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Alpha Tau Medical Ltd. develops Alpha DaRT, an alpha-radiation cancer therapy designed for localized treatment of solid tumors through intratumoral delivery of radium-224 impregnated sources. News about the company centers on clinical programs in recurrent cutaneous squamous cell carcinoma, pancreatic cancer, recurrent glioblastoma, prostate cancer, and head and neck cancer, along with presentations of study data at oncology and gastroenterology meetings.
Recurring updates also cover regulatory activity for Alpha DaRT, including FDA pre-market approval materials, Breakthrough Device Designation references, and Japanese marketing approval for unresectable locally advanced or locally recurrent head and neck cancer. Other company news addresses financial results, corporate updates, manufacturing preparation, and investor conference presentations.
Alpha Tau announced the publication of long-term safety and efficacy data for its Alpha DaRT™ cancer therapy in the journal Cancers. The pooled analysis included 81 patients with hard-to-treat skin, head and neck, and oral cavity cancers from four international clinical trials. The results demonstrated an overall response rate of 99%, with a complete response rate of 89% and a 10% partial response rate. No moderate or severe long-term toxicities were observed, and the two-year local recurrence-free survival was estimated at 77%. Follow-up spanned up to 51 months, with a median of 14 months. The study suggests that Alpha DaRT may offer long-term disease control with minimal side effects for difficult-to-treat cancers.
Alpha Tau Medical, a leader in alpha-radiation cancer therapy, announced its participation in the Jefferies Global Healthcare Conference on June 5, 2024. Their CFO, Raphi Levy, will present a corporate overview and update at the event scheduled from 1:30 to 1:55 PM EST in New York. Levy will also be available for one-on-one meetings with investors during the conference. Attendees are encouraged to contact their Jefferies representative to schedule a session.
Alpha Tau Medical reported its Q1 2024 financials and provided a corporate update. The company presented preclinical data showcasing an abscopal immune effect in pancreatic murine tumor models at ESTRO 2024. The first patient in a liver metastases study was treated at McGill University Health Center, with recruitment ongoing for multiple trials. Financially, the company recorded R&D expenses of $6.4 million, marketing expenses of $0.5 million, and G&A expenses of $1.4 million, resulting in a net loss of $8.0 million. Alpha Tau holds $80.7 million in cash, projected to fund operations for at least two years.
Alpha Tau Medical announced the treatment of the first patient with liver cancer metastases using their innovative alpha-radiation cancer therapy, Alpha DaRT. The feasibility and safety study is being conducted at McGill University Health Center in Montreal, Canada. The trial aims to recruit up to 10 patients for a two-staged hepatectomy to resect liver metastases of colorectal cancer. The study will assess the feasibility and safety of delivering Alpha DaRT sources into the liver metastases, as well as its efficacy in terms of radiological and pathological response. CEO Uzi Sofer expressed optimism about the trial's potential to provide new therapeutic options for patients with liver metastases and other challenging cancers.
Alpha Tau Medical presented new preclinical data at the 2024 ESTRO Congress, showcasing the abscopal immune effect of Alpha DaRT in pancreatic murine tumor models. The data revealed a significant reduction in distant tumor growth rate, indicating potential benefits for future clinical trials and patient outcomes. CEO Uzi Sofer highlighted the promising results, emphasizing the therapy's potential in combination with immunotherapy.
Alpha Tau Medical announced that CFO Raphi Levy will present at investor conferences in May 2024. The company, known for its alpha-radiation cancer therapy Alpha DaRT™, will participate in events like Guggenheim Securities Radiopharmaceuticals Day and H.C. Wainwright BioConnect Investor Conference.
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