Hepion Pharmaceuticals Inc Stock Price, News & Analysis

Hepion Pharmaceuticals (NASDAQ:HEPA) announced its collaboration with London's Institute of Hepatology to present new findings on rencofilstat at the ISBRA and ESBRA joint meeting in Cracow, Poland, from September 17-20, 2022. The study highlights rencofilstat's effectiveness against Alcohol-associated Liver Disease (ALD) by targeting cyclophilins, which are implicated in liver damage. Results showed significant reductions in fibrosis markers and improved cytokine profiles in liver tissue models. CEO Dr. Robert Foster emphasized rencofilstat's potential in treating ALD-induced fibrosis.

Hepion Pharmaceuticals has initiated a Phase 2 clinical trial for rencofilstat, targeting non-alcoholic steatohepatitis (NASH). The ALTITUDE-NASH study will assess 60 adult subjects over four months, with doses of 75, 150, or 225 mg. The trial's goal is to evaluate hepatic function using HepQuant's SHUNT test and other NASH biomarkers. This collaboration with HepQuant and Summit Clinical Research highlights the pressing need for effective NASH treatments, as the disease poses significant health risks without FDA-approved therapies.

Hepion Pharmaceuticals, Inc. (NASDAQ:HEPA) will participate in the H.C. Wainwright 24th Annual Global Investment Conference, with a pre-recorded presentation available on demand for attendees from September 12, 2022. The company is focused on developing rencofilstat, an AI-driven therapeutic for chronic liver diseases, including non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Rencofilstat has received FDA Fast Track and Orphan Drug designations, demonstrating its potential in addressing liver disease and improving patient outcomes.

Hepion Pharmaceuticals has announced the screening of the first subject in its ASCEND-NASH clinical trial, aimed at studying rencofilstat for treating non-alcoholic steatohepatitis (NASH). The Phase 2b trial will involve 336 subjects over one year, focusing on F2/F3 fibrosis levels, with a target for 60% F3 subjects. Rencofilstat aims to improve fibrosis and steatosis scores. The trial will also employ AI-POWR™ technology to identify patients likely to respond positively. Hepion received FDA Fast Track designation for rencofilstat in November 2021, facilitating smoother transitions through clinical phases.

Hepion Pharmaceuticals (NASDAQ:HEPA) has announced the adjournment of its 2022 annual meeting to August 5, 2022, at 9:00 a.m. ET regarding Proposal 4 for an authorized share increase. The record date for voting remains April 26, 2022. Proxies representing about 60% of shares have been submitted, allowing for a quorum. The Board believes that approving this proposal will provide flexibility for future financings and other purposes. Shareholders are encouraged to vote by August 4, 2022, at 11:59 p.m. ET.

Hepion Pharmaceuticals, Inc. (NASDAQ:HEPA) has appointed Anand Reddi and Kaouthar Lbiati to its Board of Directors. Reddi brings extensive experience in corporate strategy and drug development, while Lbiati has a strong background in global health policy and oncology. These appointments come as Hepion prepares to advance its lead drug candidate, rencofilstat, into three Phase 2 clinical trials, targeting NASH and hepatocellular carcinoma. Hepion has previously received FDA Fast Track and Orphan Drug designations for rencofilstat, highlighting its potential in treating these chronic diseases.

Hepion Pharmaceuticals (NASDAQ:HEPA) has adjourned its 2022 annual meeting to July 22, 2022, mainly concerning Proposal 4 (Authorized Share Increase). Votes representing about 60% of outstanding shares constituted a quorum. While elections for directors and the appointment of independent auditors passed, Proposals 3 (2022 Omnibus Equity Incentive Plan), 4 (Authorized Share Increase), and 5 (Say-On-Pay) did not receive sufficient support. The Board urges stockholders to vote for Proposal 4, emphasizing the necessity for additional shares for corporate flexibility, including future financings and acquisitions.

Hepion Pharmaceuticals (NASDAQ:HEPA) announced FDA's Orphan Drug Designation for its drug rencofilstat, aimed at treating hepatocellular carcinoma (HCC). This designation highlights its potential to address significant unmet medical needs in an aggressive cancer type, which accounts for 85-90% of liver cancer cases. Hepion plans to initiate a Phase 2a study of rencofilstat in HCC in Q3 2022, alongside ongoing Phase 2 studies for non-alcoholic steatohepatitis (NASH). The Orphan Drug Designation offers various incentives, including potential seven-year market exclusivity and tax credits for clinical trials.

Hepion Pharmaceuticals, Inc. (NASDAQ:HEPA) announced that five abstracts were accepted for poster presentations at the European Association for the Study of the Liver (EASL) International Liver Congress™ 2022, held from June 22 to 26, 2022, in London. These presentations focus on rencofilstat, a cyclophilin inhibitor in clinical development for non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Key topics include its anti-tumor activities and anti-fibrotic effects demonstrated in clinical trials.