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Hoth Therapeutics Secures Japanese Patent for Breakthrough HT-KIT Platform Targeting Mast Cell Diseases

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Hoth Therapeutics (NASDAQ: HOTH) has secured Japanese Patent No. 7677628 for its HT-KIT platform technology, providing protection until August 27, 2039. The patent, titled "Targeting KIT with Splice Switching Oligonucleotides to Induce Apoptosis of Mast Cells," covers their innovative approach using splice-switching oligonucleotides to disrupt KIT gene expression in mast cells. This technology targets conditions ranging from chronic hives to rare cancers. CEO Robb Knie highlighted the strategic importance of securing IP protection in Japan's pharmaceutical market, indicating potential licensing opportunities across Asia. The company is actively seeking strategic global partners for co-development and commercialization of the HT-KIT platform.
Hoth Therapeutics (NASDAQ: HOTH) ha ottenuto il brevetto giapponese n. 7677628 per la sua tecnologia piattaforma HT-KIT, garantendo protezione fino al 27 agosto 2039. Il brevetto, intitolato "Targeting KIT con oligonucleotidi splice-switching per indurre l'apoptosi delle cellule mastocitarie", riguarda il loro approccio innovativo che utilizza oligonucleotidi splice-switching per interrompere l'espressione del gene KIT nelle cellule mastocitarie. Questa tecnologia è rivolta a condizioni che vanno dall'orticaria cronica a tumori rari. Il CEO Robb Knie ha sottolineato l'importanza strategica di ottenere la protezione della proprietà intellettuale nel mercato farmaceutico giapponese, indicando potenziali opportunità di licenza in tutta l'Asia. L'azienda è attivamente alla ricerca di partner strategici globali per lo sviluppo congiunto e la commercializzazione della piattaforma HT-KIT.
Hoth Therapeutics (NASDAQ: HOTH) ha obtenido la patente japonesa Nº 7677628 para su tecnología de plataforma HT-KIT, asegurando protección hasta el 27 de agosto de 2039. La patente, titulada "Dirigiendo KIT con oligonucleótidos de cambio de empalme para inducir la apoptosis de las células mastocíticas", cubre su enfoque innovador que utiliza oligonucleótidos de cambio de empalme para interrumpir la expresión del gen KIT en las células mastocíticas. Esta tecnología está dirigida a condiciones que van desde la urticaria crónica hasta cánceres raros. El CEO Robb Knie destacó la importancia estratégica de asegurar la protección de la propiedad intelectual en el mercado farmacéutico japonés, señalando oportunidades potenciales de licenciamiento en toda Asia. La compañía está buscando activamente socios estratégicos globales para el co-desarrollo y la comercialización de la plataforma HT-KIT.
Hoth Therapeutics(NASDAQ: HOTH)는 HT-KIT 플랫폼 기술에 대해 일본 특허 번호 7677628을 확보하여 2039년 8월 27일까지 보호를 받게 되었습니다. "스플라이스 스위칭 올리고뉴클레오티드를 이용한 KIT 표적화로 비만 세포의 세포자멸사를 유도하는 기술"이라는 제목의 이 특허는 비만 세포에서 KIT 유전자 발현을 방해하는 혁신적인 스플라이스 스위칭 올리고뉴클레오티드 접근법을 포함합니다. 이 기술은 만성 두드러기부터 희귀 암에 이르는 다양한 질환을 대상으로 합니다. CEO Robb Knie는 일본 제약 시장에서 지적 재산권 보호 확보의 전략적 중요성을 강조하며 아시아 전역에서 라이선스 기회가 있을 것임을 언급했습니다. 회사는 HT-KIT 플랫폼의 공동 개발 및 상용화를 위한 글로벌 전략적 파트너를 적극적으로 찾고 있습니다.
Hoth Therapeutics (NASDAQ : HOTH) a obtenu le brevet japonais n° 7677628 pour sa technologie de plateforme HT-KIT, assurant une protection jusqu'au 27 août 2039. Le brevet, intitulé « Ciblage de KIT avec des oligonucléotides de commutation d'épissage pour induire l'apoptose des mastocytes », couvre leur approche innovante utilisant des oligonucléotides de commutation d'épissage pour perturber l'expression du gène KIT dans les mastocytes. Cette technologie cible des conditions allant de l'urticaire chronique à des cancers rares. Le PDG Robb Knie a souligné l'importance stratégique de sécuriser la protection de la propriété intellectuelle sur le marché pharmaceutique japonais, indiquant des opportunités potentielles de licence à travers l'Asie. La société recherche activement des partenaires mondiaux stratégiques pour le co-développement et la commercialisation de la plateforme HT-KIT.
Hoth Therapeutics (NASDAQ: HOTH) hat das japanische Patent Nr. 7677628 für seine HT-KIT Plattformtechnologie erhalten, die Schutz bis zum 27. August 2039 bietet. Das Patent mit dem Titel "Targeting KIT mit Spleißwechsel-Oligonukleotiden zur Induktion der Apoptose von Mastzellen" umfasst ihren innovativen Ansatz, Spleißwechsel-Oligonukleotide zu verwenden, um die Expression des KIT-Gens in Mastzellen zu stören. Diese Technologie richtet sich gegen Erkrankungen von chronischer Nesselsucht bis hin zu seltenen Krebsarten. CEO Robb Knie betonte die strategische Bedeutung des Schutzes geistigen Eigentums auf dem japanischen Pharmamarkt und verwies auf potenzielle Lizenzierungsmöglichkeiten in ganz Asien. Das Unternehmen sucht aktiv nach strategischen globalen Partnern für die gemeinsame Entwicklung und Vermarktung der HT-KIT Plattform.
Positive
  • Patent protection secured in Japan's significant pharmaceutical market until 2039
  • Technology has broad application potential across mast cell-driven inflammatory and oncologic conditions
  • Positioned for orphan drug designations and expedited regulatory pathways
  • Strategic licensing opportunities available across Asian markets
Negative
  • None.

