Pregnant Women Undertested for STIs, Finds Quest Diagnostics Health Trends® Study of Over 4 Million Pregnancies

Rhea-AI Summary

A Quest Diagnostics study published in the Journal of Lower Genital Tract Disease reveals significant gaps in STI testing for pregnant women. Analyzing over 4 million pregnancies, researchers found that 4% of women tested positive for chlamydia or gonorrhea in the first trimester. Alarmingly, 35% of these women didn't receive a follow-up negative test before delivery, suggesting potential untreated infections. The study highlights inconsistencies in guideline-based care, with 2% of initially negative patients later testing positive during pregnancy. Researchers recommend improving adherence to existing guidelines and updating recommendations for STI testing to enhance maternal and newborn health outcomes.

Positive

• Large-scale study covering 4,077,212 pregnancies across all 50 states and D.C.
• Identification of gaps in STI testing and treatment during pregnancy, potentially leading to improved guidelines
• Quest Diagnostics (DGX) positioning itself as a leader in women's health research and diagnostics

Negative

• Over 4% of pregnant women tested positive for chlamydia or gonorrhea in the first trimester
• 35.1% of chlamydia-positive and 36.9% of gonorrhea-positive women did not receive a follow-up negative test before delivery
• About 2% of initially negative patients later tested positive during pregnancy, indicating ongoing infection risk

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One in three women who tested positive for chlamydia or gonorrhea while pregnant were not retested before giving birth, despite potential to transmit infections to newborns

SECAUCUS, N.J., Aug. 12, 2024 /PRNewswire/ -- A new study by researchers from Quest Diagnostics (NYSE: DGX) and the University of Alabama suggests adherence to guideline-based laboratory testing and treatment of pregnant women for two of the most prevalent sexually transmitted infections (STIs) is suboptimal in the United States, with potentially dire effects on maternal and newborn health.

The study, titled Chlamydia and gonorrhea testing in pregnancy: Time to improve adherence and update recommendations, was published in the peer reviewed Journal of Lower Genital Tract Disease, the official journal of the American Society for Colposcopy and Cervical Pathology. It is based on deidentified results of lab tests performed by Quest in all 50 states and the District of Columbia for 4,077,212 pregnancies.

The findings suggest gaps in guideline-based care, intended to reduce the risk of infection and medical complications. Untreated chlamydia and gonorrhea can raise risks of infertility and pelvic inflammatory disease in women. The risk of transmission during birth is approximately 50%, raising the potential for newborns to develop infections of the eye (conjunctivitis), lungs (pneumonia) and other health problems.

"Our study adds to a troubling body of evidence highlighting inconsistent quality in maternal and child healthcare in the U.S.," said Damian P. Alagia, MD, co-author of the study and Medical Director of Women's Health at Quest Diagnostics. "Our analysis shows that improved adherence to existing recommendations, harmonization of guidelines across agencies, and even updated recommendations for STI testing will be critical to ensuring the mothers and babies in the United States receive medically appropriate testing and treatment."

Key findings:

• Over 4% of women who received guideline-based screening for chlamydia or gonorrhea in pregnancy during the first trimester received a positive result for one or both infections.
• More than one in three of these women (35.1% chlamydia; 36.9% gonorrhea) did not receive a follow up negative test before delivery, suggesting they may not have been treated and cured (or were treated, cured but then reinfected) before birth.
• About 2% of patients who received a negative test result for chlamydia or gonorrhea early in pregnancy later received a positive result, suggesting "an ongoing risk of infection during pregnancy". Of these, about one in two were still positive prior to delivery. (53.0% chlamydia and 49.3% gonorrhea).

The authors believe reinfections (or ineffectively treated initial infections) may result in an increased number of deliveries while women are positive with one or more STIs, which can impact both maternal and newborn health.

The authors conclude current guidelines are inconsistent and they provide several recommendations for improvements. For instance, the CDC recommends women be retested for cure at 4 weeks of pregnancy while the USPSTF recommends retesting before 3 weeks. Current guidelines also do not recommend screening women after the age of 25 years unless there are risk factors (such as multiple partners), based on a study from 1998 when women married at younger ages than today. Guidelines recommend that all women under the age of 25 be screened, regardless of perceived risk.

The study's strengths include its large size, national representation, and use of objective laboratory data. Its limitation is the lack of clinical follow-up information for the positive cases, as testing was limited to one national clinical laboratory. While the authors did not evaluate other STIs, such as syphilis, they caution these patterns of irregular adherence to guideline-based testing in maternal care may extend to other conditions.

According to the Centers for Disease Control and Prevention (CDC), cases of sexually transmitted disease are at an all-time high, with more than 2.5 million cases of syphilis, gonorrhea, and chlamydia reported in the United States in 2022.

About Quest Diagnostics
Quest Diagnostics works across the healthcare ecosystem to create a healthier world, one life at a time. We provide diagnostic insights from the results of our laboratory testing to empower people, physicians and organizations to take action to improve health outcomes. Derived from one of the world's largest databases of de-identifiable clinical lab results, Quest's diagnostic insights reveal new avenues to identify and treat disease, inspire healthy behaviors and improve healthcare management. Quest Diagnostics annually serves one in three adult Americans and half the physicians and hospitals in the United States, and our nearly 50,000 employees understand that, in the right hands and with the right context, our diagnostic insights can inspire actions that transform lives and create a healthier world. www.QuestDiagnostics.com.

For more Quest Diagnostics Health Trends® reports, visit www.Newsroom.QuestDiagnostics.com/Health-Trends.

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SOURCE Quest Diagnostics

FAQ

What percentage of pregnant women tested positive for STIs in the Quest Diagnostics study?

Over 4% of women who received guideline-based screening for chlamydia or gonorrhea in pregnancy during the first trimester tested positive for one or both infections.

How many pregnancies were analyzed in the Quest Diagnostics (DGX) STI study?

The study analyzed deidentified results of lab tests performed by Quest Diagnostics for 4,077,212 pregnancies across all 50 states and the District of Columbia.

What percentage of STI-positive pregnant women did not receive a follow-up negative test before delivery?

More than one in three women (35.1% for chlamydia and 36.9% for gonorrhea) who tested positive did not receive a follow-up negative test before delivery.

What are the potential risks of untreated STIs during pregnancy according to the Quest Diagnostics study?

Untreated chlamydia and gonorrhea can raise risks of infertility and pelvic inflammatory disease in women. There's also a 50% risk of transmission during birth, potentially causing eye infections, pneumonia, and other health problems in newborns.