Geron Corporation Reports Second Quarter 2026 Financial Results and Recent Business Highlights
Rhea-AI Summary
Geron (Nasdaq: GERN) reported second quarter 2026 RYTELO® (imetelstat) net product revenue of $57.5 million, up 11% versus Q1 2026 and above $49.0 million a year ago. Total Q2 revenues were $57.5 million, with a net loss of $16.7 million, or $0.02 per share.
Total Q2 costs and operating expenses were $70.0 million, up from $61.5 million, driven primarily by non-cash inventory-related expenses, as cost of goods sold rose to $9.2 million. Geron ended Q2 2026 with $326.9 million in cash, cash equivalents, restricted cash and marketable securities.
For full-year 2026, Geron reiterated guidance for RYTELO net product revenue of $220–$240 million and total operating expenses of $230–$240 million. The company highlighted continued RYTELO demand growth, expansion of ordering accounts, real-world and clinical data presentations, and the appointment of a new Chief Business Officer.
Positive
- RYTELO net product revenue $57.5M in Q2 2026, +11% QoQ
- Total revenues $57.5M in Q2 2026 vs. $49.0M in Q2 2025
- First-half 2026 RYTELO net revenue $109.2M, up 24% vs. $88.4M
- Q2 2026 RYTELO demand +5% QoQ; ordering accounts ~1,575, +8%
- Cash and securities $326.9M at June 30, 2026
- 2026 guidance reiterated: RYTELO revenue $220–$240M; opex $230–$240M
Negative
- Q2 2026 net loss $16.7M, or $0.02 per share
- Total Q2 2026 costs/opex $70.0M vs. $61.5M in Q2 2025
- Cost of goods sold $9.2M in Q2 2026 vs. $1.2M a year ago
- Cash and securities decreased to $326.9M from $341.0M on March 31, 2026
News Explained
Geron’s completed second-quarter reporting event adds a liquidity update: cash, cash equivalents, restricted cash and marketable securities were
Key Figures
Previous Earnings Reports
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| May 06 | Q1 2026 earnings | Positive | -4.2% | RYTELO revenue growth, reduced net loss, reiterated guidance, and ongoing clinical progress |
| Feb 25 | Q4 2025 earnings | Positive | -11.8% | Full-year RYTELO revenue, 2026 guidance, cash funding outlook, and commercial demand growth |
| Nov 05 | Q3 2025 earnings | Positive | -5.2% | Revenue growth, narrowed net loss, completed trial enrollment, and lower expense guidance |
| Aug 06 | Q2 2025 earnings | Positive | +15.8% | RYTELO revenue growth, leadership appointment, reduced net loss, and clinical enrollment progress |
| May 07 | Q1 2025 earnings | Positive | -0.8% | European authorization, myelofibrosis enrollment, cash position, and maintained expense guidance |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Geron’s tag-specific earnings reactions were negative in four of five events, including the prior quarter, despite generally positive reported business updates.
Key Terms
real-world evidence medical
telomerase inhibitor medical
myelofibrosis medical
transfusion-dependent anemia medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
Achieved
Reiterated 2026 RYTELO net product revenue and total operating expenses expected to be in the ranges of
Ended Q2 2026 with cash, cash equivalents, restricted cash and marketable securities of
Broadened leadership team with the appointment of Chinmaya Rath as Chief Business Officer
Company to host conference call and webcast today, August 5, 2026, at 8:00 a.m. ET
FOSTER CITY, Calif., Aug. 05, 2026 (GLOBE NEWSWIRE) -- Geron Corporation (Nasdaq: GERN), a commercial-stage biopharmaceutical company aiming to change lives by changing the course of blood cancer, today reported financial results for the second quarter of 2026 and recent business highlights.
“We are executing a focused strategy to build a leading hematology company, which starts with bringing RYTELO to more eligible patients impacted by LR-MDS in the U.S. Our team delivered a third consecutive quarter of RYTELO demand growth, and in the first half of 2026, grew net revenue by
Recent Business Highlights
- Reported RYTELO net product revenue of
$57.5 million in the second quarter of 2026.- Grew RYTELO demand by
5% in the second quarter 2026, compared to the first quarter 2026. - Increased ordering accounts by roughly
8% in the second quarter 2026 to approximately 1,575.
