Korro Reports First Quarter 2026 Financial Results and Provides Corporate Update
Rhea-AI Summary
Korro (Nasdaq: KRRO) reported Q1 2026 results and a corporate update on May 7, 2026. Cash and marketable securities totaled $157.1M as of March 31, 2026, after an oversubscribed $85M private placement. Lead program KRRO-121 targets hyperammonemia with a regulatory filing expected in H2 2026. A GalNAc AATD program achieved >90% in vivo RNA editing; a development candidate is expected in Q2 2026. Company expects cash runway into H2 2028 and will present multiple data sets at ASGCT 2026.
Positive
- Cash position of $157.1M as of March 31, 2026
- Completed $85M oversubscribed private placement
- KRRO-121 regulatory filing planned in H2 2026
- GalNAc AATD program achieved >90% in vivo RNA editing
Negative
- No collaboration revenue in Q1 2026 versus $2.6M prior year
- Net loss of $19.6M for Q1 2026
News Market Reaction – KRRO
In the May 7 session, KRRO declined 3.37%, reflecting a moderate negative market reaction. Argus tracked a trough of -4.9% from its starting point during tracking. Our momentum scanner triggered 6 alerts that day, indicating moderate trading interest and price volatility.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Previous Earnings Reports
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Mar 12 | Earnings and update | Positive | +11.3% | KRRO-121 nomination, GalNAc AATD progress, and oversubscribed $85M financing. |
| Nov 12 | Quarterly results | Negative | -79.3% | KRRO-110 fell short of target levels, workforce cuts, restructuring charges disclosed. |
| Aug 12 | Quarterly results | Positive | +6.3% | Progress in Phase 1/2a REWRITE trial and solid cash position into 2027. |
| May 07 | Quarterly results | Positive | +10.6% | Q1 2025 results with runway extension and KRRO-110 readout timeline reiterated. |
| Mar 18 | Annual results | Neutral | -3.5% | Full-year 2024 results with higher R&D and G&A and extended cash runway. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Earnings and financial updates have historically produced large, sometimes extreme moves, including one major drawdown tied to KRRO-110 data and restructuring.
Over the past year, earnings events for Korro have combined pipeline updates with shifting capital and cost structures. Earlier results on Mar 12, 2026 paired KRRO-121 nomination and an $85M private placement, while the Nov 12, 2025 update highlighted underwhelming KRRO-110 data, workforce cuts, and runway changes. Prior quarters emphasized REWRITE trial progress and growing cash balances. Today’s Q1 2026 report continues this theme with strengthened cash of $157.1M, reduced R&D and G&A, and reiterated timelines for KRRO-121 and the GalNAc AATD program.
Key Terms
hyperammonemia medical
urea cycle disorders medical
hepatic encephalopathy medical
galnac-conjugated medical
oligonucleotide medical
rna editing medical
pre-funded warrants financial
private placement financial
AI-generated analysis. How Rhea-AI works. Not financial advice.
- Hosted virtual Analyst Day showcasing lead program KRRO-121’s potential to be a first-in-class transformational treatment for hyperammonemia in patients with urea cycle disorders (UCDs) and hepatic encephalopathy (HE); regulatory filing for KRRO-121 expected in the second half of 2026
- Advanced early-stage research and development programs highlighted by a GalNac-conjugated oligonucleotide for alpha-1 antitrypsin deficiency (AATD); on track to announce development candidate in second quarter of 2026
- Executed oversubscribed
$85 million private placement to support the achievement of value inflection points for multiple RNA editing clinical programs and extend cash runway into the second half of 2028
CAMBRIDGE, Mass., May 07, 2026 (GLOBE NEWSWIRE) -- Korro Bio, Inc. (Korro) (Nasdaq: KRRO), a biopharmaceutical company leveraging a novel oligonucleotide promoted editing of RNA (OPERA®) platform to develop a new class of genetic medicines for rare and highly prevalent diseases, today reported results for the first quarter ended March 31, 2026, and provided a corporate update.
“The first quarter marked significant scientific progress for Korro as we continued to advance our OPERA platform and build a pipeline of differentiated RNA editing medicines,” commented Ram Aiyar, Ph.D., Chief Executive Officer and President of Korro Bio. “Our lead program, KRRO-121, remains on track for its regulatory filing in the second half of 2026, bringing us closer to delivering a potential first-in-class treatment for patients suffering from hyperammonemia in urea cycle disorders and hepatic encephalopathy. At the same time, our GalNAc-conjugated program for alpha-1 antitrypsin deficiency achieved greater than
First Quarter 2026 Highlights and Recent Developments
- Hosted Analyst Day showcasing KRRO-121’s potential to treat hyperammonemia in patients with UCDs and HE
- Forum featured Bruce Scharschmidt, MD, hepatologist and former Chief Medical Officer of Hyperion Therapeutics, and Michelle Dinon, parent of a child impacted by a UCD and UCD patient advocate.
- Focused on profiling the unmet need in serving both patient populations afflicted with hyperammonemia, and KRRO-121’s potential to become a first-in-class transformational treatment.
