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Immutep Announces Abstract Accepted for Presentation at the European Society for Medical Oncology (ESMO) Congress 2026

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Immutep (NASDAQ: IMMP) announced that an abstract from the investigator-initiated Phase II EFTISARC-NEO trial of its MHC Class II agonist eftilagimod alfa (efti) in soft tissue sarcoma has been accepted as an ePoster for the ESMO Congress 2026, held 23–27 October 2026 in Madrid, Spain.

The abstract focuses on health-related quality of life (HRQoL) during neoadjuvant treatment with efti, pembrolizumab and radiotherapy. It will be available online on the ESMO website from 00:05 CEST on 19 October 2026 (Presentation #3788eP), with the presentation later accessible on Immutep’s website. The first author is Dr. Pawel Teterycz from the Maria Skłodowska-Curie National Research Institute of Oncology in Warsaw.

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Positive

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Negative

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News Market Reaction – IMMP

-2.01%
-2.01% News Effect

On the day this news was published, IMMP declined 2.01%, reflecting a moderate negative market reaction.

Data tracked by StockTitan Argus on the day of publication.

Market Context

Historical results included both alignment and divergence, including event 1081367 at -3.93%. For th...
Analysis

Historical results included both alignment and divergence, including event 1081367 at -3.93%. For this announcement, the platform record emphasizes monitoring the forthcoming abstract content rather than the acceptance alone.

Key Figures

Trial Phase: Phase II Trial Identifier: NCT06128863 Congress Dates: 23–27 October 2026 +2 more
5 metrics
Trial Phase Phase II EFTISARC-NEO investigator-initiated trial
Trial Identifier NCT06128863 EFTISARC-NEO
Congress Dates 23–27 October 2026 ESMO Congress 2026 in Madrid
Abstract Publication 19 October 2026 at 00:05 CEST ESMO Congress website
Presentation Number 3788eP ESMO ePoster

Historical Context

5 past events · Latest: Jul 14 (Positive)
Pattern 5 events
Date Event Sentiment 24h Move Catalyst
Jul 14 Patent announcement Positive -3.9% Fourth U.S. patent expanded protection for eftilagimod alfa combination methods
Jul 13 Clinical update Negative +7.5% Positive survival data accompanied disclosure of TACTI-004 discontinuation
Jun 04 Phase I clinical data Positive -4.5% IMP761 showed safety and statistically significant pharmacodynamic activity
May 28 Clinical data release Positive +2.3% Pooled data linked immune activation with improved overall survival
Apr 30 Quarterly activities report Negative -3.2% TACTI-004 discontinuation and increased loss were disclosed

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Pattern Detected

Recent news reactions were mixed, with positive clinical or intellectual-property updates sometimes followed by negative price reactions.

Key Terms

hrqol, mhc class ii agonist, lag-3, soft tissue sarcoma
4 terms
hrqol medical
"The abstract reports health-related quality of life (HRQoL) data"
Health-related quality of life (HRQoL) is a measure of how a person’s health condition and its treatment affect their daily functioning, symptoms, emotional well-being, and ability to do normal activities. For investors, HRQoL data matter because regulators, payers, and doctors often use these measures—alongside clinical outcomes—to judge a therapy’s real-world value, market acceptance, and potential reimbursement, similar to how customer satisfaction shapes demand for a product.
mhc class ii agonist medical
"a first-in-class MHC Class II agonist, eftilagimod alfa"
A MHC class II agonist is a molecule that binds to and stimulates major histocompatibility complex class II proteins, which present pieces of foreign or internal proteins to helper T cells in the immune system. Think of it as a tool that boosts the ‘display and call-to-action’ function on immune cells so helper T cells recognize and respond to targets; for investors, it signals a specific immune-modulating mechanism relevant to vaccines and certain immunotherapies, with implications for effectiveness and safety.
lag-3 medical
"therapeutics related to Lymphocyte Activation Gene-3 (LAG-3)"
A protein found on certain immune cells that acts like a brake, helping control how aggressively the immune system attacks threats such as cancer. Drugs that block or modify LAG-3 can release that brake, potentially enabling stronger anti‑cancer responses; because such treatments can change patient outcomes and open new markets, LAG-3-related data, approvals, or setbacks often have big effects on a biotech or pharmaceutical company’s valuation.
soft tissue sarcoma medical
"patients with soft tissue sarcoma (STS)"
A soft tissue sarcoma is a type of cancer that starts in the body’s soft tissues — such as muscles, fat, nerves, blood vessels or connective tissue — rather than in organs or bones. For investors, it matters because treatments for these cancers drive drug development, clinical trial results and regulatory decisions; a successful therapy can create a meaningful commercial market while trial failures or safety issues can affect a company’s valuation and prospects.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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SYDNEY, AUSTRALIA, July 24, 2026 (GLOBE NEWSWIRE) -- Immutep Limited (ASX: IMM; NASDAQ: IMMP) (“Immutep” or “the Company”), a late-stage immunotherapy company targeting cancer and autoimmune diseases, today announced that an abstract for the investigator-initiated EFTISARC-NEO Phase II trial evaluating its first-in-class MHC Class II agonist, eftilagimod alfa (“efti”), has been accepted for presentation at the European Society for Medical Oncology (ESMO) Congress 2026, taking place 23–27 October 2026 in Madrid, Spain.

