Welcome to our dedicated page for Inmune Bio news (Ticker: INMB), a resource for investors and traders seeking the latest updates and insights on Inmune Bio stock.
INmune Bio Inc. (NASDAQ: INMB) is a clinical-stage biotechnology company that regularly issues news and updates about its inflammation and immunology pipeline targeting the innate immune system. This news page aggregates company press releases and third-party coverage related to INmune Bio’s DN-TNF platform, CORDStrom™ mesenchymal stromal cell platform, and INKmune® natural killer cell priming platform.
Readers can find updates on XPro™ (XPro1595, pegipanermin), a selective soluble TNF neutralizer that the company is developing for neurological diseases driven by chronic inflammation. Recent news has highlighted Phase 2 MINDFuL trial results in early Alzheimer’s disease with inflammatory biomarkers, neuroimaging analyses using advanced MRI techniques, and manuscript submissions to peer-reviewed journals. The company also reports on scientific presentations at conferences such as the Clinical Trials on Alzheimer’s Disease (CTAD) meeting and the Alzheimer’s Association International Conference.
News related to the CORDStrom™ cell therapy platform includes clinical and manufacturing milestones in recessive dystrophic epidermolysis bullosa (RDEB), such as completion of a blinded randomized trial, pilot-scale commercial manufacturing runs at a cell and gene therapy manufacturing center in the United Kingdom, and intellectual property developments. INmune Bio also issues updates on participation in industry events and panels focused on dermatologic rare diseases and cell therapy manufacturing.
For the INKmune® platform, news items cover progress in the CaRe PC Phase I/II trial in metastatic castration-resistant prostate cancer, including reports that the trial met its primary and certain secondary endpoints, safety observations, and biomarker findings related to NK cell activation. Corporate news, including financing transactions, management changes, and special stockholder meetings, is also disclosed through regular press releases and corresponding SEC filings. Investors and researchers can use this page to follow INMB news on clinical data, regulatory plans, manufacturing scale-up, and corporate developments.
INmune Bio, Inc. (NASDAQ: INMB) will host a conference call on August 4, 2021, at 4:30 PM ET to discuss its second-quarter results for the period ending June 30, 2021. The call will provide a corporate update, and participants can join by dialing in 5-10 minutes early. A transcript and replay will be available shortly after the call. The company focuses on developing treatments utilizing the innate immune system, with platforms targeting conditions like COVID-19, cancer, Alzheimer’s, and chronic inflammation.
INmune Bio announced the design of a Phase 2 clinical trial of XProTM for mild Alzheimer’s disease (AD), involving 168 patients over six months. The trial aims to assess the impact of reducing neuroinflammation on cognition. Preliminary data from a Phase 1b study indicated improvements in white matter metrics and biomarkers of neuroinflammation with a 1.0 mg/kg dose. A recent $40 million financing will support this Phase 2 trial, which is set to start in Q4 2023, with data expected in 2H2023.
INmune Bio (NASDAQ: INMB) has acquired LUMICKS' z-Movi® Cell Avidity Analyzer to enhance its Natural Killer (NK) Cell Priming Platform, INKmune®. This cutting-edge technology allows INmune to measure the efficacy of NK cells against tumors by analyzing the avidity of cell interactions. Preliminary data suggests that improved NK cell avidity may enhance tumor cell killing. This acquisition aims to streamline potency screening and establish biomarkers, accelerating drug development for cancer therapies.
INmune Bio, Inc. (NASDAQ: INMB) announced plans to commence a Phase 2 study of XPro1595 for Alzheimer’s disease by the end of 2021, following promising Phase 1b results. The upcoming study aims to further evaluate the drug's efficacy in reducing neuroinflammation, which has shown potential in improving biomarkers related to neurodegeneration. The company will present findings at the Alzheimer’s Association International Congress 2021, detailing the positive outcomes from its earlier study.
INmune Bio, Inc. (NASDAQ: INMB) announced a registered direct offering of 1,818,182 shares at $22.00 per share, raising approximately $40 million. The offering, set to close on July 16, 2021, is facilitated by A.G.P./Alliance Global Partners. Proceeds will support working capital, corporate purposes, and advancement of product candidates, particularly the Phase 2 trial of XPro1595 for Alzheimer’s disease, expected to start by year-end 2021. This funding aims to fully support the Alzheimer’s Phase II program.
INmune Bio announces the initiation of its first patient treatment in a Phase 1 clinical trial of INKmune, targeting high-risk myelodysplastic syndrome (MDS). This trial will assess safety, tolerability, and clinical response in MDS patients, a serious condition with no known cure. INKmune aims to enhance the activity of dysfunctional natural killer (NK) cells in patients. Initial findings indicate promising potential for treating MDS and possibly solid tumors. The Phase 1 study will enroll nine patients under a 3x3 dose escalation protocol.
On June 14, 2021, INmune Bio (NASDAQ: INMB) announced a $15 million credit facility with Silicon Valley Bank to fund the buyout of an option held by Xencor, Inc. for $18.3 million. This move eliminates the potential dilution of approximately 2.1 million shares. INmune has made significant progress in developing XPro1595, a treatment for neuroinflammation in conditions like Alzheimer’s. The company is focused on launching Phase 2 trials for XPro1595 later this year, following positive data earlier this year regarding its Alzheimer's application.
INmune Bio (NASDAQ: INMB) has received USAN approval for the generic name Pegipanermin for its lead candidate XPro1595. CEO RJ Tesi stated that this milestone marks the transition from experimental to advanced development, with plans for Phase 2 trials targeting Alzheimer’s disease and Treatment Resistant Depression. The company previously reported positive Phase 1b data showing reduced biomarkers of neuroinflammation in Alzheimer's patients. Pegipanermin utilizes a unique TNF neutralization technology, differentiating it from existing therapies.
INmune Bio (NASDAQ: INMB) announced that CEO RJ Tesi will present at the Alzheimer Disease Panel on May 26, 2021. The event, hosted by M-Vest and presented by Maxim Group LLC, features a panel discussion on advancements in Alzheimer’s drug development, including recent findings about donanemab and the upcoming June 7 PDUFA action date for aducanumab. The panel will include insights from various healthcare experts and companies like Cassava Sciences (SAVA) and Vivoryon Therapeutics (VVY). Join the webinar at 11:00 AM ET for key discussions in the field.
INmune Bio reported its Q1 2021 financial results and provided key business updates. The company is progressing in its Phase I trial of XPro1595 for Alzheimer's disease, showing promising interim results that support a Phase II trial later this year. Additionally, they began screening for a Phase I trial of INKmune for high-risk myelodysplastic syndrome. Financially, INmune raised approximately $29 million through an ATM agreement, but recorded a net loss of $4.6 million for the quarter. The company has $45.3 million in cash with no debt.