Erasca, Inc. Stock Price, News & Analysis

Erasca, a clinical-stage precision oncology company, reported promising Phase 1/1b data for its ERK1/2 inhibitor ERAS-007 and SHP2 inhibitor ERAS-601 in treating RAS/MAPK-altered solid tumors. The retrospective analysis revealed that 23% of patients with non-CRC solid tumors and 44% of those with BRAF-driven tumors responded to these agents. Both drugs demonstrated favorable safety profiles, supporting their combination in upcoming trials. The initiation of the ERAS-007 plus ERAS-601 MAPKlamp trial is anticipated in the first half of 2023.

Erasca, Inc. (Nasdaq: ERAS) will host a virtual research and development day on September 7, 2022, featuring key opinion leader Dr. David Hong from MD Anderson Cancer Center. The event will present preliminary clinical data for Erasca's lead candidates, the ERK1/2 inhibitor ERAS-007 and the SHP2 inhibitor ERAS-601, targeting advanced solid tumors influenced by the RAS/MAPK pathway. Participants can register online for the event, which will include a live Q&A session.

Erasca, Inc. (Nasdaq: ERAS) has entered a five-year collaboration with The University of Texas MD Anderson Cancer Center to evaluate multiple agents targeting the RAS/MAPK pathway. The partnership's initial focus is on ERAS-007, an ERK1/2 inhibitor, and ERAS-601, a SHP2 inhibitor. These will be combined in the first MAPKlamp approach. Ongoing clinical trials of these agents will target various cancers, including non-small cell lung cancer and gastrointestinal malignancies. The collaboration aims to enhance the clinical development of Erasca's pipeline in addressing significant cancer treatment challenges.

Erasca, Inc. (Nasdaq: ERAS) reported Q2 2022 financial results, showcasing a cash reserve of $391 million. The company is advancing its clinical programs, expecting initial data for ERAS-007 and ERAS-601 by H2 2022. Notable collaborations include partnerships with Eli Lilly and Harvard Medical School to enhance ERAS-007 and ERAS-601's potential. R&D expenses rose to $27.5 million, driven by clinical trials, while G&A expenses increased to $8.4 million. The net loss for the quarter stands at $35.6 million, or $(0.30) per share.

Erasca has entered a clinical trial collaboration with Eli Lilly to evaluate ERAS-601, a selective SHP2 inhibitor, in the FLAGSHP-1 trial. This Phase 1/1b trial will assess ERAS-601 combined with Lilly's cetuximab for treating triple wildtype metastatic colorectal cancer and HPV-negative advanced head and neck squamous cell carcinoma. Lilly will provide cetuximab at no cost. The collaboration aims to enhance treatment responses and delay resistance onset in RAS/MAPK driven cancers, addressing significant market needs given the rising case numbers of these malignancies.

Erasca, Inc. (Nasdaq: ERAS), a clinical-stage precision oncology company focused on therapies for RAS/MAPK pathway-driven cancers, will present at the 2022 Jefferies Healthcare Conference on June 10, 2022, at 8:00 AM ET in New York. CEO Jonathan E. Lim and CFO David M. Chacko will represent the company and participate in one-on-one investor meetings. A live webcast and an archived replay of the presentation will be available online, continuing until September 10, 2022. Erasca’s mission is to erase cancer through innovative therapies targeting the RAS/MAPK pathway.

Erasca, Inc. (NASDAQ: ERAS) announced a Phase 1b clinical trial for ERAS-007, an ERK1/2 inhibitor, in combination with a KRAS G12C inhibitor, targeting KRAS G12C-driven non-small cell lung cancer (NSCLC) and colorectal cancer (CRC). This trial aims to address RAS/MAPK resistance issues linked to KRAS G12C inhibitors. Preliminary data suggests ERAS-007 may effectively counteract drug resistance mechanisms. The trial will be led by renowned investigators, with additional research planned to assess the safety and efficacy of this combination.

Erasca, Inc. (Nasdaq: ERAS) announced key appointments aimed at advancing its clinical development efforts in precision oncology. Shannon Morris, M.D., Ph.D., joins as Senior Vice President of Clinical Development, bringing over 20 years of experience in oncology. Amy Grekowicz Parker is appointed Vice President of Clinical Operations, with a strong background in managing clinical studies. John Lo, Ph.D., takes on the role of Senior Commercial Advisor, leveraging his extensive expertise in biopharmaceutical commercialization. These strategic appointments are expected to bolster Erasca's pipeline focused on RAS/MAPK pathway-driven cancers.

Erasca, Inc. (Nasdaq: ERAS) reported its Q1 2022 financials, highlighting a cash position of $421.8 million expected to support operations into H2 2024. The company continues to progress its pipeline, with initial Phase 1b data for ERAS-007 and ERAS-601 expected in H2 2022, alongside an IND filing for ERAS-3490. R&D expenses rose significantly to $27.4 million, impacting net loss, which increased to $36.5 million or $(0.31) per share compared to last year. Encouraging preclinical and clinical developments were presented at the AACR Annual Meeting.