INmune Bio Inc. develops clinical-stage immunology and biotechnology treatments designed to target the innate immune system in disease. Company news commonly centers on three platforms: CORDStrom, a pooled allogeneic human umbilical cord-derived mesenchymal stromal/stem cell platform; XPro, a dominant-negative TNF platform intended to selectively neutralize soluble TNF; and INKmune, a cell-based medicine designed to prime natural killer cells against residual cancer.
Recurring updates include clinical and preclinical data, regulatory pathway discussions, manufacturing and collaboration agreements, conference presentations, shareholder communications, and quarterly or annual financial results. Coverage also reflects program areas such as recessive dystrophic epidermolysis bullosa, early Alzheimer’s disease, neuroinflammation, inflammatory disease and oncology.
INmune Bio has announced significant results from its Phase 1 study for XPro™, a selective DN-TNF inhibitor aimed at treating Alzheimer's disease (AD). The treatment resulted in a 46% decrease in CSF pT217, a promising biomarker for AD, and improved MRI metrics indicate remyelination. This data demonstrates reductions in biomarkers associated with neuroinflammation and neurodegeneration. A Phase 2 trial is set to begin by the end of 2021, enrolling 200 patients. Preliminary findings will be discussed in a webinar on September 7, 2021.
INmune Bio, Inc. (NASDAQ: INMB) announced positive results from the first patient receiving INKmune™ for high-risk myelodysplastic syndrome (MDS). The therapy successfully activated natural killer (NK) cells, generating memory-like NK (mlNK) cells as predicted by in vitro studies. The patient showed no adverse symptoms of Cytokine Release Syndrome (CRS) and had a doubling of NK cell numbers by day 8. The results indicate INKmune™ can effectively convert resting NK cells into more potent cancer-fighting cells, with further trials planned for additional patients.
INmune Bio, Inc. (NASDAQ: INMB) announced that President and CEO Raymond J. Tesi will present at the Canaccord Genuity 41st Annual Growth Conference from August 10 to 12, 2021. Tesi's presentation is scheduled for August 11, 2021, at 9:00 AM ET. The conference will also allow for virtual one-on-one meetings with INmune Bio representatives. The company focuses on developing treatments to enhance the innate immune system to combat diseases, with key product platforms aimed at various conditions including COVID-19, cancer, and Alzheimer's.
INmune Bio, Inc. (NASDAQ: INMB) announced that its President and CEO, Raymond J. Tesi, MD, will present at the BTIG Virtual Biotechnology Conference on August 9, 2021, at 1:00 PM Eastern Time. The conference will be held virtually on August 9-10, and attendees can schedule one-on-one meetings with INmune Bio through their BTIG representatives.
INmune Bio focuses on developing treatments that leverage the innate immune system to combat diseases, with ongoing clinical trials for various innovative therapies.
INmune Bio, Inc. (NASDAQ: INMB) reported its Q2 2021 financial results and provided a business update on August 4, 2021. The company is progressing towards a Phase 2 clinical trial of XPRO™ in mild Alzheimer’s patients, aiming to start by year-end. Recent financial highlights include a net loss of $6.7 million and increased R&D expenses of $4.5 million. The company raised $51.9 million in July 2021, securing funding for its upcoming trials. Notably, the first patient has been treated in the Phase 1 trial of INKmune for high-risk myelodysplastic syndrome.
INmune Bio, Inc. (NASDAQ: INMB) will host a conference call on August 4, 2021, at 4:30 PM ET to discuss its second-quarter results for the period ending June 30, 2021. The call will provide a corporate update, and participants can join by dialing in 5-10 minutes early. A transcript and replay will be available shortly after the call. The company focuses on developing treatments utilizing the innate immune system, with platforms targeting conditions like COVID-19, cancer, Alzheimer’s, and chronic inflammation.
INmune Bio announced the design of a Phase 2 clinical trial of XProTM for mild Alzheimer’s disease (AD), involving 168 patients over six months. The trial aims to assess the impact of reducing neuroinflammation on cognition. Preliminary data from a Phase 1b study indicated improvements in white matter metrics and biomarkers of neuroinflammation with a 1.0 mg/kg dose. A recent $40 million financing will support this Phase 2 trial, which is set to start in Q4 2023, with data expected in 2H2023.
INmune Bio (NASDAQ: INMB) has acquired LUMICKS' z-Movi® Cell Avidity Analyzer to enhance its Natural Killer (NK) Cell Priming Platform, INKmune®. This cutting-edge technology allows INmune to measure the efficacy of NK cells against tumors by analyzing the avidity of cell interactions. Preliminary data suggests that improved NK cell avidity may enhance tumor cell killing. This acquisition aims to streamline potency screening and establish biomarkers, accelerating drug development for cancer therapies.
INmune Bio, Inc. (NASDAQ: INMB) announced plans to commence a Phase 2 study of XPro1595 for Alzheimer’s disease by the end of 2021, following promising Phase 1b results. The upcoming study aims to further evaluate the drug's efficacy in reducing neuroinflammation, which has shown potential in improving biomarkers related to neurodegeneration. The company will present findings at the Alzheimer’s Association International Congress 2021, detailing the positive outcomes from its earlier study.
INmune Bio, Inc. (NASDAQ: INMB) announced a registered direct offering of 1,818,182 shares at $22.00 per share, raising approximately $40 million. The offering, set to close on July 16, 2021, is facilitated by A.G.P./Alliance Global Partners. Proceeds will support working capital, corporate purposes, and advancement of product candidates, particularly the Phase 2 trial of XPro1595 for Alzheimer’s disease, expected to start by year-end 2021. This funding aims to fully support the Alzheimer’s Phase II program.