- Grew RYTELO demand by
- Presented the first real-world evidence study of RYTELO in patients with lower-risk myelodysplastic syndromes (LR-MDS) at the European Hematology Association (EHA) 2026 Congress. The retrospective portion of the investigator-sponsored study, conducted at the Moffitt Cancer Center, reported safety and clinical efficacy of imetelstat in advanced, heavily transfusion-dependent patients with LR-MDS, including patients with extensive prior therapies and after luspatercept failure. The efficacy, safety and tolerability observed were generally consistent with findings from the Phase 3 IMerge trial in a broader patient population.1
- Presented two abstracts studying imetelstat in relapsed/refractory myelofibrosis at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, including an updated overall survival analysis from the Phase 2 IMbark trial compared with real-world data.
- Broadened the leadership team with the appointment of Chinmaya Rath as Chief Business Officer.
Second Quarter 2026 Financial Results
Cash and Marketable Securities
As of June 30, 2026, Geron had approximately
Net Loss
For the three months ended June 30, 2026, the Company reported a net loss of
Revenues
Total product revenue, net for the three months ended June 30, 2026, was
Costs and Operating Expenses
Total costs and operating expenses for the three months ended June 30, 2026, were
Cost of goods sold was approximately
Research and development expenses for the three months ended June 30, 2026, were
Selling, general and administrative expenses for the three months ended June 30, 2026, were
2026 Financial Guidance
For fiscal year 2026, the Company expects RYTELO net product revenue to be in the range of
Based on current operating plans and assumptions, the Company believes that its existing cash, cash equivalents, restricted cash and marketable securities, together with anticipated net revenues from U.S. sales of RYTELO, will be sufficient to fund projected operating requirements for the foreseeable future.
Conference Call
Geron will host a conference call at 8:00 a.m. ET on Wednesday, August 5, 2026, to discuss business updates and second quarter 2026 financial results.
A live webcast of the conference call will be available on the “Investors & Media” page of the Company’s website at www.geron.com. A replay of the webcast will be archived and available on the Company's website.
1. Data presented at the European Hematology Association (EHA) 2026 Congress: Komrokji RS, et al. “Real-world Outcomes of Imetelstat: Interrogating Safety, Efficacy and Predictors of Response in Heavily Pretreated Lower-Risk MDS Patients.” Poster PF670. June 11-14, 2026, Stockholm, Sweden.
About RYTELO (imetelstat)
RYTELO (imetelstat) is an oligonucleotide telomerase inhibitor approved in the U.S. for the treatment of adult patients with lower-risk myelodysplastic syndromes (LR-MDS) with transfusion-dependent anemia requiring four or more red blood cell units over eight weeks who have not responded to or have lost response to or are ineligible for erythropoiesis-stimulating agents (ESAs). It is indicated to be administered as an intravenous infusion over two hours every four weeks.
In addition, RYTELO is approved in the European Union as a monotherapy for the treatment of adult patients with transfusion-dependent anemia due to very low, low or intermediate risk myelodysplastic syndromes without an isolated deletion 5q cytogenetic (non-del 5q) abnormality and who had an unsatisfactory response to or are ineligible for erythropoietin-based therapy.
RYTELO is a first-in-class treatment that works by inhibiting telomerase enzymatic activity. Telomeres are protective caps at the end of chromosomes that naturally shorten each time a cell divides. In LR-MDS, abnormal bone marrow cells often express the enzyme telomerase, which rebuilds those telomeres, allowing for uncontrolled cell division. Developed and exclusively owned by Geron, RYTELO is the first and only telomerase inhibitor approved by the U.S. Food and Drug Administration and the European Commission.
Please see RYTELO (imetelstat) full Prescribing Information, including Medication Guide, available at https://pi.geron.com/products/US/pi/rytelo_pi.pdf.
About Geron
Geron is a commercial-stage biopharmaceutical company aiming to change lives by changing the course of blood cancer. Our first-in-class telomerase inhibitor RYTELO® (imetelstat) is approved in the United States and the European Union for the treatment of certain adult patients with lower-risk myelodysplastic syndromes with transfusion dependent anemia. We are also conducting a pivotal Phase 3 clinical trial of imetelstat in JAK-inhibitor relapsed/refractory myelofibrosis, as well as studies in other hematologic malignancies. To learn more, visit www.geron.com or follow us on LinkedIn.
