GE HealthCare announces lead industrial role in largest EU-funded IHI consortium to advance cardio-oncology care across Europe

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cardiotoxicity medical

Cardiotoxicity is damage to the heart caused by a drug, chemical or medical treatment that can weaken heart function, disrupt heartbeat or cause inflammation. It matters to investors because evidence of cardiotoxicity can halt or delay product approvals, trigger costly additional testing, recalls or legal risk, and reduce future revenue potential—similar to how rust in an engine can undermine a machine’s reliability and resale value.

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Molecular imaging is a medical technique that uses specialized scans and tracers to see biological processes at the cellular or molecular level inside the body, like using a GPS to track where activity is happening rather than just taking a photo. For investors, it matters because these tools can speed diagnosis, guide drug development, and help companies demonstrate a therapy’s effect earlier and more precisely, potentially reducing time and cost to market.

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Multi-omics is a comprehensive approach that combines different types of biological data—such as genetic information, proteins, and other molecules—to gain a detailed understanding of how living systems function. For investors, this approach can reveal insights into health, disease, or biological processes that may influence the development of new treatments or technologies, potentially impacting market opportunities and innovation in healthcare.

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Wearable data is the information collected by devices you wear, such as smartwatches, fitness bands, or medical patches, that track activity, heart rate, sleep, and other body or location signals. For investors, it matters because the volume, accuracy and use of that data drive product value, recurring services, partnerships and regulatory risk—much like how a home’s smart meter makes energy use visible and creates new business opportunities and liabilities.

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• COMPASS is one of the largest public‑private partnerships under the European Union’s (EU) Innovative Health Initiative (IHI).
• The consortium aims to advance early detection and prediction of cardiotoxicity in cancer patients and cancer survivors.
• The initiative will leverage AI, advanced imaging, biomarkers, and integrated care pathways.

CHICAGO--(BUSINESS WIRE)-- GE HealthCare (Nasdaq: GEHC) today announced its leading industrial role in the new COMPASS consortium, a five-year initiative focused on improving precision cardio-oncology care and advancing early detection of cardiovascular risks in cancer patients across Europe. COMPASS combines clinical excellence with novel healthcare technology, and with a total budget of €50.5 million and more than sixty partners, it is one of the largest public-private partnerships under the IHI.

Cardiovascular diseases are rising sharply among cancer patients and survivors, driven both by the increasing prevalence of pre‑existing cardiovascular conditions at diagnosis and by the expanding use of highly effective antitumor therapies - including chemotherapy, radiotherapy and targeted therapies - many of which are associated with cardiovascular toxicities. Global studiesⁱ show that heart-related complications are now the second leading cause of death in cancer survivors, after the cancer itself, accounting for up to 10% of mortality. Despite the broad recognition of cardiotoxicity as a major clinical challenge, evidence-based approaches to its management remain restricted. Limited understanding of the biological mechanisms underlying cardiotoxicity, a lack of reliable biomarkers, and the absence of effective preventive strategies, heighten patient risks and place growing pressure on healthcare systems, particularly in Europe’s aging population.

Across Europe, the COMPASS partners aim to improve the cardiovascular health of cancer patients and survivors through a comprehensive, end-to-end, patient centered clinical pathway, enabling timely intervention and safer continuation of cancer therapy while reducing the risk of cardiovascular complications. By fostering multidisciplinary collaboration, regulatory alignment, as well as patient awareness and engagement, COMPASS aims to ensure that clinically meaningful innovations are effectively translated into routine healthcare practice within Europe.

“King’s College London is looking forward to providing academic leadership and scientific coordination to COMPASS, harnessing the consortium expertise across cardiology, oncology, molecular science, big data and AI to address the increasing challenge in cardiotoxicity in cancer care,” said Steve Archibald, Professor in Molecular Imaging, School of Biomedical Engineering & Imaging Sciences, King’s College London. “We aim to promote integrated care models to drive widespread adoption across healthcare systems.”

The program intends to predict cardiotoxicity risk, detect cardiovascular disease at an earlier stage, coordinate and personalize cancer and cardiovascular care, supporting patients in daily life, and managing long-term cardiovascular effects of cancer treatment. To achieve this, COMPASS will focus on the following areas:

• Identification of novel biomarkers for cardiotoxicity diagnosis and risk stratification: advancing the early detection of cardiotoxicity through innovative molecular imaging, advanced cardiac imaging techniques, and multi-omics biomarker discovery, which integrates genetic, molecular, and metabolic data to enable earlier, more precise disease prediction and diagnosis.
• AI-enabled predictive and clinical decision support tools: leveraging AI to integrate real-world data, imaging, non-imaging, biomarkers and wearable data into predictive models and decision-support tools for personalized care in clinical settings.
• Improved care delivery and enhanced patient engagement: promoting integrated care pathways, patient education and stakeholder engagement to ensure equitable access, long-term follow-up and patient-centred outcomes.

“This initiative is well positioned to enable patient-centered cancer care that takes cardiotoxicity risk into account, supports the early detection of cardiotoxic side-effects, and promotes long-term heart health for oncology patients,” said Eigil Samset, General Manager, Cardiology Solutions at GE HealthCare and COMPASS Industry Lead. “We are honored to play an integral part as industry lead in this multidisciplinary collaboration which brings together the expertise of leading European academic, clinical, industry, and patient advocacy groups. By developing an AI-powered, integrated care pathway that connects oncologists and cardiologists in clinical practice, this collaboration has the potential to further improve cancer survival by tackling cardiovascular-related morbidity.”

The project is co-funded under the Horizon Europe framework, as part of IHI which is a public-private partnership between the European Union and the European life science industries. The Joint Undertaking (IHI JU) under grant agreement Nr. #101253264 receives support from the European Union’s Horizon Europe research and innovation program and from COCIR, EFPIA, Europa Bío, MedTech Europe, Vaccines Europe and COMPASS contributing partners. The grant agreement was signed on March 25, 2026, and runs through the next five years. For more information and for the full list of consortium members, please visit the IHI website.

About GE HealthCare Technologies Inc.

GE HealthCare is a leading global healthcare solutions provider of advanced medical technology, pharmaceutical diagnostics, and AI, cloud and software solutions that help clinicians tackle the world’s most complex diseases. Serving patients and providers for 130 years, GE HealthCare is delivering bold innovations designed for the next era of medicine across its Imaging, Advanced Visualization Solutions, Patient Care Solutions, and Pharmaceutical Diagnostics segments to help clinicians deliver more personalized, precise patient care. We are a $20.6 billion business with approximately 54,000 colleagues working to create a world where healthcare has no limits.

GE HealthCare is proud to be among 2026 Fortune World’s Most Admired Companies™.

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ⁱ MDPI. Cardiotoxicity of Chemotherapy: A Multi-OMIC Perspective January 8. 2025. https://www.mdpi.com/2039-4713/15/1/9

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GE HealthCare Media Contact:
Karin Dalsin
M +1 612-219-2855
Karin.Dalsin@gehealthcare.com

Source: GE HealthCare