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Genenta Science (Nasdaq: GNTA) announced its upcoming presentation at the 'Montalcini Global Biotech Tour' in Doha, Qatar on April 17th, 2025. The presentation follows two significant financial developments:
1. A €20 million ($22.7 million) strategic financing through a Mandatory Convertible Bond to ENEA Tech and Biomedical (ETB), aimed at advancing Temferon™ in metastatic Renal Cell Cancer (mRCC)
2. An additional €3.0 million ($3.2 million) raised via an at-the-market (ATM) facility
The event will be hosted by Qatar's Minister of State for Foreign Trade Affairs and Italy's Minister of Health, featuring presentations from key stakeholders including Qatar Research, Development and Innovation Council (QRDI) and potential meetings with Qatar Investment Authority (QIA), which manages over $475 billion in assets.
Genenta Science (GNTA) has secured a €20 million ($21.9M) financing through a Mandatory Convertible Bond from ENEA Tech and Biomedical (ETB) to expand its pipeline. The funding will support advancing Temferon in metastatic Renal Cell Cancer (mRCC).
The bond structure includes a first tranche of €7.5M for safety assessment in the mRCC trial, and a second tranche of €12.5M conditional upon achieving safety milestones. The bond matures in March 2028 with a two-year lock-up period, and ETB's equity will be capped at 29% with a maximum conversion price of $17.64 per share.
Recent data from the Phase 1/2a Glioblastoma Multiforme (GBM) uMGMT trial shows promising results with 29% patient survival at two years (up from 25% in October) and 17 months median overall survival, compared to historical data of 14% two-year survival and 13-15 months median survival with standard care.
The Italian Trade Agency (ITA) hosted the eighth edition of 'Italy on the Move' during the 43rd J.P. Morgan Healthcare Conference 2025, attracting over 230 executives and investors. The event highlighted investment opportunities in Italy's €270 Billion life sciences sector. Director General Mauro Battocchi presented Italy's achievements, including €2 billion in pharma R&D investments in 2023 and an average life expectancy of 83.8 years.
The event featured a panel discussion titled 'Navigating Transatlantic Partnerships in Life Sciences,' moderated by Audrey Greenberg, with participation from prominent executives including leaders from Rubedo Life Sciences, Bracco Imaging, Menarini Group, TPG Capital, Genenta Science, ENEA Tech and Biomedical, and DOC Pharma. Five Italian startups also pitched their innovations: Aavantgarde, Butterfly Decisions, Cellply, Medlea, and Sibylla Biotech.
Italy on the Move, a side event of the 43rd annual J.P. Morgan Healthcare Conference 2025, will showcase Italy as a leading competitive hub for investments in biotech, healthcare, medical devices, and pharmaceuticals. The event, hosted by The Italian Trade Agency and the Ministry of Foreign Affairs, will take place on January 15th, 2025, at INNOVIT in San Francisco.
The event will feature notable speakers including Italian Ambassador H.E. Mariangela Zappia and include a panel discussion on Transatlantic Partnerships in Life Sciences. Five Italian startups - Aavantgarde, Butterfly Decisions, Cellply, Medlea, and Sibylla Biotech - will present pitch presentations. The event highlights Italy's €270 Billion life sciences sector and aims to foster innovation and collaboration between Italian and American stakeholders.
Genenta Science (NASDAQ: GNTA) has enhanced its partnership with AGC Biologics by securing an exclusive GMP manufacturing suite at AGC's Cell and Gene Center of Excellence in Milan. This strategic amendment aims to strengthen the production of Genenta's cell therapy products, ensuring cGMP compliance.
The company's metastatic Renal Cell Cancer (mRCC) Phase 1/2a trial, initiated in Q4 2024, aims to treat six patients by H1 2025, while the Glioblastoma Multiforme (GBM) study continues. Genenta plans to manufacture 27 autologous drug products in 2025.
Recent preclinical and clinical studies highlight Temferon's capability to reprogram the tumor microenvironment, inhibit myeloid cell-induced immune suppression, and enhance T-cell responses. The company suggests potential synergies with immunotherapeutic strategies, including immune checkpoint inhibitors and CAR-T cell therapies.
The Italian Trade Agency (ITA) and the Ministry of Foreign Affairs will host the eighth 'Italy on the Move' event alongside the 43rd J.P. Morgan Healthcare Conference 2025 in San Francisco. The event, scheduled for January 15, 2025, at INNOVIT, aims to showcase Italy's €270 billion life sciences sector and investment opportunities.
The Italian life sciences ecosystem, contributing 11% to the country's GDP, has attracted nearly 50 multinational companies. Italy ranks first among EU economies in pharma CDMO manufacturing value and fourth worldwide in Life Sciences patents productivity.
The event will feature keynote speakers including Ambassador Mariangela Zappia and Director General Mauro Battocchi, followed by a panel discussion on 'Navigating Transatlantic Partnerships in Life Sciences' moderated by Audrey Greenberg. Notable panelists include executives from Rubedo Life Sciences, Bracco Imaging, Menarini Group, TPG Capital, and Genenta Science (NASDAQ: GNTA). Five Italian startups - Aavantgarde, Butterfly Decisions, Cellply, Medlea, and Sibylla Biotech - will present pitch presentations.
Genenta Science (NASDAQ: GNTA) announces CEO Pierluigi Paracchi's participation as a speaker at the Italy-U.S. meeting on 'Cross-Border Investments and Strategies in the Biotechnology Sector: A Transatlantic Perspective' at the U.S. Senate on October 25th, 2024. The event, organized by the U.S. National Security Commission on Emerging Biotechnology and Italian Embassy, features distinguished speakers including Michelle Rozo, Mariangela Zappia, and Patrick Soon-Shiong.
As moderator of the Italian Working Group on Internationalization of Biotech Sector (NWTIB), Paracchi will present the Interim Report, emphasizing the strategic importance of biotechnologies post-pandemic and Italy's role in preserving and advancing these innovations while attracting international investments.
Genenta Science (NASDAQ: GNTA) has received approval from AIFA for a new Phase 1 clinical trial for metastatic Renal Cell Cancer (mRCC), expanding potential applications for its flagship product, Temferon™. This approval aligns with EMA standards. The company's ongoing TEM-GBM development program has completed a Phase 1 dose-ranging trial, confirming no dose-limiting toxicities across 24 patients. Temferon-derived cells remained detectable for over two years post-infusion, with treatment associated with a median survival of 16.8 months and a 25% increase in 2-year overall survival.
The new mRCC trial, targeting high-risk patients with a median overall survival of less than 2 years after multiple therapies, is expected to start in Q4 2024. Recent preclinical studies show synergy between Temferon and other immunotherapies in solid tumors. Genenta will present these developments at upcoming events, including Maxim Group's 2024 Healthcare Virtual Summit and the Society for Neuro-Oncology Annual Meeting.
Genenta Science (NASDAQ: GNTA) recently appointed five new directors to its Board of Directors, including John L. Cantello, Lauren H. Chung, Armon R. Sharei, and Todd Wider. The company aims to leverage the expertise of these new members to further develop its cell-based platform for treating solid tumors. The shareholders' meeting held on May 2, 2024, marked a significant step towards strengthening the company's leadership and strategic direction.
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