Emergent BioSolutions and PANTHER Announce Agreement to Support the Continuation of the Africa CDC-led MpOx Study in Africa

Emergent BioSolutions (NYSE: EBS) agreed to provide additional financial support to continue the Africa CDC-led MpOx Study in Africa (MOSA), a double-blind, platform-adaptive clinical trial launched in 2024 to evaluate treatments for mpox.

Rhea-AI Summary

Emergent BioSolutions (NYSE: EBS) agreed to provide additional financial support to continue the Africa CDC-led MpOx Study in Africa (MOSA), a double-blind, platform-adaptive clinical trial launched in 2024 to evaluate treatments for mpox.

An independent data and safety monitoring board completed an initial safety review in December 2025 after 50 patients were randomized and recommended continuation with no safety concerns identified. Africa CDC and PANTHER plan to extend MOSA to additional countries, including a site in Uganda, and enroll more patients toward the next milestone.

The release notes there is currently no dedicated antiviral therapy for mpox and cites Africa CDC case totals of 61,383 confirmed cases and 296 deaths across 32 countries since 2024.

Positive

• DSMB recommended trial continuation after initial 50 patients, no safety concerns
• Emergent (NYSE: EBS) committed additional financial support to sustain MOSA
• MOSA to expand to new countries, including a planned site in Uganda

Negative

• None.

Argus Jan 8 session

-3.88% close to close Open Argus

Details

News Market Reaction – EBS

On Jan 8, the day this news came out, EBS closed 3.88% below the previous close.

Data tracked by StockTitan Argus for the Jan 8 session.

Key Figures

Initial randomized patients: 50 patients MOSA launch year: 2024 Reported mpox cases: 61,383 confirmed cases +2 more

Initial randomized patients

50 patients

First safety review of MOSA trial in Dec 2025

MOSA launch year

2024

Start of double-blind, platform-adaptive mpox trial

Reported mpox cases

61,383 confirmed cases

Africa-wide mpox cases since beginning of 2024

Reported mpox deaths

296 deaths

Africa-wide mpox deaths since beginning of 2024

Countries affected

32 countries

African countries with confirmed mpox cases

Historical Context

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1. Dec 12

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2. Nov 18

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3. Nov 12

   Board retirement

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4. Oct 29

   Earnings results

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   Q3 2025 beat guidance and raised full-year outlook but shares dipped slightly.

5. Oct 28

   Biothreat survey

   24h Move

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   Released survey showing heightened concern about biological threats and preparedness.

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Key Terms

double-blind, platform-adaptive, clinical trial, data and safety monitoring board (DSMB), +1 more

5 terms

double-blind medical

"MOSA is a double-blind, platform-adaptive clinical trial designed..."

A double-blind process means that neither the people conducting an activity nor the people involved know certain key details, such as who is receiving a treatment or a placebo. This approach helps prevent bias from influencing the results, making the outcome more trustworthy. For investors, it ensures that decisions or judgments are based on unbiased information rather than preconceived opinions or expectations.

platform-adaptive medical

"MOSA is a double-blind, platform-adaptive clinical trial designed..."

Software, services, or products described as platform-adaptive can change their behavior or appearance to work well across different devices, operating systems, or distribution channels without requiring separate versions. For investors this matters because a platform-adaptive offering is like a universal charger or a bilingual employee: it reaches more customers with lower development and maintenance cost, speeds adoption across markets, and reduces the risk that a single platform’s problems will hurt revenue.

clinical trial medical

"MOSA is a double-blind, platform-adaptive clinical trial designed..."

A clinical trial is a carefully controlled study in which a new medicine, medical device, or treatment is tested on people to see if it is safe and effective. For investors it matters because trial results determine whether a product can win regulatory approval and reach patients, much like a road test decides if a new car can be sold; positive or negative results can sharply change a company’s prospects and stock value.

data and safety monitoring board (DSMB) medical

"An independent data and safety monitoring board (DSMB) completed its initial review..."

An independent panel of medical, statistical and ethical experts who regularly review the safety and results coming from a clinical trial and can recommend changes, pauses or early stop if risks or benefits become clear. Think of it as an impartial referee watching a game to protect participants and ensure the score is reliable; its decisions can materially affect trial timing, regulatory approval prospects and therefore investor value.

clade medical

"Africa has both major mpox clades, Clade I... and Clade II..."