- Advanced a GalNac-conjugated oligonucleotide for AATD
- Achieved >
90% in vivo RNA editing, demonstrating the high therapeutic potential of RNA editing oligonucleotides and highlighting the possibility of repeat dose therapy to achieve the functional equivalent of a DNA modification without altering the genome. Preliminary preclinical data from Korro’s AATD GalNac program to be presented at the American Society of Gene and Cell Therapy 29th Annual Meeting (ASGCT) taking place on May 11-15, 2026.
- Achieved >
- Executed oversubscribed
$85 million private placement led by Venrock Healthcare Capital Partners with strong participation from new and existing investors- Expected to extend cash runway into the second half of 2028 and provide sufficient capital to report clinical data for KRRO-121 and AATD programs.
- Continued to refine the potency of Korro’s RNA editors by making improvements to its oligonucleotide chemistry that boost the efficiency of its proprietary OPERA platform. Data to be presented at ASGCT 2026.
- Advanced pre-clinical R&D for AMPKγ1 as “longevity” medicine to circumvent age-related metabolic diseases and TDP-43 for amyotrophic lateral sclerosis (ALS).
- Participated in leading healthcare dedicated investor conferences and scientific forums
- 44th Annual JP Morgan Healthcare Conference, TD Cowen 46th Annual Healthcare Conference.
- 3rd International Conference on Ureagenesis Defects and Allied Conditions.
Upcoming Milestones
- Announce development candidate for GalNAc AATD Program in the second quarter of 2026
- Regulatory filing for KRRO-121 in the second half of 2026
- Nominate development candidate for a third GalNAc-conjugated program in the second half of 2026
Upcoming Scientific and Investor Conferences
- American Society of Gene and Cell Therapy 29th Annual Meeting (ASGCT), May 11th– 15th
- Tides USA 2026: Oligonucleotide and Peptide Therapeutic Conference, May 11th-14th
- EASL Congress 2026, May 27th-30th
- HCW 4th Annual BioConnect Nasdaq Investor Conference, May 19th
- 2026 RBC Capital Markets Global Healthcare Conference, May 20th
First Quarter 2026 Financial Results
Cash Position: Cash, cash equivalents and marketable securities were
Collaboration Revenue: There was no collaboration revenue for the three months ended March 31, 2026, as compared to
Research and Development (R&D) Expenses: R&D expenses were
General and Administration (G&A) Expenses: G&A expenses were
Net Loss: Korro’s net loss was
About Korro
Korro is a biopharmaceutical company leveraging a novel oligonucleotide promoted editing of RNA (OPERA®) platform to develop a new class of genetic medicines for rare and highly prevalent diseases. OPERA provides precise, tissue-directed delivery of oligonucleotides that modify the targeted native mRNA transcript to repair or form a de-novo protein with enhanced functionality. The platform combines a suite of capabilities consisting of sophisticated knowledge of transcription biology through ADAR proteins (Adenosine Deaminases Acting on RNA), machine learning optimization of oligonucleotides, linker chemistry expertise, along with use of a highly targeted tissue-specific delivery methodology. As such, the OPERA platform has enabled Korro to generate and advance a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process, providing precise yet transient single base edits to produce therapeutic proteins with augmented activity versus its endogenous counterpart. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary OPERA platform with precedented delivery modalities, including N-acetylgalactosamine (GalNAc) conjugated for delivery for subcutaneous administration, manufacturing know-how, and established regulatory pathways of approved oligonucleotide medicines. Korro is based in Cambridge, Massachusetts. For more information, visit korrobio.com.
Korro intends to use its Investor Relations website, LinkedIn, and X (Twitter) as means of disclosing material nonpublic information and for complying with its disclosure obligations under Regulation FD. Accordingly, investors should monitor Korro’s Investor Relations website and follow @KorroBio on LinkedIn, and X (Twitter), in addition to following Korro’s press releases, SEC filings, public conference calls, presentations, and webcasts.
About Hyperammonemia
Hyperammonemia, the dangerous accumulation of ammonia in the blood, manifests across multiple indications, including urea cycle disorders (UCDs) and hepatic encephalopathy (HE). UCDs are rare inborn errors of metabolism involving deficiencies of enzymes required for ureagenesis, the process of converting ammonia to urea for excretion. The absence or deficiency of any of the urea cycle enzymes can result in hyperammonemia and an increased risk of hyperammonemic crises (HACs), which can result in severe and permanent neurological symptoms, coma, and death. HE is a neuropsychiatric complication of liver disease characterized by cognitive dysfunction and altered consciousness. HE is primarily caused by the liver’s inability to adequately detoxify ammonia, typically occurring in patients with liver cirrhosis. This leads to ammonia accumulating in the bloodstream and crossing the blood-brain barrier, causing brain dysfunction that ranges from subtle cognitive impairment to severe confusion and coma.
