Welcome to our dedicated page for Erasca news (Ticker: ERAS), a resource for investors and traders seeking the latest updates and insights on Erasca stock.
Erasca, Inc. (ERAS) is a clinical-stage precision oncology company pioneering therapies for cancers driven by RAS/MAPK pathway abnormalities. This page serves as the definitive source for official updates spanning clinical developments, regulatory milestones, and strategic initiatives.
Investors and researchers will find curated news about Erasca’s pipeline candidates including pan-RAF inhibitor naporafenib, ERK1/2 inhibitor ERAS-007, and emerging preclinical assets. Our repository includes trial progress reports, partnership announcements, and scientific presentations – all essential for tracking advancements in targeted cancer therapies.
Regular updates cover key areas: clinical trial phase transitions, FDA designations, collaborative research agreements, and preclinical discoveries. Each release is vetted for accuracy, providing reliable insights into Erasca’s mission to disrupt oncogenic signaling pathways.
Bookmark this page for streamlined access to ERAS news. Combine our updates with SEC filings and scientific publications for comprehensive analysis of this innovative oncology biotech.
Erasca, Inc. (Nasdaq: ERAS) has announced presentations at the American Society of Clinical Oncology (ASCO) Annual Meeting, scheduled for June 2-6, 2023, in Chicago. The posters will detail preliminary Phase 1b combination data for ERAS-007, a potential best-in-class ERK1/2 inhibitor, in patients with gastrointestinal malignancies. Key presentations include:
- Abstract 3557: Data from ERAS-007 combined with encorafenib and cetuximab in patients with metastatic BRAF V600E mutated colorectal cancer.
- Abstract 3558: Data from ERAS-007 combined with palbociclib in patients with KRAS/NRAS mutated colorectal cancer or KRAS mutated pancreatic ductal adenocarcinoma.
These studies reflect Erasca's commitment to advancing therapies targeting the RAS/MAPK pathway.
Erasca, Inc. (ERAS) recently published preliminary results in the Journal of Clinical Oncology from a Phase 1b study assessing naporafenib and trametinib for NRAS-mutant melanoma. The study reported a promising 47% overall response rate (ORR) and a median progression-free survival (mPFS) of 5.5 months using a preferred dosing regimen. This combination is significant as NRAS mutations affect about 20% of melanoma patients, with no currently approved targeted therapies. Given its higher efficacy compared to standard chemotherapy, which shows an ORR of only 7% and mPFS of 1.5 months, Erasca plans to initiate a pivotal Phase 3 trial (SEACRAFT-2) in H1 2024. The study reinforces the potential of this combination therapy in improving outcomes for patients with NRASm melanoma.
Erasca (Nasdaq: ERAS) announced promising initial results from the Phase 1b FLAGSHP-1 study for its SHP2 inhibitor ERAS-601 combined with cetuximab (ERBITUX) in patients with advanced solid tumors. The combination therapy showed favorable pharmacokinetics, with no significant drug-drug interactions and primarily low-grade adverse events (AEs). The maximum tolerated dose was established at 40 mg BID with a dosing schedule of three weeks on followed by one week off. The company plans to explore efficacy in HPV-negative head and neck squamous cell carcinoma (HNSCC), an area of high unmet medical need, with dose expansion data expected in the first half of 2024. The results support the potential of ERAS-601 as a backbone therapy, aiming to delay therapeutic resistance in cancer treatment.
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