Protection through 2039, ensuring long-term commercial exclusivity.

NEW YORK, June 12, 2025 /PRNewswire/ -- Hoth Therapeutics, Inc. (NASDAQ: HOTH), a clinical-stage biopharmaceutical company developing innovative therapies, today announced that they have obtained Japan Country Patent No. 7677628 for the HT-KIT platform. The patent was officially granted by the Japan Patent Office on May 7, 2025, and exclusive protection is granted until August 27, 2039.

The granted patent, titled "Targeting KIT with Splice Switching Oligonucleotides to Induce Apoptosis of Mast Cells," protects Hoth's novel approach of using splice-switching oligonucleotides (SSOs) to selectively disrupt KIT gene expression in mast cells—cells implicated in conditions ranging from chronic hives to rare cancers.

"Securing intellectual property protection in Japan—a globally significant pharmaceutical market—underscores the global value of HT-KIT," said Robb Knie, CEO of Hoth Therapeutics. "We see strategic licensing potential across Asia as we move this asset forward."

Key Highlights

  • Patent No. 7677628, granted by Japan Patent Office.
  • Protection through 2039, ensuring long-term commercial exclusivity.
  • Applicable to mast cell-driven inflammatory and oncologic conditions.
  • Positioned for orphan indications and expedited regulatory pathways.

HT-KIT is one of several novel platforms under development at Hoth Therapeutics, which continues to seek strategic global partners, particularly in Asia, for co-development and commercialization opportunities.

To learn more, visit: www.hoththerapeutics.com

About Hoth Therapeutics, Inc.
Hoth Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing innovative, impactful, and ground-breaking treatments with a goal to improve patient quality of life. We are a catalyst in early-stage pharmaceutical research and development, elevating drugs from the bench to pre-clinical and clinical testing. Utilizing a patient-centric approach, we collaborate and partner with a team of scientists, clinicians, and key opinion leaders to seek out and investigate therapeutics that hold immense potential to create breakthroughs and diversify treatment options. To learn more, please visit https://ir.hoththerapeutics.com/.

Forward-Looking Statement
This press release includes forward-looking statements based upon Hoth's current expectations, which may constitute forward-looking statements for the purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995 and other federal securities laws, and are subject to substantial risks, uncertainties, and assumptions. These statements concern Hoth's business strategies; the timing of regulatory submissions; the ability to obtain and maintain regulatory approval of existing product candidates and any other product candidates we may develop, and the labeling under any approval we may obtain; the timing and costs of clinical trials, and the timing and costs of other expenses; market acceptance of our products; the ultimate impact of any health epidemic, on our business, our clinical trials, our research programs, healthcare systems, or the global economy as a whole; our intellectual property; our reliance on third-party organizations; our competitive position; our industry environment; our anticipated financial and operating results, including anticipated sources of revenues; our assumptions regarding the size of the available market, benefits of our products, product pricing, and timing of product launches; management's expectation with respect to future acquisitions; statements regarding our goals, intentions, plans, and expectations, including the introduction of new products and markets; and our cash needs and financing plans. There are a number of factors that could cause actual events to differ materially from those indicated by such forward-looking statements. You should not place reliance on these forward-looking statements, which include words such as "could," "believe," "anticipate," "intend," "estimate," "expect," "may," "continue," "predict," "potential," "project" or similar terms, variations of such terms, or the negative of those terms. Although the company believes that the expectations reflected in the forward-looking statements are reasonable, the company cannot guarantee such outcomes. Hoth may not realize its expectations, and its beliefs may not prove correct. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, including, without limitation, market conditions and the factors described in the section titled "Risk Factors" in Hoth's most recent Annual Report on Form 10-K and Hoth's other filings made with the U. S. Securities and Exchange Commission. All such statements speak only as of the date made. Consequently, forward-looking statements should be regarded solely as Hoth's current plans, estimates, and beliefs. Investors should not place undue reliance on forward-looking statements. Hoth cannot guarantee future results, events, levels of activity, performance, or achievements. Hoth does not undertake and specifically declines any obligation to update, republish, or revise any forward-looking statements to reflect new information, future events, or circumstances or to reflect the occurrences of unanticipated events, except as may be required by applicable law.

Investor Contact:
LR Advisors LLC 
Email: investorrelations@hoththerapeutics.com
www.hoththerapeutics.com
Phone: (678) 570-6791

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SOURCE Hoth Therapeutics, Inc.

FAQ

What is the significance of HOTH's new Japanese patent for HT-KIT?

The patent (No. 7677628) provides exclusive protection in Japan until 2039 for HOTH's technology targeting mast cell diseases, securing their position in a major pharmaceutical market.

How does Hoth Therapeutics' HT-KIT technology work?

HT-KIT uses splice-switching oligonucleotides (SSOs) to selectively disrupt KIT gene expression in mast cells, targeting conditions from chronic hives to rare cancers.

When does HOTH's Japanese patent for HT-KIT expire?

The patent provides protection until August 27, 2039.

What are the potential applications for HOTH's HT-KIT platform?

The platform targets mast cell-driven inflammatory and oncologic conditions, with potential for orphan indications and expedited regulatory pathways.

What are Hoth Therapeutics' plans for HT-KIT in Asia?

The company is actively seeking strategic partners across Asia for co-development and commercialization opportunities.
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