Use of Forward-Looking Statements
Except for the historical information contained herein, this press release contains forward-looking statements made pursuant to the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. Investors are cautioned that such statements, include, without limitation, those regarding: (i) Geron’s 2026 financial guidance, including its expected full year 2026 RYTELO net product revenue range and total operating expense range; (ii) Geron being positioned to build in the future on RYTELO demand and net revenue growth in the second half of 2026; (iii) Geron’s potential European lower-risk MDS commercial strategy for RYTELO; (iv) Geron’s 2026 priorities, including remaining focused on growing RYTELO net revenue in the U.S., pursuing pathways to bring RYTELO to patients outside of the U.S., advancing its Phase 3 IMpactMF trial, remaining financially disciplined, and evaluating opportunistic innovation; (v) the expected timing of initial data from investigator-sponsored and real-world evidence trials focusing on RYTELO’s mechanistic studies, combinations and sequencing, earlier-line use and new settings; (vi) the pooled analysis from the IMerge population that suggests treatment-emergent cytopenias may reflect on-target effects associated with meaningful clinical outcomes, including hemoglobin increases and transfusion independence in LR-MDS; (vii) Geron’s belief that its existing cash, cash equivalents, restricted cash and marketable securities, together with anticipated net revenues from U.S. sales of RYTELO, will be sufficient to fund projected operating requirements for the foreseeable future; and (viii) and other statements that are not historical facts, constitute forward-looking statements. These forward-looking statements involve risks and uncertainties that can cause actual results to differ materially from those in such forward-looking statements. These risks and uncertainties, include, without limitation, risks and uncertainties related to: (a) whether Geron is successful in commercializing RYTELO for the treatment of certain patients with lower-risk MDS with transfusion dependent anemia and achieves market acceptance across the breadth of the eligible patient segments in RYTELO’s approved indication; (b) whether the FDA, European Commission and other regulatory authorities will approve imetelstat for other indications with labeling claims that are necessary or desirable for the successful commercialization of RYTELO and without significant labeling restrictions or requirements in an approved label; (c) Geron’s plans to commercialize RYTELO outside of the U.S., including Geron’s lack of experience selling, marketing and commercializing an approved drug outside of the U.S., and risks related to pricing, reimbursement, distribution, supply chain and other operational requirements of operating outside of the U.S.; (d) Geron’s future opportunities and plans, including the uncertainty of future revenues, expenses and other financial performance and results, and the related risk that Geron may be unable to meet its 2026 financial guidance; (e) whether Geron overcomes potential delays and other adverse impacts that may be caused by enrollment, clinical, safety, efficacy, technical, scientific, intellectual property, manufacturing, supply chain, pricing, coverage and reimbursement, market penetration, regulatory, healthcare or geopolitical challenges in order to obtain and maintain the financial resources for and meet expected timelines and planned milestones; (f) whether regulatory authorities permit the further development of imetelstat on a timely basis, or at all, without any clinical holds; (g) whether any future safety or efficacy results of RYTELO treatment cause its benefit-risk profile to become unacceptable or negatively impact commercialization, regulatory approvals or clinical development; (h) whether imetelstat actually demonstrates disease-modifying activity in patients, including transfusion independence in LR-MDS, and the ability to target the malignant stem and progenitor cells of the underlying disease; (i) whether Geron meets its post-marketing requirements and commitments for RYTELO; (j) whether there are failures or delays in manufacturing or supplying sufficient quantities of RYTELO (imetelstat) or other clinical trial materials that negatively impact commercialization of RYTELO or the conduct and timing of clinical trials; (k) that the expected timing for initial data from investigator-sponsored and real-world evidence trials may be delayed, perhaps significantly; (l) that the projected timing for the interim and final analyses of the Phase 3 IMpactMF trial may prove to be incorrect and may be delayed, perhaps significantly, depending on actual death rates in the trial which are beyond Geron’s control; (m) whether Geron stays in compliance with and satisfies its obligations under its debt and synthetic royalty financing agreements; (n) whether Geron successfully manages the changes in its workforce and realizes expected operating expense savings and business efficiencies resulting from its completed strategic restructuring plan; and (o) as it relates to Geron’s belief as to the sufficiency of its cash resources, if Geron does not generate net revenues from commercial sales of RYTELO at the levels it anticipates, if it experiences unforeseen events or chooses to make other investments in its business, or if its assumptions regarding its projected operating expenses are otherwise incorrect, Geron may require additional funding, which may not be available to Geron on commercially-reasonable terms or at all. Additional information on the above risks and uncertainties and additional risks, uncertainties and factors that could cause actual results to differ materially from those in the forward-looking statements are contained in Geron’s filings and periodic reports filed with the Securities and Exchange Commission under the heading “Risk Factors” and elsewhere in such filings and reports, including Geron’s annual report on Form 10-K for the year ended December 31, 2025, Geron’s quarterly report on Form 10-Q for the quarter ended March 31, 2026, and Geron’s upcoming quarterly report on Form 10-Q for the quarter ended June 30, 2026, and subsequent filings and reports by Geron. Undue reliance should not be placed on forward-looking statements, which speak only as of the date they are made, and the facts and assumptions underlying the forward-looking statements may change. Except as required by law, Geron disclaims any obligation to update these forward-looking statements to reflect future information, events, or circumstances.
