EpCAM PROBODY Topo-1 ADC, CX-2051)
- Announced positive data update from Phase 1 dose expansion study of Varseta-M in patients with advanced colorectal cancer (CRC).
- The Company aims to align with the FDA in 2026 on a potential registrational study design for Varseta-M monotherapy in advanced CRC.
- Additional Phase 1 follow-up data are also expected to be presented at major medical meeting(s) in 2026.
- A Phase 1 Varseta-M combination study with bevacizumab in CRC has been initiated and a Phase 1b/2 study in combination with bevacizumab and chemotherapy is expected to start by the end of 2026.
- Initiation of Phase 1 expansion cohort(s) in additional indications is planned for 2H 2026.
CX-801 (PROBODY Interferon alpha-2b)
- The CX-801 Phase 1 study is progressing with a focus in advanced melanoma. The CX-801 monotherapy dose escalation portion of the study has reached the fourth dose level.
- CX-801 monotherapy has been well tolerated at dose levels exceeding the approved dose of unmasked IFNα2b.1
- In May 2025, Phase 1 dose escalation of CX-801 in combination with KEYTRUDA® (pembrolizumab) was initiated. Dose escalation of CX-801 in combination with KEYTRUDA® is currently enrolling the 2nd dose level.
- Biomarker data from the CX‑801 monotherapy study in advanced melanoma were presented at the 2025 Society for Immunotherapy of Cancer (SITC) Annual Meeting, reinforcing CX‑801’s mechanism of action and supporting the ongoing combination trial with KEYTRUDA®.
- Initial clinical data for CX-801 in combination with KEYTRUDA® in advanced melanoma is projected by the end of 2026.
KEYTRUDA® is a registered trademark of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA
Corporate and Financial:
- Financial:
- CytomX ended 2025 with
$137.1 million of cash, cash equivalents and investments with expected cash runway to the second quarter of 2027.
- CytomX ended 2025 with
- Research Pipeline and Collaborations:
- CytomX has research collaborations with Bristol Myers Squibb, Amgen, Regeneron, and Moderna. Multiple drug discovery programs continue across our research collaborations with a focus on bispecific immunotherapies, including T-cell engagers.
- In March 2026, Astellas chose to not advance the remaining preclinical research programs under the alliance resulting in a termination of the collaboration effective in the second quarter of 2026.
Full Year 2025 Financial Results:
Cash, cash equivalents and investments totaled
Total revenue was
In 2025, CytomX remained focused on controlling costs and efficiently progressing its pipeline programs. Total operating expense for 2025 was
Research and development expenses decreased by
General and administrative expenses increased by
About CytomX Therapeutics, Inc.
CytomX is a clinical-stage, oncology-focused biopharmaceutical company focused on developing novel conditionally activated, masked PROBODY® therapeutics designed to be localized to the tumor microenvironment. By pioneering a novel pipeline of localized biologics, powered by its PROBODY therapeutic platform, CytomX’s vision is to create safer, more effective therapies for the treatment of cancer. CytomX’s robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), cytokines and T-cell engagers. CytomX’s clinical-stage pipeline includes varsetatug masetecan (Varseta-M; CX-2051) and CX-801. Varseta-M is a masked, conditionally activated ADC armed with a topoisomerase-1 inhibitor payload and directed toward epithelial cell adhesion molecule (EpCAM). EpCAM is a highly expressed tumor antigen that has previously been undruggable due to expression on normal tissues. Varseta-M is designed to open a therapeutic window for this high potential target and is initially being developed for the treatment of metastatic colorectal cancer. Varseta-M was discovered in collaboration with ImmunoGen, now part of AbbVie. CX-801 is a masked interferon alpha-2b PROBODY® cytokine with broad potential applicability in traditionally immuno-oncology sensitive as well as insensitive (cold) tumors. CX-801 is initially being developed for the treatment of metastatic melanoma. CytomX has established strategic collaborations with multiple leaders in oncology, including Amgen, Bristol Myers Squibb, Regeneron and Moderna. For more information about CytomX and how it is working to make conditionally activated treatments the new standard-of-care in the fight against cancer, visit www.cytomx.com and follow us on LinkedIn and X (formerly Twitter).
CytomX Therapeutics Forward-Looking Statements
This press release includes forward-looking statements. Such forward-looking statements involve known and unknown risks, uncertainties and other important factors that are difficult to predict, may be beyond CytomX’s control, and may cause the actual results, performance, or achievements to be materially different from any future results, performance or achievements expressed or implied in such statements, including those related to the future potential of partnerships or collaboration agreements and projected cash runway. Accordingly, you should not rely on any of these forward-looking statements, including those relating to the potential benefits, safety and efficacy or progress of CytomX’s or any of its collaborative partners’ product candidates, including varsetatug masetecan (Varseta-M; CX-2051) and CX-801, the potential benefits or applications of CytomX’s PROBODY® therapeutic platform, CytomX's planned interactions with the U.S. Food and Drug Administration and the ability to align on a potential registrational study design and regulatory pathway for varsetatug masetecan, CytomX’s or its collaborative partners’ ability to develop and advance product candidates into and successfully complete clinical trials, including the ongoing and planned clinical trials of varsetatug masetecan and CX-801 and the timing of initial and ongoing data availability for CytomX’s clinical trials, including varsetatug masetecan and CX-801, and other development milestones. Risks and uncertainties that contribute to the uncertain nature of the forward-looking statements include: the unproven nature of CytomX’s novel PROBODY® therapeutic technology; uncertainties around the Company’s ability to raise sufficient funds to carry out its planned research and development; CytomX’s clinical trial product candidates are in the initial stages of clinical development and its other product candidates are currently in preclinical development, and the process by which preclinical and clinical development could potentially lead to an approved product is long and subject to significant risks and uncertainties, including the possibility that the results of preclinical research and early clinical trials, including initial varsetatug masetecan clinical trial results, may not be predictive of future results; the possibility that CytomX’s clinical trials will not be successful; the possibility that current preclinical research may not result in additional product candidates; CytomX’s dependence on the success of varsetatug masetecan and CX-801; CytomX’s reliance on third parties for the manufacture of the Company’s product candidates; possible regulatory developments in the United States and foreign countries, including China and the European Union; and the risk that we may incur higher costs than expected for research and development. Additional applicable risks and uncertainties include those relating to CytomX’s preclinical research and development, clinical development, and other risks identified under the heading "Risk Factors" included in CytomX’s Annual Report on Form 10-K filed with the SEC on March 16, 2026. The forward-looking statements contained in this press release are based on information currently available to CytomX and speak only as of the date on which they are made. CytomX does not undertake and specifically disclaims any obligation to update any forward-looking statements, whether as a result of any new information, future events, changed circumstances or otherwise.