About KRRO-121
KRRO-121 is a GalNAc-conjugated RNA editing oligonucleotide for the potential treatment of hyperammonemia in patients with UCDs of any mutational background as well as patients with HE. Utilizing Korro’s proprietary OPERA® platform, KRRO-121 is designed to generate a stabilized, de novo glutamine synthetase (GS) protein, a critical enzyme involved in ammonia clearance. This synthetic rescue approach is designed to augment ammonia clearance in hyperammonemia-driven diseases such as UCDs and HE. Korro’s preclinical data support the potential for KRRO-121 to be a pan-UCD treatment that may control ammonia levels, along with the potential to enable diet liberalization, reduce dependence on nitrogen scavengers, and lower the risk of HACs. KRRO-121 also has the potential to enhance ammonia control in HE patients, which may reduce the risk of recurrent HE episodes. KRRO-121 may offer infrequent subcutaneous dosing, which, if confirmed in clinical studies, could offer significant improvement over current treatments that require multiple daily doses. KRRO-121 has the potential to be a differentiated, first-in-class, disease-modifying therapy for both UCD and HE.
Forward-Looking Statements
Certain statements in this press release may constitute “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements include, but are not limited to, express or implied statements regarding expectations, hopes, beliefs, intentions or strategies of Korro regarding the future including, without limitation, express or implied statements regarding: the timing of the regulatory filing for KRRO-121; the first-in-class potential of, and market opportunity for, KRRO-121 as a treatment for hyperammonemia for patients with UCDs and HE; timing of announcing a development candidate for Korro’s GalNAc-conjugated program for AATD and third GalNAc-conjugated program; Korro’s cash runway and financial resources; the therapeutic potential of the OPERA platform; reaching clinical milestones across multiple programs; and the possibility of achieving functional equivalent of DNA modification; among others. In addition, any statements that refer to projections, forecasts, or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “possible,” “potential,” “predict,” “project,” “should,” “strive,” “would,” “aim,” “target,” “commit,” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that statement is not forward looking. Forward-looking statements are based on current expectations and assumptions that, while considered reasonable are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to, various factors beyond management’s control including risks associated with pre-clinical studies and conducting clinical trials; risks associated with validating in clinical trials observations from pre-clinical studies; risks associated with collaborating with third parties; other risks associated with protecting intellectual property; as well as risks associated with general economic conditions; and other risks and uncertainties indicated from time to time in Korro’s filings with the Securities and Exchange Commission (SEC), including Part II Item 1A. “Risk Factors” in Korro’s Quarterly Report on Form 10-Q filed with the SEC on the date hereof, as such may be amended or supplemented by its other filings with the SEC. Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place undue reliance on forward-looking statements in this press release, which speak only as of the date they are made and are qualified in their entirety by reference to the cautionary statements herein. Except as required by law, Korro does not undertake or accept any duty to release publicly any updates or revisions to any forward-looking statements to reflect any change in its expectations or in the events, conditions or circumstances on which any such statement is based. This press release does not purport to summarize all of the conditions, risks and other attributes of an investment in Korro.
Korro Bio Contact Information
Investor & Media Contact
Malini Chatterjee, Ph.D
Blueprint Life Science Group
mchatterjee@bplifescience.com or ir@korrobio.com
917.330.4269
| Korro Bio, Inc. Condensed Consolidated Statements of Operations and Comprehensive Loss (in thousands, except share and per share amounts) (unaudited) | ||||||||
| Three Months Ended March 31, | ||||||||
| 2026 | 2025 | |||||||
| Revenue: | ||||||||
| Collaboration revenue | $ | — | $ | 2,550 | ||||
| Operating expenses: | ||||||||
| Research and development | 12,951 | 19,739 | ||||||
| General and administrative | 7,485 | 7,831 | ||||||
| Total operating expenses | 20,436 | 27,570 | ||||||
| Loss from operations | (20,436 | ) | (25,020 | ) | ||||
| Other income: | ||||||||
| Other income, net | 906 | 1,633 | ||||||
| Total other income, net | 906 | 1,633 | ||||||
| Loss before provision for income taxes | (19,530 | ) | (23,387 | ) | ||||
| Provision for income taxes | (95 | ) | — | |||||
| Net loss | $ | (19,625 | ) | $ | (23,387 | ) | ||
| Other comprehensive income: | ||||||||
| Unrealized loss on available-for-sale marketable securities | $ | (224 | ) | $ | (3 | ) | ||
| Foreign currency translation adjustments, net | $ | 17 | $ | (1 | ) | |||
| Comprehensive loss | $ | (19,832 | ) | $ | (23,391 | ) | ||
| Net loss per share, basic and diluted | $ | (1.69 | ) | $ | (2.49 | ) | ||
| Weighted-average shares used in computing net loss per share, basic and diluted | 11,598,717 | 9,384,266 | ||||||
| Korro Bio, Inc. Selected Condensed Consolidated Balance Sheet Data (in thousands) (unaudited) | ||||||||
| March 31, 2026 | December 31, 2025 | |||||||
| Cash, cash equivalents and marketable securities | $ | 157,053 | $ | 85,187 | ||||
| Working capital(1) | 105,376 | 70,435 | ||||||
| Total assets | 183,622 | 113,506 | ||||||
| Total liabilities | 63,989 | 62,067 | ||||||
| Total stockholders' equity | 119,633 | 51,439 | ||||||
| (1) Working capital is defined as current assets less current liabilities. | ||||||||
