IDEAYA Biosciences Announces ESMO 2026 Presentations for Darovasertib and IDE849 Clinical Programs
Rhea-AI Summary
IDEAYA Biosciences (Nasdaq: IDYA) announced that three darovasertib abstracts and one IDE849 abstract have been accepted for poster presentation at the ESMO 2026 Congress, to be held October 23–27, 2026, in Madrid, Spain.
The company will present data updates from multiple ongoing uveal melanoma trials, including the registrational Phase 2/3 OptimUM-02 study in HLA*A2:01‑negative metastatic uveal melanoma, the Phase 2 OptimUM-01 study in HLA*A2:01‑positive metastatic uveal melanoma, and the Phase 2 OptimUM-09 neoadjuvant study in primary uveal melanoma. IDEAYA’s partner Hengrui Pharma will present long‑term results from a Phase 1 study of IDE849 (SHR‑4849), a DLL3‑targeting TOP1 antibody‑drug conjugate, in relapsed small cell lung carcinoma and other neuroendocrine carcinomas. Named academic investigators from Australia, France, the United States, and China are listed as presenting authors for each poster.
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Key Figures
Historical Context
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Jun 26 | Equity compensation grants | Neutral | +1.2% | Announcement of stock option inducement grants to newly hired employees. |
| Jun 17 | Leadership change | Positive | +2.3% | Board elects Yujiro S. Hata as Chairman alongside existing CEO role. |
| Jun 15 | Clinical trial initiation | Positive | +4.3% | First patient enrolled in Phase 1/2 IDE892 and IDE397 combo trial. |
| Jun 10 | Equity offering closing | Neutral | +4.5% | Closing of public offering generating approximately $345 million gross proceeds. |
| Jun 08 | Equity offering pricing | Negative | -7.6% | Pricing of $300 million common stock and pre‑funded warrant offering. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Recent IDEAYA headlines, including clinical pipeline updates and financing, have generally seen share price moves that align with the tone of the news.
Key Terms
neoadjuvant medical
registrational medical
adc medical
dll3 medical
hla*a2:01 medical
sclc medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
"We're excited to showcase the breadth of our pipeline progress at this year's ESMO Congress. Additional data from our ongoing trials in both metastatic and neoadjuvant uveal melanoma, namely OptimUM-02, OptimUM-01 and OptimUM-09, bolster our conviction in the potential of darovasertib to become an important new treatment option across the uveal melanoma patient journey. We also hope to highlight the potential best-in-class profile of IDE849, our Phase 1 DLL3 TOP1 ADC, in SCLC and NECs, where monotherapy and combination trials are ongoing and the program's first registrational trial is targeted to initiate by year-end by partner Hengrui in
IDEAYA Presentations:
2092P (Poster Presentation); Neoadjuvant Darovasertib in Primary Uveal Melanoma: Follow-Up Data from the Phase 2 OptimUM-09 Study. Presenting Author - Mark Shackleton, MBBS, PhD, FRACP, Department of Oncology, Alfred Hospital, and Department of Cancer Medicine, Monash University,
2104P (Poster Presentation); Darovasertib with Crizotinib vs Investigator's Choice as First-Line Treatment for Patients with HLA-A2 Negative Metastatic Uveal Melanoma (OptimUM-02): A Subgroup Analysis. Presenting Author - Sophie Piperno-Neumann, MD, PhD, Institute Curie Research University,
2086P (Poster Presentation); Darovasertib and Crizotinib for HLA-A*02–Positive Metastatic Uveal Melanoma: Results from the Phase 2 OptimUM-01 Study. Presenting Author - Meredith McKean, MD, MPH, Sarah Cannon Research Institute,
Hengrui Presentation:
3815P (Poster Presentation); SHR-4849 (IDE849), an ADC targeting delta-like ligand 3 (DLL3), in relapsed small cell lung carcinoma (SCLC) and other neuroendocrine carcinomas (NECs): long-term results from the Phase 1 study. Presenting Author – Haifeng Liu, PhD, Professor, Clinical Research Ward, Jilin Cancer Hospital,
About IDEAYA Biosciences
IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies to address unmet medical needs in cancer. The company integrates small-molecule drug discovery, structural biology and bioinformatics with extensive capabilities in identifying and validating translational biomarkers to develop potentially first-in-class targeted therapies for selected patient populations. IDEAYA has built a robust pipeline of targeted therapies focused on synthetic lethality and antibody-drug conjugates, or ADCs, including bispecifics, with the goal of improving clinical outcomes for patients with cancer.
Forward-Looking Statements
This press release contains forward-looking statements, within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements related to IDEAYA's expectations, beliefs and plans regarding its clinical development programs, including the potential therapeutic benefits, clinical profile, and differentiating characteristics of darovasertib, IDE849, IDE892 and IDE397; the timing conduct and anticipated results of ongoing and planned clinical trials, including anticipated initiation of registrational trials; the potential of darovasertib to become an important new treatment option across the uveal melanoma treatment paradigm; the potential best-in-class profile of IDE849; the anticipated future growth of IDEAYA's pipeline and portfolio; the expected presentation and content of clinical data at the 2026 ESMO Congress; the activities and expected performance of IDEAYA's collaboration partners, including Hengrui Pharma; and the potential of IDEAYA's product candidates to address unmet medical needs. Such forward-looking statements are based on management's current expectations, assumptions and beliefs and involve substantial risks and uncertainties that could cause actual results, including, but not limited to, those related to IDEAYA's clinical programs, regulatory activities, commercial activities, and performance and/or achievements, to differ significantly and/or materially from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the drug development process, including the process of designing and conducting preclinical and clinical trials; patient enrollment rates and retention; biomarker identification, patient selection and diagnostic testing; safety, tolerability, and efficacy results; regulatory interactions and decisions; the ability to translate preclinical findings into clinical benefit; manufacturing and supply risks; competition and changes in standard of care; the timing and success of commercialization efforts; the performance of IDEAYA's collaboration partners, including their ability to conduct clinical development activities and achieve anticipated development and regulatory milestones; the outcome of collaborations and licensing arrangements; IDEAYA's ability to successfully establish, protect and defend its intellectual property; and other matters that could affect the sufficiency of financial resources to fund operations. IDEAYA undertakes no obligation to update or revise any forward-looking statements. A further description of risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of IDEAYA in general, are in IDEAYA's filings with the Securities and Exchange Commission, including IDEAYA's most recent Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q and current Reports on Form 8-K.
Investor and Media Contact
IDEAYA Biosciences
Joshua Bleharski, Ph.D.
Chief Financial Officer
investor@ideayabio.com
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SOURCE IDEAYA Biosciences, Inc.