Foghorn Therapeutics Inc. Stock Price, News & Analysis

YourBio Health and Flagship Pioneering have announced the appointment of Paul Owen as CEO of YourBio Health and CEO-Partner of Flagship Pioneering. Owen brings over 35 years of corporate leadership experience, most recently serving as Board Director and President of Oncodea.

YourBio Health's key product, the Touch-Activated Phlebotomy (TAP®) device, is the first push-button blood collection technology using microneedles for virtually painless blood draws. The technology has been implemented in clinical trials, diagnostic settings, and wellness applications, with millions of blood collections completed since its commercial launch.

The company has established partnerships with biopharmaceutical companies, genetic companies, and academic research hospitals. The announcement also includes concurrent appointments to YourBio's leadership team, adding expertise in medical device product innovation, clinical strategy, and commercialization.

Foghorn Therapeutics (NASDAQ: FHTX) has announced its strategic objectives for 2025, highlighting progress across multiple programs. The company's first-in-class oral selective SMARCA2 inhibitor, FHD-909, is advancing in Phase 1 trials for SMARCA4 mutated cancers, primarily targeting non-small cell lung cancer (NSCLC). Preclinical combination data with pembrolizumab and KRAS inhibitors will be presented at the AACR Annual Meeting in April 2025.

The company has achieved selective degradation of ARID1B, a synthetic lethal target implicated in up to 5% of all solid tumors, with an update expected in 2025. Foghorn is also advancing its Selective CBP degrader and Selective EP300 degrader programs. The company maintains a strong financial position with $243.8 million in cash, cash equivalents, and marketable securities, providing runway into 2027.

Foghorn Therapeutics (FHTX) announced the discontinuation of independent development for FHD-286 in combination with decitabine for relapsed/refractory acute myeloid leukemia (AML). While objective clinical responses were observed in the Phase 1 dose escalation trial, the response rate didn't meet the company's continuation threshold.

The company will now focus on its proprietary pipeline and Lilly collaboration programs, including the clinical-stage selective SMARCA2 inhibitor FHD-909. As of September 30, 2024, Foghorn reported $267.4 million in cash, cash equivalents, and marketable securities, providing runway into 2027. Trial results are expected to be presented at a medical conference in 2025.

Foghorn Therapeutics (NASDAQ: FHTX), a clinical-stage biotech company, announces its participation in three major investor conferences. The company, which focuses on developing medicines targeting abnormal gene expression through its Gene Traffic Control® platform, will present at:

- Jefferies London Healthcare Conference on November 19, 2024 (11:30 AM GMT)
- 7th Annual Evercore HealthCONx Conference on December 3, 2024 (1:20 PM EST)
- Citi Global Healthcare Conference on December 4, 2024

CEO Adrian Gottschalk will lead fireside chats at Jefferies and Evercore events, with one-on-one meetings scheduled at all three conferences. Webcasts will be available on the company's website for 30 days.

Foghorn Therapeutics reports Q3 2024 financial results and pipeline updates. Key highlights include: First patient dosed with FHD-909 in Phase 1 trial for SMARCA4 mutated NSCLC; Topline Phase 1 data for FHD-286 plus decitabine in AML expected by year-end 2024; IND-enabling studies for Selective CBP degrader program to begin by year-end. Financial position: $267.4M cash runway into 2027; Q3 revenue at $7.8M (down from $17.5M in Q3 2023); Net loss increased to $19.1M from $14.3M year-over-year.

Foghorn Therapeutics (Nasdaq: FHTX) has announced the dosing of the first patient with FHD-909, a first-in-class oral SMARCA2 selective inhibitor, in a Phase 1 trial for SMARCA4 mutated solid tumors. The primary target population is non-small cell lung cancer (NSCLC). This trial is part of a U.S. 50/50 co-development and co-commercialization collaboration with Lilly, who leads the clinical development.

FHD-909 is a highly potent and selective compound targeting SMARCA2 over SMARCA4. The Phase 1 open-label, multicenter trial will assess safety, tolerability, and initial efficacy in patients with locally advanced or metastatic solid tumors harboring SMARCA4 alterations. Preclinical studies have shown promising results, including robust anti-tumor activity and favorable tolerability.

Foghorn Therapeutics Inc. (Nasdaq: FHTX), a clinical-stage biotechnology company, has announced its participation in investor meetings at the BMO Oncology Summit on October 8, 2024, in New York, NY. The company is pioneering a new class of medicines that aim to correct abnormal gene expression to treat serious diseases.

Foghorn's Gene Traffic Control® platform and resulting broad pipeline focus initially on oncology but have the potential to address a wide spectrum of diseases. This innovative approach could potentially transform the lives of many patients suffering from various conditions.

Foghorn Therapeutics (Nasdaq: FHTX) has appointed Anna Rivkin, Ph.D., as Chief Business Officer effective September 3, 2024. Dr. Rivkin brings over 20 years of experience in complex business transactions across multiple disease areas. Previously, she held leadership roles at Bristol Myers Squibb, overseeing strategic transactions as Vice President of Business Development. Dr. Rivkin has led transactions valued at over $35 billion, including the $14 billion purchase of Karuna Therapeutics and the $13 billion purchase of MyoKardia Therapeutics.

Foghorn, a clinical-stage biotechnology company, focuses on developing medicines that correct abnormal gene expression to treat serious diseases. The company views Dr. Rivkin's appointment as strategic for leveraging its pipeline and platform potential during its growth phase.

Foghorn Therapeutics (Nasdaq: FHTX), a clinical-stage biotech company, announced its participation in two upcoming investor conferences in September 2024. The company will attend the Wells Fargo Healthcare Conference on September 4 for one-on-one meetings. At the Morgan Stanley 22nd Annual Global Healthcare Conference on September 6, Foghorn's President and CEO, Adrian Gottschalk, will give a presentation at 8:30 a.m. EDT and participate in one-on-one meetings.

Foghorn is pioneering a new class of medicines that correct abnormal gene expression to treat serious diseases, with an initial focus on oncology. Their Gene Traffic Control® platform and broad pipeline aim to transform lives across various diseases. A webcast of the Morgan Stanley presentation will be available on the company's website for 30 days.