PROBODY is a U.S. registered trademark of CytomX Therapeutics, Inc. All other trademarks are the properties of their respective owners.
Company Contact:
Chris Ogden
SVP, Chief Financial Officer
cogden@cytomx.com
Investor Contact:
Precision AQ
Stephanie Ascher
Stephanie.Ascher@precisionaq.com
Media Contact:
Precision AQ
Colleen Ketchum
Colleen.ketchum@precisionaq.com
| CYTOMX THERAPEUTICS, INC. BALANCE SHEETS (in thousands, except share and per share data) | ||||||||
| December 31, | December 31, | |||||||
| 2025 | 2024 | |||||||
| Assets | ||||||||
| Current assets | ||||||||
| Cash and cash equivalents | $ | 12,667 | $ | 38,052 | ||||
| Short-term investments | 124,385 | 62,571 | ||||||
| Accounts receivable | 2,013 | 3,103 | ||||||
| Prepaid expenses and other current assets | 4,856 | 3,579 | ||||||
| Total current assets | 143,921 | 107,305 | ||||||
| Property and equipment, net | 1,304 | 2,467 | ||||||
| Intangible assets, net | 438 | 583 | ||||||
| Goodwill | 949 | 949 | ||||||
| Restricted cash | 1,527 | 1,027 | ||||||
| Operating lease right-of-use asset | 3,396 | 8,136 | ||||||
| Other assets | 31 | 66 | ||||||
| Total assets | $ | 151,566 | $ | 120,533 | ||||
| Liabilities and Stockholders' Equity (Deficit) | ||||||||
| Current liabilities | ||||||||
| Accounts payable | $ | 1,301 | $ | 1,088 | ||||
| Accrued liabilities | 14,197 | 12,338 | ||||||
| Operating lease liabilities - short term | 4,240 | 5,145 | ||||||
| Deferred revenue, current portion | 26,877 | 67,201 | ||||||
| Total current liabilities | 46,615 | 85,772 | ||||||
| Deferred revenue, net of current portion | 1,590 | 26,862 | ||||||
| Operating lease liabilities - long term | — | 4,240 | ||||||
| Other long-term liabilities | 4,353 | 4,115 | ||||||
| Total liabilities | 52,558 | 120,989 | ||||||
| Commitments and contingencies | ||||||||
| Stockholders' equity (deficit) | ||||||||
| Convertible preferred stock | — | — | ||||||
| Common stock | 2 | 1 | ||||||
| Additional paid-in capital | 810,844 | 691,095 | ||||||
| Accumulated other comprehensive income | 111 | 27 | ||||||
| Accumulated deficit | (711,949 | ) | (691,579 | ) | ||||
| Total stockholders' equity (deficit) | 99,008 | (456 | ) | |||||
| Total liabilities and stockholders' equity (deficit) | $ | 151,566 | $ | 120,533 | ||||
| CYTOMX THERAPEUTICS, INC. STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS) (in thousands, except share and per share data) | ||||||||
| Year Ended December 31, | ||||||||
| 2025 | 2024 | |||||||
| Revenues | $ | 76,201 | $ | 138,103 | ||||
| Operating expenses: | ||||||||
| Research and development | 68,728 | 83,382 | ||||||
| General and administrative | 29,837 | 29,726 | ||||||
| Total operating expenses | 98,565 | 113,108 | ||||||
| Income (loss) from operations | (22,364 | ) | 24,995 | |||||
| Interest income | 5,206 | 7,136 | ||||||
| Other income (expense), net | 28 | (38 | ) | |||||
| Income (loss) before income taxes | (17,130 | ) | 32,093 | |||||
| Provision for income taxes | 238 | 224 | ||||||
| Net income (loss) | (17,368 | ) | 31,869 | |||||
| Deemed dividend on warrants | (3,002 | ) | — | |||||
| Net income (loss) attributable to common stockholders | $ | (20,370 | ) | $ | 31,869 | |||
| Other comprehensive income (loss): | ||||||||
| Unrealized gain (loss) on available-for-sale investments, net of tax | 84 | (68 | ) | |||||
| Total comprehensive income (loss) | $ | (17,284 | ) | $ | 31,801 | |||
| Net income (loss) per share: | ||||||||
| Basic | $ | (0.15 | ) | $ | 0.38 | |||
| Diluted | $ | (0.15 | ) | $ | 0.38 | |||
| Weighted average common shares used to compute net income (loss) per share | ||||||||
| Basic | 137,935,873 | 84,439,303 | ||||||
| Diluted | 137,935,873 | 84,745,116 | ||||||
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1 Merck & Co., Inc. (2018). Sylatron (peginterferon alfa-2b) prescribing information. U.S. Food and Drug Administration