The abstract reports health-related quality of life (HRQoL) data from EFTISARC-NEO. Details of the accepted abstract and poster are as follows:

TitleHealth-related quality of life (HRQoL) during neoadjuvant treatment with eftilagimod alfa, pembrolizumab and radiotherapy in patients with soft tissue sarcoma (STS) – results from EFTISARC-NEO trial
TrialEFTISARC-NEO (investigator-initiated Phase II; NCT06128863)
Session categoryePoster
First AuthorPawel Teterycz, M.D., Maria Skłodowska-Curie National Research Institute of Oncology (MSCNRIO), Warsaw, Poland
Presentation #3788eP
Abstract onlineMonday, 19 October 2026 at 00:05 CEST (ESMO website)


The full abstract will be published on the ESMO Congress 2026 website on Monday, 19 October 2026. The presentation will subsequently be made available on Immutep’s website.

About Immutep
Immutep is a late-stage biotechnology company developing novel immunotherapies for cancer and autoimmune disease. The Company is a pioneer in the understanding and advancement of therapeutics related to Lymphocyte Activation Gene-3 (LAG-3), and its diversified product portfolio harnesses LAG-3’s ability to stimulate or suppress the immune response. Immutep is dedicated to leveraging its expertise to bring innovative treatment options to patients in need and to maximise value for shareholders. For more information, please visit www.immutep.com.

Forward-Looking Statements 
This press release contains forward-looking statements, including statements regarding anticipated clinical development, regulatory progress and potential benefits of eftilagimod alfa. These forward-looking statements are based on current expectations, estimates and projections, and involve known and unknown risks, uncertainties and other important factors that could cause actual results to differ materially from those expressed or implied in such statements. 

Factors that could cause actual results to differ materially include risks associated with clinical trial outcomes, regulatory developments, and the Company’s ability to advance its product candidates. 

Readers are cautioned not to place undue reliance on forward-looking statements, which speak only as of the date of this release. Immutep undertakes no obligation to update or revise such statements, except as required by applicable law. 

Disclaimer
This announcement has been prepared for informational purposes only and does not constitute an offer to sell, or a solicitation of an offer to buy, securities in any jurisdiction.

Australian Investors/Media:
Eleanor Pearson, Sodali & Co.
+61 2 9066 4071; eleanor.pearson@sodali.com

US Investors/Media
Matthew Beck, astr partners
+1 (917) 415-1750; matthew.beck@astrpartners.com


FAQ

What did Immutep (NASDAQ: IMMP) announce about the EFTISARC-NEO trial at ESMO 2026?

Immutep announced that an abstract from the Phase II EFTISARC-NEO trial was accepted as an ePoster at ESMO Congress 2026. According to Immutep, the abstract reports health-related quality of life data in soft tissue sarcoma patients receiving neoadjuvant eftilagimod alfa, pembrolizumab and radiotherapy.

When will Immutep’s EFTISARC-NEO abstract for ESMO 2026 be available online?

The EFTISARC-NEO abstract will be published online on the ESMO 2026 website on 19 October 2026 at 00:05 CEST. According to Immutep, the subsequent presentation will later be made available on the company’s website for broader access.

What is the focus of Immutep’s EFTISARC-NEO ePoster at ESMO Congress 2026 (IMMP)?

The ePoster focuses on health-related quality of life during neoadjuvant treatment with eftilagimod alfa, pembrolizumab and radiotherapy in soft tissue sarcoma. According to Immutep, these data come from the investigator-initiated Phase II EFTISARC-NEO trial in patients with soft tissue sarcoma.

What is EFTISARC-NEO and which phase is the Immutep trial presented at ESMO 2026?

EFTISARC-NEO is an investigator-initiated Phase II trial evaluating eftilagimod alfa in soft tissue sarcoma. According to Immutep, the study assesses health-related quality of life during neoadjuvant combination treatment with efti, pembrolizumab and radiotherapy, with results featured as an ePoster at ESMO 2026.

Who is the first author of Immutep’s EFTISARC-NEO abstract at ESMO 2026 and what is the presentation number?

The first author is Dr. Pawel Teterycz from the Maria Skłodowska-Curie National Research Institute of Oncology in Warsaw. According to Immutep, the EFTISARC-NEO ePoster is assigned presentation number 3788eP in the ESMO Congress 2026 program.

Will Immutep make the EFTISARC-NEO ESMO 2026 presentation available to investors and the public?

Yes. Immutep plans to make the EFTISARC-NEO presentation available on its website after the ESMO Congress 2026. According to Immutep, the abstract itself appears first on the ESMO website on 19 October 2026.