Evaxion presents new preclinical data for cytomegalovirus vaccine program EVX-V1
Rhea-AI Summary
Evaxion (NASDAQ: EVAX) reported new preclinical data from its cytomegalovirus (CMV) vaccine program EVX‑V1, presented in a poster at the International Herpesvirus Workshop 2026 in Montreal. EVX‑V1 is a next‑generation, multi‑component CMV vaccine program created with Evaxion’s AI‑Immunology™ platform.
The vaccine concept combines AI‑discovered T‑cell epitopes and novel B‑cell antigens with AI‑optimized versions of established structural B‑cell antigens, aiming at broader multi‑targeted immune coverage. According to Evaxion, the new data in CMV‑infected mice indicate potential to improve control of acute infection, latency and viral reactivation, complementing earlier preclinical findings of reduced viral infection and superior viral neutralization. The company highlights CMV as a major unmet need, particularly for immunocompromised individuals and infants, with no licensed vaccine currently available.
Positive
- New preclinical data support EVX‑V1 multi‑component CMV vaccine concept
- AI‑discovered T‑cell epitopes show potential to improve CMV control in mice
- Novel B‑cell antigens previously showed reduced viral infection in preclinical models
- Optimized structural B‑cell antigens mediated superior viral neutralization preclinically
- Scalable vaccine design concept proposed across other herpesviruses
Negative
- None.
Key Figures
Historical Context
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Jul 01 | Preclinical CMV data | Positive | +3.2% | Announcement of upcoming EVX-V1 CMV preclinical data poster at IHW 2026. |
| Jun 12 | Innovation award | Positive | +5.3% | AI-Immunology platform receiving 2026 Prix Galien UK Award for digital health. |
| Jun 11 | AML vaccine data | Positive | -4.8% | New preclinical data for EVX-04 AML vaccine showing immune activation and tumor control. |
| May 12 | AML data preview | Positive | -1.3% | Planned EVX-04 preclinical data presentation at EHA 2026 with step toward clinical testing. |
| May 07 | Q1 2026 earnings | Negative | -7.7% | Wider quarterly net loss and cash runway update alongside AI platform progress. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Recent news has produced mixed reactions, with most events aligning with their tone but some positive R&D updates seeing negative price moves.
Key Terms
cytomegalovirus medical
t-cell epitopes medical
b-cell antigens medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
- The new data demonstrates the potential to improve control of acute infection, latency, and viral reactivation, further supporting the concept behind EVX-V1
- EVX-V1 is a next-generation, multi-component vaccine program combining novel AI-discovered antigens with AI-optimized versions of established CMV vaccine antigens
- Data presented today in poster presentation at the International Herpesvirus Workshop 2026 taking place in Montreal, Canada
COPENHAGEN, Denmark, July 12, 2026 - Evaxion A/S (NASDAQ: EVAX) (“Evaxion”), a clinical-stage TechBio company developing novel vaccines with its pioneering AI-Immunology™ platform, presents new data further supporting the multi-component concept of its cytomegalovirus (CMV) vaccine program EVX-V1.
Data is presented today in a poster session at the International Herpesvirus Workshop (IHW) 2026 taking place in Montreal, Canada.
EVX-V1 is a next-generation, multi-component CMV vaccine program designed with AI-Immunology™. It combines novel protective B-cell antigens and T-cell epitopes complemented by known optimized structural B-cell antigens
This broader multi-targeted strategy is expected to strengthen the protective potential of a future vaccine. The concept represents a scalable strategy for rational vaccine development across other herpesviruses.
“We are excited by the new data which will guide the selection of antigens for a broadly protective CMV vaccine candidate and as such represent an important step forward for the EVX-V1 program. CMV remains a major clinical challenge, causing severe disease in immunocompromised individuals and infants, yet no licensed vaccine exists. EVX-V1 holds the potential to transform the future CMV treatment landscape,” says Birgitte Rønø, CSO and COO of Evaxion.