| GERON CORPORATION | |||||||||||||||
| CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS | |||||||||||||||
| Three Months Ended June 30, | Six Months Ended June 30 | ||||||||||||||
| (in thousands, except per share data) | 2026 | 2025 | 2026 | 2025 | |||||||||||
| (Unaudited) | (Unaudited) | (Unaudited) | (Unaudited) | ||||||||||||
| Revenues: | |||||||||||||||
| Product revenue, net | $ | 57,473 | $ | 49,007 | $ | 109,244 | $ | 88,443 | |||||||
| Royalties | 7 | 29 | 73 | 196 | |||||||||||
| Total revenues | 57,480 | 49,036 | 109,317 | 88,639 | |||||||||||
| Costs and operating expenses: | |||||||||||||||
| Cost of goods sold | 9,240 | 1,190 | 10,932 | 2,396 | |||||||||||
| Research and development | 22,030 | 21,736 | 36,986 | 36,814 | |||||||||||
| Selling, general and administrative | 38,863 | 38,564 | 74,288 | 78,587 | |||||||||||
| Restructuring charges | (157 | ) | - | (551 | ) | - | |||||||||
| Total costs and operating expenses | 69,976 | 61,490 | 121,655 | 117,797 | |||||||||||
| Loss from operations | (12,496 | ) | (12,454 | ) | (12,338 | ) | (29,158 | ) | |||||||
| Interest income | 2,971 | 4,656 | 6,392 | 9,808 | |||||||||||
| Interest expense | (7,146 | ) | (8,516 | ) | (14,293 | ) | (16,716 | ) | |||||||
| Other income (expense), net | (9 | ) | (61 | ) | (83 | ) | (144 | ) | |||||||
| Net loss | $ | (16,680 | ) | $ | (16,375 | ) | $ | (20,322 | ) | $ | (36,210 | ) | |||
| Basic and diluted net loss per share | $ | (0.02 | ) | $ | (0.02 | ) | $ | (0.03 | ) | $ | (0.05 | ) | |||
| Weighted-average shares used in calculating basic and diluted net loss per share | 670,696 | 666,170 | 670,039 | 666,039 | |||||||||||
| GERON CORPORATION | |||||||
| CONDENSED CONSOLIDATED BALANCE SHEETS | |||||||
| June 30, 2026 | December 31, 2025 | ||||||
| (in thousands) | (Unaudited) | (Note 1) | |||||
| Current assets: | |||||||
| Cash, cash equivalents and restricted cash | $ | 64,531 | $ | 79,440 | |||
| Current marketable securities | 238,206 | 280,359 | |||||
| Other current assets | 183,602 | 160,472 | |||||
| Total current assets | 486,339 | 520,271 | |||||
| Noncurrent marketable securities | 24,122 | 41,289 | |||||
| Property and equipment, net | 1,089 | 884 | |||||
| Deposits and other assets | 7,459 | 8,096 | |||||
| Total assets | $ | 519,009 | $ | 570,540 | |||
| Current liabilities | $ | 70,331 | $ | 111,542 | |||
| Noncurrent liabilities | 230,064 | 233,126 | |||||
| Stockholders’ equity | 218,614 | 225,872 | |||||
| Total liabilities and stockholders' equity | $ | 519,009 | $ | 570,540 | |||
Note 1: Derived from audited financial statements included in the Company’s annual report on Form 10-K for the year ended December 31, 2025.
Investors and Media
Dawn Schottlandt
Senior Vice President, Investor Relations and Corporate Affairs
dschottlandt@geron.com