A clade is a group of organisms or virus strains that all descend from a common ancestor, identified by shared genetic characteristics. For investors, clades matter because different clades can behave differently—for example, spreading faster, resisting treatments, or changing diagnostic accuracy—so knowing which clade is circulating is like knowing which model of car is on the road when deciding maintenance or insurance risk.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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GAITHERSBURG, Md. and PARIS and ADDIS ABABA, Ethiopia, Jan. 08, 2026 (GLOBE NEWSWIRE) -- Today Emergent BioSolutions (NYSE: EBS) announced a collaboration agreement with PANTHER to provide additional financial support to continue progressing the Africa CDC-led ‘MpOx Study in Africa’ (MOSA). This initiative aims to advance research into effective treatments for patients diagnosed with mpox, a virus for which there is currently no dedicated antiviral therapy. Launched in 2024, MOSA is a double-blind, platform-adaptive clinical trial designed to evaluate potential treatment options for mpox across multiple African countries. The study initially received funding from the European Union and Africa CDC.

An independent data and safety monitoring board (DSMB) completed its initial review of MOSA safety data in December 2025 after the first 50 patients were randomised and recommended continuation of the trial, with no safety concerns identified.

“We applaud Africa CDC, the Democratic Republic of Congo investigators, and PANTHER for their efforts in reaching this important milestone and are proud to support the advancement of the MOSA trial,” said Simon Lowry, M.D., chief medical officer, head of research and development, Emergent. “Emergent is committed to collaborating with research partners around the world to study medications that address global health threats.”

As the study continues, Africa CDC and PANTHER intend to extend the study to new countries, including a site in Uganda, and enroll patients to reach the next milestone.

“This study represents a critical step in generating evidence to inform mpox treatment and strengthen Africa’s capacity to respond to emerging health threats," said Africa CDC Director General, Dr Jean Kaseya. "Africa CDC will continue working closely with partners whose collaboration and support are essential in advancing research and improving preparedness across the continent.”

Since the beginning of 2024, the continent has reported more than 61,383 confirmed cases and 296 deaths across 32 countries, according to Africa CDC. Africa has both major mpox clades, Clade I, which is endemic to Central Africa and causes more severe illness, and Clade II, which is more prevalent in West Africa; recent outbreaks have featured subclades like Clade Ia, Ib, and Clade IIa and IIb.

About Emergent BioSolutions
At Emergent, our mission is to protect and save lives. For over 25 years, we’ve been at work preparing those entrusted with protecting public health. We deliver protective and life-saving solutions for health threats like smallpox, mpox, botulism, Ebola, anthrax, and opioid overdose emergencies. To learn more about how we help prepare communities around the world for today’s health challenges and tomorrow’s threats, visit our website and follow us on LinkedIn, X, Instagram, Apple Podcasts and Spotify. 

About the Pandemic Preparedness Platform for Health and Emerging Infections Response (PANTHER)

PANTHER is an African-led pandemic preparedness platform for health and emerging infection response. Bringing together leading African and global researchers and public health teams, it aims to create regional hubs and clinical research platforms to support preparedness and rapid response to emerging infectious diseases globally, particularly in Africa. For more information, visit https://pantherhealth.org.

PANTHER is sponsoring MOSA as part of the MPX-RESPONSE Project that has received funding from the European Union’s Horizon Europe Research and Innovation programme under grant agreement 101115188.

About Africa Centres for Disease Control and Prevention (Africa CDC)

The Africa Centres for Disease Control and Prevention (Africa CDC) is a public health agency of the African Union. It is autonomous and supports member states in strengthening health systems. It also helps improve disease surveillance, emergency response, and disease control. Learn more at: Africa CDC and connect with us on LinkedIn, Twitter, Facebook and YouTube.

Investor Contact:
Richard S. Lindahl
Executive Vice President, CFO, Emergent
lindahlr@ebsi.com

Media Contacts:
Assal Hellmer
Vice President, Communications, Emergent
mediarelations@ebsi.com

Jessica Ilunga
Communications Officer, PANTHER
media@pantherhealth.org  

Margaret Edwin
Director of Communication and Public Information Africa CDC
EdwinM@africacdc.org

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What did Emergent (EBS) announce about the MpOx Study in Africa on January 8, 2026?

Emergent announced it will provide additional financial support to continue the Africa CDC-led MOSA trial evaluating mpox treatments.

What was the outcome of the MOSA DSMB review mentioned by Emergent (EBS)?

The independent DSMB completed an initial review after 50 randomized patients in December 2025 and recommended continuation with no safety concerns.

Will the MOSA trial supported by Emergent (EBS) expand to more countries?

Yes; Africa CDC and PANTHER intend to extend MOSA to additional countries, including a planned site in Uganda.

Does the press release state there is an approved antiviral for mpox?

No; the announcement notes there is currently no dedicated antiviral therapy for mpox.

How large has the mpox burden been in Africa according to the announcement?

The release cites 61,383 confirmed cases and 296 deaths across 32 countries since 2024, per Africa CDC.