Ginkgo Bioworks integrates Callisto for difficult-to-automate NGS processes in their high-throughput lab

Rhea-AI Summary

Ginkgo Bioworks (NYSE: DNA) has integrated the Callisto™ Sample Prep System into their routine Illumina sequencing workflow. The system, developed by Volta Labs, addresses the automation challenges in DNA clean-up processes, particularly for high-throughput labs handling thousands of samples.

The Callisto system features an App Store concept that enables access to multiple sequencing technologies and chemistries on a single platform, helping maintain low operating costs. A notable addition is the Size Selection app, which allows short-read labs using Illumina, Element Biosciences, and Ultima Genomics platforms to purify and select optimal fragment sizes for sequencing.

The system's advanced electrowetting, magnetic, and acoustic capabilities, along with its proprietary VoltaNode™ technology, enable precise liquid separation, efficient DNA elution from beads, and flexible batch processing.

Positive

• Integration of Callisto system expected to improve operational efficiency in DNA sequencing workflow
• App Store concept helps maintain low operating costs through multiple sequencing technologies access
• System provides complete walk-away automation capability for high-throughput processing

Negative

• None.

BOSTON, Feb. 21, 2025 /PRNewswire/ -- Volta Labs, a leading genomics applications company, and Ginkgo Bioworks, (NYSE: DNA), which is building a leading platform for cell programming and biosecurity, today announced the integration of the Callisto™ Sample Prep System at Ginkgo Bioworks as part of the routine Illumina sequencing workflow.

"I like the Apps and the App Store concept on Callisto. It allows us to keep our operating costs low and access multiple sequencing technologies and chemistries on the same platform," said Alex Plocik, Senior Director of Genomics at Ginkgo Bioworks. "In our short-read sequencing workflow, we often pool thousands of individual samples into tens of sample pools for bead clean ups with varying batch size from day to day. The Callisto system is perfect for this use case while providing a complete walk away experience." 

"Ginkgo has been a valued partner for Volta Labs since inception," said Udayan Umapathi, founder and CEO of Volta Labs. "Their team has played an instrumental role in refining our solution for high throughput labs. I am excited about the short-term integration of Callisto into their Illumina workflows and the long-term potential to expand into many applications."

Size selection is one of the newest apps to be released in the Volta Apps menu. This app allows all short-read labs performing sequencing on Illumina, Element Biosciences and Ultima Genomics platforms to purify and select optimal fragment sizes for sequencing. Despite significant advancements in sequencing, something as primitive as DNA clean-up is challenging to automate on traditional liquid handling technologies. Callisto's advanced electrowetting, magnetic and acoustic capabilities enable very precise and clean separation of liquids, efficient elution of DNA from beads, and batch-level flexibility enabled by proprietary VoltaNode™ technology. Kits are now available to order for all customers interested in using the Double-Sided Size Selection app on Callisto.

About Volta Labs
Volta Labs is a genomics applications company that has developed a cutting-edge digital fluidics platform to maximize performance and scalability of sample preparation in genomics while providing unparalleled consistency. Volta is transforming the way biological research and analyses are performed, allowing scientists to focus on what they do best -- pushing the boundaries of biology.

About Ginkgo Bioworks
Ginkgo Bioworks is the leading horizontal platform for cell programming, providing flexible, end-to-end services that solve challenges for organizations across diverse markets, from food and agriculture to pharmaceuticals to industrial and specialty chemicals. Ginkgo Biosecurity is building and deploying the next-generation infrastructure and technologies that global leaders need to predict, detect, and respond to a wide variety of biological threats. For more information, visit ginkgobioworks.com and ginkgobiosecurity.com, read our blog, or follow us on social media channels such as X (@Ginkgo and @Ginkgo_Biosec), Instagram (@GinkgoBioworks), Threads (@GinkgoBioworks) or LinkedIn.

Media Contacts:
Volta Labs
kmiller@voltalabs.co

Ginkgo Bioworks
press@ginkgobioworks.com

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SOURCE Volta Labs Inc.

FAQ

What is the impact of Callisto integration on Ginkgo Bioworks (DNA) operations?

The Callisto integration enables Ginkgo Bioworks to automate difficult DNA clean-up processes, handle thousands of samples efficiently, and maintain low operating costs through access to multiple sequencing technologies on a single platform.

How does the Callisto Size Selection app benefit DNA stock's sequencing capabilities?

The Size Selection app allows Ginkgo Bioworks to purify and select optimal fragment sizes for sequencing across multiple platforms including Illumina, Element Biosciences, and Ultima Genomics, enhancing their sequencing capabilities.

What technological advantages does the Callisto system bring to Ginkgo Bioworks (DNA)?

The system provides advanced electrowetting, magnetic and acoustic capabilities, enabling precise liquid separation, efficient DNA elution from beads, and flexible batch processing through VoltaNode™ technology.

How does the Callisto integration affect DNA's operating costs?

The Callisto system's App Store concept helps Ginkgo Bioworks maintain low operating costs by providing access to multiple sequencing technologies and chemistries on a single platform.