Welcome to our dedicated page for Precision Biosciences news (Ticker: DTIL), a resource for investors and traders seeking the latest updates and insights on Precision Biosciences stock.
News and updates for Precision BioSciences, Inc. (Nasdaq: DTIL) center on its progress as a clinical stage gene editing company using the ARCUS platform to develop in vivo therapies for serious genetic and infectious diseases. Company announcements frequently highlight developments in its pipeline, clinical trial milestones, scientific publications, and capital markets activity.
A major focus of Precision’s news flow is PBGENE-HBV, the company’s wholly owned in vivo gene editing program for chronic hepatitis B. Updates include data from the global ELIMINATE-B trial, covering safety, dose-dependent antiviral activity, reductions in hepatitis B surface antigen (HBsAg), and biopsy evidence of ARCUS-mediated viral DNA editing. Press releases also describe regulatory designations such as Breakthrough Therapy status and the expansion of clinical trial sites across multiple countries.
Another recurring theme is PBGENE-DMD, a muscle-targeted excision program for Duchenne muscular dystrophy. News items discuss preclinical data on dystrophin restoration and functional muscle improvement, preparations for investigational new drug (IND) submissions, and plans for Phase 1/2 clinical studies in DMD patients with mutations in exons 45–55 of the dystrophin gene.
Investors can also find updates on partnered in vivo programs, such as ECUR-506 for neonatal onset OTC deficiency developed by iECURE using a licensed ARCUS nuclease, along with regulatory milestones like RMAT designation. Additional coverage includes progress in non-core ex vivo programs such as azer-cel, an allogeneic CAR T therapy being advanced by partners for lymphoma and autoimmune diseases.
Financial and corporate news, including quarterly results, equity offerings, and strategic priorities, round out the DTIL news stream. For those tracking gene editing, hepatitis B, DMD, and ARCUS-based therapies, this page provides an organized view of Precision BioSciences’ latest disclosures and clinical developments over time.
Precision BioSciences (DTIL) has accelerated its clinical development, expecting three new drug applications within three years targeting familial hypercholesterolemia, primary hyperoxaluria type 1, and chronic hepatitis B. A licensing agreement with iECURE aims to advance PBGENE-PCSK9 through Phase 1 trials, while preclinical data showcases their ARCUS genome editing platform's precision. The company has approximately $167 million in cash, sufficient to fund operations into 2023.
Precision BioSciences has partnered with iECURE to license its PCSK9-directed ARCUS nuclease, aiming to advance the PBGENE-PCSK9 candidate for treating familial hypercholesterolemia into Phase 1 clinical trials as early as 2022. Precision retains rights to all indications related to PBGENE-PCSK9 while iECURE gains access to develop therapies for four rare genetic liver diseases. Additionally, Precision will secure equity in iECURE and potential milestone and royalty payments from product sales.
Precision BioSciences (Nasdaq: DTIL) has secured an exclusive license from Tiziana Life Sciences (Nasdaq: TLSA) to utilize foralumab, a human anti-CD3 monoclonal antibody, as a lymphodepletion agent in its allogeneic CAR T therapy development. The collaboration aims to enhance the therapeutic effectiveness of CAR T cells by improving their tolerance and long-term persistence. Precision will oversee the development and commercialization of foralumab, providing Tiziana with upfront, milestone, and royalty payments.
Precision BioSciences, Inc. (NASDAQ: DTIL) announced its inaugural R&D event on September 9, 2021, at 8:00 am ET, focusing on in vivo gene editing. The event will feature management presentations and guest speakers, highlighting the company's development strategy and progress in in vivo gene editing projects. Attendees can expect insights on the ARCUS gene editing platform, pre-clinical data, and collaboration updates. Registration for the live webcast is available on the company’s investor website, with a replay accessible for one year post-event.
Precision BioSciences (Nasdaq: DTIL) reported strong financial results for Q2 ended June 30, 2021, with total revenues of $68.8 million, a significant increase from $1.1 million in Q2 2020. This surge was driven primarily by a $62.0 million revenue boost from the Servier Agreement. The company also noted a net income of $21.7 million compared to a net loss of $32.7 million in the prior year. R&D expenses rose to $37.2 million, reflecting ongoing investments in its ARCUS-edited CAR T programs. Additionally, Precision continues to advance its gene editing initiatives and has approximately $173.9 million in cash, sufficient to fund operations into 2023.
Precision BioSciences, Inc. (Nasdaq: DTIL) is set to release its financial results for Q2 2021 and provide a business update on August 12, 2021. The company focuses on developing allogeneic CAR T therapies and in vivo gene correction therapies through its proprietary ARCUS® genome editing platform. Designed for therapeutic safety and effectiveness, ARCUS underpins Precision's pipeline, which includes various CAR T immunotherapy candidates and in vivo gene correction therapies aimed at tackling genetic and infectious diseases.
Precision BioSciences, Inc. (Nasdaq: DTIL) has successfully dosed its first patient in a Phase 1 clinical trial of PBCAR19B, a promising allogeneic CAR T therapy for relapsed/refractory non-Hodgkin lymphoma (NHL). This marks the company's fourth CAR T program, showcasing the versatility of its ARCUS genome editing platform. The trial aims to determine the maximum tolerated dose and assess safety, with an initial dose level starting at 2.7 × 108 CAR T cells. Precision believes its immune-evading stealth cell technology will enhance treatment efficacy without prolonged immunosuppression.
Precision BioSciences (DTIL) and SpringWorks Therapeutics (SWTX) announced that the first patient has been dosed in their Phase 1/2a trial combining PBCAR269A, an allogeneic CAR T cell therapy targeting BCMA, with nirogacestat, a gamma secretase inhibitor, for treating relapsed/refractory multiple myeloma.
Precision is also gearing up to share interim results from monotherapy studies and plans to progress PBCAR269B into clinical trials in 2022, highlighting their commitment to developing innovative therapies.
Precision BioSciences Inc. (Nasdaq: DTIL) has made notable advancements in allogeneic CAR T therapies for relapsed/refractory non-Hodgkin lymphoma (NHL). Interim data from the Phase 1/2a study of PBCAR0191 reveal a 75% overall response rate and a 50% complete response rate among 12 patients treated with enhanced lymphodepletion (eLD). Additionally, preclinical results suggest that the new PBCAR19B stealth cell may effectively evade immune rejection. The FDA has accepted the investigational new drug application for PBCAR19B, which is now open for enrollment.
Precision BioSciences, Inc. (Nasdaq: DTIL) has announced the publication of a new paper in Nature Communications detailing preclinical results using its ARCUS nuclease to target and reduce mutant mitochondrial DNA (mtDNA) in vivo. The study led by Dr. Carlos T. Moraes demonstrated effective shifts in mtDNA heteroplasmy and notable safety in mouse models. MitoARCUS achieved up to 60% heteroplasmic shifts in vitro and showed no off-target editing in vivo. This innovative approach to gene editing may hold significant therapeutic promise for mitochondrial diseases, with further research anticipated.
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