The new data show that the AI-Immunology™ discovered novel T-cell epitopes have the potential to improve control of acute infection, latency and reactivation in CMV-infected mice. This complements previous findings of the novel B-cell antigens significantly reducing viral infection in preclinical models and the optimized known structural B-cell antigens mediating superior viral neutralization.
About EVX-V1
EVX-V1 is a next-generation, multi-component cytomegalovirus (CMV) vaccine candidate combining novel AI-discovered antigens with AI-optimized versions of established CMV vaccine antigens. Through this combination, EVX-V1 attacks the virus from multiple, complementary angles. This broader multi-targeted strategy is expected to strengthen the protective potential of the vaccine.
With our AI-Immunology™ platform, we have uncovered novel antigens that are entirely new to the CMV vaccine research field. These previously unexplored CMV-antigens induce specific immune responses, inhibit viral infection and reduce cell-to-cell spread in cellular and animal viral infection models.
EVX-V1 is a combination of these antigens with our proprietary AI-optimized pre-fusion glycoprotein B (gB) antigen which has demonstrated superior performance compared to the traditional gB antigen, including enhanced CMV neutralization.
About CMV
About 1 in 200 babies is born with congenital CMV infection. About 1 in 5 babies with the infection will have congenital disabilities or other long-term health problems. CMV infects approximately
CMV treatment market size was valued at
CMV is the most complex of all herpes viruses and is a widespread infection transmitted in body fluids. Once infected, the virus stays for life. People with weakened immune systems, including organ transplant patients, can develop severe symptoms affecting, for example, eyes, lungs, and liver, and congenitally infected babies may suffer from intellectual disability and loss of vision and hearing.
Contact information
Evaxion A/S
Mads Kronborg
Vice President, Investor Relations & Communication
+45 53 54 82 96
mak@evaxion.ai
About Evaxion
Evaxion is a pioneering TechBio company based upon its proprietary, clinically validated and scalable AI platform, AI-Immunology™. The platform harnesses the power of artificial intelligence to decode the human immune system and develop novel vaccine candidates for cancer and infectious diseases.
With AI-Immunology™ we conduct rapid, efficient and high-quality target discovery, drug design and development. Our team of +40 experts covers the entire value chain from target discovery to clinical development
We have developed a clinical pipeline of both personalized and off-the-shelf cancer vaccine candidates as well as prophylactic vaccine candidates for infectious diseases. All our candidates address high unmet medical needs, reflecting our commitment to transforming patients’ lives by providing innovative and targeted treatment options.
For more information about Evaxion, AI-Immunology™ and our pipeline, please visit our website.
Forward-looking statement
This announcement contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. The words “target,” “believe,” “expect,” “hope,” “aim,” “intend,” “may,” “might,” “anticipate,” “contemplate,” “continue,” “estimate,” “plan,” “potential,” “predict,” “project,” “will,” “can have,” “likely,” “should,” “would,” “could,” and other words and terms of similar meaning identify forward-looking statements. Actual results may differ materially from those indicated by such forward-looking statements as a result of various factors, including, but not limited to, risks related to: our financial condition and need for additional capital; our development work; cost and success of our product development activities and preclinical and clinical trials; commercializing any approved pharmaceutical product developed using our AI platform technology, including the rate and degree of market acceptance of our product candidates; our dependence on third parties including for conduct of clinical testing and product manufacture; our inability to enter into partnerships; government regulation; protection of our intellectual property rights; employee matters and managing growth; our ADSs and ordinary shares, the impact of international economic, political, legal, compliance, social and business factors, including inflation, and the effects on our business from other significant geopolitical and macro-economic events; and other uncertainties affecting our business operations and financial condition. For further discussion of these risks, please refer to the risk factors included in our most recent Annual Report on Form 20-F and other filings with the US Securities and Exchange Commission (SEC), which are available at www.sec.gov. We do not assume any obligation to update any forward-looking statements except as required by law.
