Welcome to our dedicated page for Inmune Bio news (Ticker: INMB), a resource for investors and traders seeking the latest updates and insights on Inmune Bio stock.
INmune Bio Inc. develops clinical-stage immunology and biotechnology treatments designed to target the innate immune system in disease. Company news commonly centers on three platforms: CORDStrom, a pooled allogeneic human umbilical cord-derived mesenchymal stromal/stem cell platform; XPro, a dominant-negative TNF platform intended to selectively neutralize soluble TNF; and INKmune, a cell-based medicine designed to prime natural killer cells against residual cancer.
Recurring updates include clinical and preclinical data, regulatory pathway discussions, manufacturing and collaboration agreements, conference presentations, shareholder communications, and quarterly or annual financial results. Coverage also reflects program areas such as recessive dystrophic epidermolysis bullosa, early Alzheimer’s disease, neuroinflammation, inflammatory disease and oncology.
INmune Bio (NASDAQ: INMB) submitted a pre-submission package for CORDStrom to the UK MHRA on February 10, 2026, seeking early scientific and regulatory feedback to streamline a full MAA.
The company reported MissionEB trial improvements in itch, pain, skin integrity and QoL, three commercial pilot manufacturing runs meeting release criteria in Stevenage, and plans to file an MAA mid-summer 2026 with EU and U.S. submissions targeted for Q4 2026. CORDStrom holds U.S. Orphan Drug and Rare Pediatric Disease designations; recent legislation reauthorizes the FDA Rare Pediatric Disease PRV program through 9/30/2029.
INmune Bio (NASDAQ: INMB) CEO David Moss reviewed 2025 progress and outlined 2026 priorities, highlighting clinical and regulatory milestones for two lead programs: CORDStrom for recessive dystrophic epidermolysis bullosa (RDEB) and XPro (XPro1595) for Alzheimer’s disease. Key 2025 items include three commercial pilot-scale manufacturing runs for CORDStrom, a planned MAA submission in mid‑summer 2026 to the UK MHRA and a targeted BLA submission late 2026 to FDA (timelines subject to regulatory feedback). XPro’s Phase 2 MINDFuL showed biomarker‑defined signals (EMACC effect size 0.27) guiding a precision‑medicine registrational path. Cash and equivalents were approximately $27.7M as of Sept 30, 2025, with financing and rebates expected to fund operations through year‑end 2026.
INmune Bio (NASDAQ: INMB) announced a peer-reviewed overview on mesenchymal stromal cell (MSC) therapies published in Cytotherapy, titled “Fate and Function of Exogenously Administered MSCs: Current Insights and Future Directions.”
Lead scientist on INmune’s CORDStrom™ R&D, Dr Nikita M. Patel, was one of the senior authors on an invitation-only working party that reviewed current knowledge and gaps for MSC development. Topics included systemic delivery, local/depot delivery (the CORDStrom™ approach), and in vivo persistence. The company said it is initially developing CORDStrom™ for RDEB and expects to file a BLA and MAA in 2026.
INmune Bio (NASDAQ: INMB) reported new Phase 2 neuroimaging analyses from the MINDFuL trial of XPro1595 in early Alzheimer’s disease patients with elevated neuroinflammation (ADi). Presented at CTAD Dec 1-4, 2025, the PerpPD+ grey-matter MRI analysis showed a trend toward slowed progression of cortical disarray in XPro1595-treated, dose-compliant ADi participants at 24 weeks.
The company says these imaging signals align with directional improvements in biological, cognitive, and neuropsychiatric endpoints and that additional MRI analyses are expected in 2026.
INmune Bio (NASDAQ: INMB) will present two scientific posters at the 18th Clinical Trials on Alzheimer’s Disease (CTAD) in San Diego on Dec 1–4, 2025. The company will present Phase 2 MINDFuL results for XPro1595 (a selective soluble TNF neutralizer) during a session running from 3:30 PM Dec 1 to 5:30 PM Dec 2 PT at location P057 with presenting author Kim A. Staats, PhD. A second presentation, led by Sarah Barnum, PhD of Cognition Metrics, will report validation work on the Early Mild Alzheimer’s Cognitive Composite (EMACC) and its associations with blood biomarkers on Dec 4, 2025 at location P316.
INmune Bio (NASDAQ: INMB) reported Q3 2025 results and operational milestones on October 30, 2025. The company posted a net loss of $6.5M vs $12.1M in Q3 2024 and held $27.7M cash as of September 30, 2025, with ~26.6M shares outstanding as of October 30, 2025.
Clinical progress: completed two pilot-scale CORDStrom manufacturing runs with an MAA planned mid-2026 and anticipated subsequent BLA; XPro1595 (DN-TNF) Phase 2 MINDFuL data show clinical benefits in an amyloid-positive, high-inflammation subgroup and an excellent safety profile; INKmune CARE-PC met its primary endpoint and two secondary endpoints with final data pending.
INmune Bio (NASDAQ: INMB) will report third-quarter 2025 financial results and provide a corporate update on Thursday, October 30, 2025. Management will host a conference call and live audio webcast at 4:30 PM Eastern Time to discuss results for the quarter ended September 30, 2025.
Dial-in details: domestic 1-800-225-9448, international 1-203-518-9708, Conference ID: INMUNE. The live webcast is available at the company webcast link. A transcript will be posted ~24 hours after the call. A replay is available through November 13, 2025 by dialing 1-844-512-2921 or 1-412-317-6671 (international) and entering PIN 11159914.
INmune Bio (NASDAQ: INMB) announced that CEO David Moss will participate in a Dermatologic Rare Disease Panel at the Maxim Growth Summit on October 22, 2025 in New York City.
The panel is moderated by Jason McCarthy, Ph.D. and Mr. Moss will discuss INmune Bio’s CORDStrom™ advanced cell platform for treating Recessive Dystrophic Epidermolysis Bullosa (RDEB). Mr. Moss will be available for one-on-one meetings during the conference. Event dates: Oct 22–23, 2025; panel time: Oct 22, 8:30am ET. Registration information is provided on the event page.
INmune Bio (NASDAQ: INMB) has submitted results from its Phase 2 MINDFuL trial of XPro™ in Alzheimer's disease to npj Dementia journal. While the trial did not meet its primary endpoint in the overall population, it showed promising results in a specific subgroup of patients with both amyloid pathology and high inflammatory burden (ADi population).
Key findings in the ADi population demonstrated positive trends across cognitive, neuropsychiatric, and biological endpoints. Notably, XPro™ showed a complete absence of amyloid-related imaging abnormalities (ARIA), a common side effect in other Alzheimer's treatments, even in high-risk patients including APOE4 carriers. The company expects FDA regulatory feedback in Q1 2026.
INmune Bio (NASDAQ: INMB) has successfully completed its first commercial pilot-scale manufacturing run of CORDStrom™, a cell therapy treatment for Recessive Dystrophic Epidermolysis Bullosa (RDEB), at the Cell and Gene Therapy Catapult facility in the UK.
The milestone keeps the company on track for filing a Marketing Authorization Application (MAA) in the UK during H1 2026, followed by a Biologics License Application (BLA) in the US. CORDStrom™, which showed promising results in Phase 2 trials, is an off-the-shelf, allogeneic therapy derived from umbilical cord tissue mesenchymal stromal cells.
The successful manufacturing run demonstrates the scalability and consistency of CORDStrom™ production using a proprietary GMP-compliant process, marking a crucial step toward commercialization for treating RDEB patients.