Welcome to our dedicated page for Genmab news (Ticker: GMAB), a resource for investors and traders seeking the latest updates and insights on Genmab stock.
Genmab A/S develops antibody medicines for cancer and other serious diseases through therapeutic formats that include bispecific antibodies, antibody-drug conjugates, immune-modulating antibodies and other next-generation modalities. Company news commonly centers on clinical data, regulatory interactions and portfolio decisions for programs such as EPKINLY®/epcoritamab, rinatabart sesutecan (Rina-S®) and petosemtamab.
Recurring updates also cover collaborations and commercialization economics tied to antibody products, including DARZALEX® royalties under the Johnson & Johnson license, EPKINLY development with AbbVie, research partnerships, and capital or shareholder announcements. Genmab’s disclosures frequently connect pipeline progress with hematologic malignancies, solid tumors and the company’s broader antibody-technology strategy.
AbbVie and Genmab announced the publication of results from the dose escalation part of the Phase 1/2 EPCORE NHL-1 trial for epcoritamab, an investigational therapy targeting relapsed/refractory B-cell non-Hodgkin's lymphoma. The trial identified a recommended Phase 2 dose of 48mg with an overall response rate of 88% and a complete response rate of 38% in patients with DLBCL. Epcoritamab demonstrated a favorable safety profile, with common adverse events being primarily grade 1-2. The results underline significant interest in new treatment options for patients with hematologic malignancies.
Genmab A/S (Nasdaq: GMAB) and Bolt Biotherapeutics, Inc. (Nasdaq: BOLT) announced a collaboration for oncology research and development. The partnership aims to combine Genmab's antibody technologies with Bolt's Boltbody™ immune-stimulating antibody conjugate platform to develop novel cancer treatments. Genmab will invest USD 10 million upfront and USD 15 million in equity into Bolt, with potential milestone payments of up to USD 285 million per therapeutic candidate. The collaboration will evaluate multiple bispecific antibody concepts.
Genmab A/S (Nasdaq: GMAB) and Seagen Inc. (Nasdaq: SGEN) announced the FDA's acceptance of their Biologics License Application (BLA) for tisotumab vedotin, targeting recurrent or metastatic cervical cancer. This application, filed in February 2021, is under Priority Review, with a decision expected by October 10, 2021. The BLA is based on the innovaTV 204 trial results, highlighting the need for new therapies in a field with low response rates. Both companies aim to enhance treatment options for patients with this severe condition.
Seagen and Genmab submitted a Biologics License Application (BLA) to the FDA for tisotumab vedotin, aimed at treating recurrent or metastatic cervical cancer following chemotherapy. The BLA is based on the innovaTV 204 phase 2 clinical trial, which showed durable responses and a manageable safety profile in patients. Approximately 13,500 women are diagnosed with invasive cervical cancer annually in the U.S., highlighting the need for effective therapies. This milestone could significantly benefit patients with high unmet medical needs.