Welcome to our dedicated page for Esperion Therape news (Ticker: ESPR), a resource for investors and traders seeking the latest updates and insights on Esperion Therape stock.
Esperion Therapeutics, Inc. (ESPR) is a biopharmaceutical innovator focused on developing oral non-statin therapies for cardiovascular patients with elevated LDL cholesterol. This dedicated news hub provides investors and healthcare professionals with timely updates on the company’s clinical advancements, regulatory milestones, and strategic initiatives.
Access ESPR’s latest press releases covering FDA approvals, clinical trial results, and partnership announcements with global pharmaceutical leaders. Our curated collection includes earnings reports, research breakthroughs, and market expansion updates—all essential for understanding the company’s position in cholesterol management innovation.
Discover updates on bempedoic acid developments, international licensing agreements, and R&D pipeline progress. This resource serves as your primary source for tracking ESPR’s mission to address unmet needs in cardiovascular care through targeted therapeutic solutions.
Bookmark this page for streamlined access to verified Esperion Therapeutics announcements. Check regularly for new insights into one of biopharma’s most focused approaches to LDL-C reduction without statin-related limitations.
Esperion (NASDAQ: ESPR) said bempedoic acid was recommended by the 2025 ACC Scientific Statement for LDL-C lowering in adults with peripheral artery disease (PAD) and diabetes on maximally tolerated statins.
The statement endorses LDL-C reduction >50% and goal <55 mg/dL using therapies with proven cardiovascular benefit, listing bempedoic acid alongside high-intensity statins, ezetimibe, and PCSK9 inhibitors. Analysis cited from CLEAR Outcomes reported a 36% reduction in major adverse limb events (MALE) versus placebo. Product indications and safety risks for NEXLIZET and NEXLETOL are reiterated, including hyperuricemia and tendon rupture warnings.
Esperion (NASDAQ: ESPR) announced inducement equity grants dated December 4, 2025 under its 2017 Inducement Equity Incentive Plan. The company granted an aggregate of 380,000 non‑qualified stock options and 435,536 restricted stock units (RSUs), with John Harlow, the new Chief Commercial Officer, receiving 380,000 options and 424,536 RSUs. The option exercise price is $3.79, equal to the December 4, 2025 closing share price.
Vesting: 25% at the one‑year anniversary of each recipient’s vesting commencement date, then the remaining 75% in twelve equal quarterly installments, subject to continued employment and plan terms.
Esperion (NASDAQ: ESPR) announced that partner Otsuka received National Health Insurance price listing and launched NEXLETOL (bempedoic acid) in Japan on Nov 21, 2025 for treatment of hypercholesterolemia and familial hypercholesterolemia.
Under the collaboration, Esperion will receive a $90 million near-term payment tied to product and pricing approvals, is eligible for additional sales milestone payments, and will earn tiered royalties of 15%–30% on net sales in Japan. The company noted Japan is the third largest global market for cardiovascular prevention, making the launch a significant commercial milestone.
Esperion (NASDAQ: ESPR) will present at the Piper Sandler 37th Annual Healthcare Conference in New York on December 3, 2025 at 3:30 p.m. ET.
Investors can access a live webcast on Esperion's investor website; a replay will be available approximately two hours after the call and archived for about 90 days. Esperion is a commercial-stage biopharmaceutical company developing oral, once-daily, non-statin medicines for patients with elevated LDL-C, supported by the nearly 14,000-patient CLEAR Cardiovascular Outcomes Trial. The company is advancing next-generation ATP citrate lyase inhibitors (ACLYi) and pursuing commercial execution and international partnerships.
Esperion (NASDAQ: ESPR) said partner HLS Therapeutics received Health Canada approval to market NILEMDO (bempedoic acid) for the reduction of LDL-cholesterol in Canadians at risk of cardiovascular disease.
Commercial launch in Canada is expected in Q2 2026. The announcement is positioned as part of Esperion's global strategy to expand access to bempedoic acid products.
The release cites Government of Canada figures that about 2.6 million adults (one in 12 aged 20+) live with diagnosed heart disease and that heart disease is the second leading cause of death in Canada, with roughly 14 adults aged 20+ dying every hour from diagnosed heart disease.
Esperion (NASDAQ: ESPR) presented two post hoc analyses from CLEAR Outcomes at AHA Scientific Sessions 2025 (Nov 7-10). In ~8,200 patients receiving no background lipid‑lowering therapy, bempedoic acid monotherapy lowered LDL‑C by 20.6% at 6 months and reduced MACE‑4 by 14% versus placebo. A separate exploratory analysis reported a 42% lower risk of venous thromboembolism (VTE) with bempedoic acid (106 VTE events over 40.6 months); DVT risk -44% and PE risk -39% versus placebo. Safety profiles were reported as similar for total and serious adverse events; labeling warns about hyperuricemia and tendon rupture.
Esperion (NASDAQ: ESPR) announced that on November 4, 2025 it granted 77,650 restricted stock units (RSUs) to 23 new employees under its 2017 Inducement Equity Incentive Plan pursuant to NASDAQ Rule 5635(c)(4).
The RSUs vest 25% on the one-year anniversary of each recipient’s vesting commencement date and the remaining 75% in twelve equal quarterly installments thereafter, subject to continued employment. The awards are governed by the 2017 Inducement Equity Incentive Plan and individual RSU agreements.
Esperion is a commercial-stage biopharmaceutical company commercializing FDA-approved oral, once-daily non-statin medicines for patients with elevated LDL-C and references the nearly 14,000-patient CLEAR Cardiovascular Outcomes Trial.
Esperion (NASDAQ: ESPR) reported Q3 2025 total revenue of $87.3M, up 69% year‑over‑year, driven by U.S. prescription volume and expanded payer coverage. U.S. net product revenue was $40.7M, up 31% Y/Y. The company announced a settlement with ANDA filer Dr. Reddy’s and three other filers preventing generic marketing of NEXLETOL and NEXLIZET prior to April 2040. Bempedoic acid received a Class I, Level A recommendation in the 2025 ESC/EAS guidelines. Partner Otsuka received Japanese approval and favorable preliminary pricing for NEXLETOL, which will trigger material milestone payments upon final pricing.
Esperion ended Q3 with $92.4M cash, reported a Q3 net loss of $31.3M, reiterated 2025 operating expense guidance of $215M–$235M, and expects sustainable profitability beginning Q1 2026.
Esperion (NASDAQ: ESPR) announced the appointment of John Harlow as Chief Commercial Officer, effective November 17, 2025. He will report to President and CEO Sheldon Koenig and join the executive leadership team.
Harlow joins from Melinta Therapeutics, where he served as CCO and led a commercial platform and team of ~80 employees, helping drive roughly 85% revenue growth in 2024 vs 2020. He has prior commercial leadership roles at Baudax Bio, Recro Pharma, Endo, Shionogi USA, Pfizer, Alpharma, and Novartis, plus an MBA in Pharmaceutical Management and Marketing.
Esperion cited Harlow’s experience as central to expanding U.S. adoption and the global footprint for its therapies NEXLETOL and NEXLIZET.
Esperion (NASDAQ: ESPR) will present at the Jefferies Global Healthcare Conference – London on November 18, 2025 at 8:00 a.m. GMT (3:00 a.m. ET).
The presentation will be webcast live and accessible via the company investor website. A replay will be available approximately two hours after the call and will be archived on the company website for approximately 90 days. Esperion is a commercial-stage biopharmaceutical company developing oral, once-daily, non-statin medicines for patients with elevated LDL-C and is advancing next-generation ACLY inhibitor programs supported by prior CLEAR outcomes research.
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