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Lyell Immunopharma, Inc. - LYEL STOCK NEWS

Welcome to our dedicated page for Lyell Immunopharma news (Ticker: LYEL), a resource for investors and traders seeking the latest updates and insights on Lyell Immunopharma stock.

Lyell Immunopharma, Inc. (Nasdaq: LYEL) is a clinical-stage company pioneering T-cell reprogramming to create cell therapies for patients with solid tumors. By employing advanced genetic and epigenetic technologies, Lyell aims to overcome major challenges in current cell-based immunotherapies, including T-cell exhaustion and lack of durable stemness. Their innovative approach has led to a robust pipeline featuring product candidates like LYL797, LYL119, and LYL845.

Lyell's product portfolio is designed to address the unmet needs in cancer treatment. LYL797 targets ROR1-positive cancers such as triple-negative breast cancer and non-small cell lung cancer, incorporating genetic reprogramming to overexpress c-Jun and epigenetic reprogramming for enhanced durability. LYL119 is another ROR1-targeted CAR T-cell therapy that uses four reprogramming technologies for sustained function and cytotoxicity. LYL845, a tumor-infiltrating lymphocyte (TIL) product, is enhanced with Lyell's proprietary Epi-R™ protocol to improve potency and durability.

Recent achievements include the FDA granting Orphan Drug Designation for LYL845 in advanced melanoma. The company's innovative Epi-R P2 manufacturing process has shown potential to reduce TIL culture time significantly. Lyell is also advancing collaborations, such as with Outpace Bio, to develop localized IL-12 activity in tumors, enhancing the efficacy of T-cell therapies.

Lyell's business strategy has been bolstered by a strong financial position, with cash reserves extending operational capabilities into 2027. Despite macroeconomic challenges, Lyell continues to focus on generating clinical data and advancing its clinical programs, aiming to deliver transformative treatments for cancer patients.

For the latest updates on Lyell Immunopharma, including their financial performance and ongoing clinical trials, visit their official website.

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Lyell Immunopharma, Inc. (Nasdaq: LYEL) reported financial results for Q4 and full year 2022, highlighting a net loss of $8.4 million for Q4 and $183.1 million for the year, but significantly increased revenue of $48.4 million for Q4 and $84.7 million for the year, up from $2.8 million and $10.7 million in 2021. The company's cash position stands at $710.3 million as of December 31, 2022, supporting ongoing clinical trials and a robust pipeline. Lyell initiated Phase 1 trials for two product candidates targeting solid tumors and presented promising nonclinical data at several conferences. The company expects initial clinical data from LYL797 and LYL845 in 2024.

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Lyell Immunopharma will present at the 41st Annual J.P. Morgan Healthcare Conference on January 10 at 4:30 pm PT. The presentation will showcase Lyell's pipeline, including CAR T cell product candidates LYL797 and LYL845, both in Phase 1 trials, and the innovative LYL119 targeting ROR1. Key technologies will be highlighted, such as NR4A3 gene knockout and Stim-RTM for enhanced CAR T cell activity. A live webcast will be available on the company’s website with a 30-day replay.

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Lyell Immunopharma (Nasdaq: LYEL) has appointed Lynn Seely, MD, as president & CEO, succeeding Liz Homans, who transitions to a consulting role until June 2024. Dr. Seely brings extensive biopharmaceutical leadership experience, having previously served as CEO of Myovant Sciences, where she successfully launched therapies for cancer and women's health. Under her leadership, Lyell aims to advance its clinical-stage programs and enhance its T-cell reprogramming technologies to improve treatment outcomes for solid tumors.

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Lyell Immunopharma (Nasdaq: LYEL) is set to participate in the BofA Securities 2022 Biotech SMID Cap Conference on December 8, 2022, at 1:40 pm ET. The event will feature members of its senior management team, and a live webcast will be available on the company's website. This opportunity highlights Lyell's commitment to developing curative cell therapies for solid tumors, leveraging proprietary technologies to overcome key barriers in adoptive T-cell therapy. A replay of the webcast will be accessible for 90 days post-event.

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Lyell Immunopharma, Inc. (Nasdaq: LYEL), a clinical-stage T-cell reprogramming company, announced participation in the Barclays Virtual Fireside Chat Series on November 17 at 11 a.m. ET. The event will feature senior management discussing advancements in curative cell therapies for solid tumors. A webcast of the presentation can be accessed on the company's investor relations website, with a replay available for 90 days afterwards. Lyell focuses on overcoming challenges in adoptive T-cell therapy through innovative genetic and epigenetic reprogramming technologies.

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FAQ

What is the current stock price of Lyell Immunopharma (LYEL)?

The current stock price of Lyell Immunopharma (LYEL) is $0.9603 as of October 31, 2024.

What is the market cap of Lyell Immunopharma (LYEL)?

The market cap of Lyell Immunopharma (LYEL) is approximately 231.0M.

What does Lyell Immunopharma do?

Lyell Immunopharma is a clinical-stage company focusing on T-cell reprogramming to develop cell therapies for patients with solid tumors.

What are Lyell's main product candidates?

Lyell's main product candidates include LYL797, a ROR1-targeted CAR T-cell therapy; LYL119, another ROR1-targeted CAR T-cell product; and LYL845, an enhanced TIL therapy.

What recent achievements has Lyell reported?

Lyell recently received FDA Orphan Drug Designation for LYL845 in advanced melanoma and has advanced collaborations to enhance T-cell therapies.

What technologies does Lyell use in their therapies?

Lyell employs ex vivo genetic and epigenetic reprogramming technologies to tackle barriers like T-cell exhaustion and lack of durable stemness.

What is the financial outlook for Lyell?

As of March 31, 2024, Lyell reported cash reserves sufficient to fund operations into 2027, keeping them focused on advancing their clinical programs.

Where is Lyell Immunopharma located?

Lyell Immunopharma is based in South San Francisco, California, with additional facilities in Seattle and Bothell, Washington.

What is Epi-R™ manufacturing protocol?

Epi-R™ is Lyell's proprietary epigenetic reprogramming protocol designed to enhance the potency and durability of TIL products.

What type of cancers are Lyell's therapies targeting?

Lyell's therapies target a variety of solid tumors, including triple-negative breast cancer, non-small cell lung cancer, and advanced melanoma.

How can I get updates on Lyell Immunopharma's developments?

You can visit their official website at www.lyell.com for the latest updates and detailed information on their projects and clinical trials.

What is Lyell's approach to addressing T-cell exhaustion?

Lyell's approach includes using genetic and epigenetic reprogramming technologies to create T cells with improved durability and ability to resist exhaustion.

Lyell Immunopharma, Inc.

Nasdaq:LYEL

LYEL Rankings

LYEL Stock Data

230.99M
256.00M
15.34%
67.09%
4.2%
Biotechnology
Pharmaceutical Preparations
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United States of America
SOUTH SAN FRANCISCO