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MannKind Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Business Update

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MannKind (Nasdaq: MNKD) reported Q4 2025 revenue of $112M, up 46% year-over-year, and full year 2025 revenue of $349M, up 22% vs. 2024. Furoscix and Afrezza each generated about $23M in Q4 2025.

The company completed the scPharma acquisition, holds $176M in cash and investments, and flagged two FDA PDUFA dates: Afrezza pediatric on May 29, 2026 and Furoscix ReadyFlow on July 26, 2026. Nintedanib DPI Phase 1b topline data expected in 2H 2026.

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Positive

  • Total revenue +46% in Q4 2025
  • Full-year revenue +22% in 2025
  • Furoscix net sales $23M following acquisition
  • Afrezza Q4 sales $23M, +25% YoY
  • Completed acquisition of scPharma on Oct 7, 2025

Negative

  • Cost of goods sold commercial +190% in Q4 2025
  • R&D expenses +148% in Q4 2025
  • SG&A expenses +144% in Q4 2025

Key Figures

Q4 2025 revenues: $111.955M FY 2025 revenues: $348.966M Q4 2025 Afrezza net sales: $22.878M +5 more
8 metrics
Q4 2025 revenues $111.955M Quarter ended Dec 31, 2025; +46% vs Q4 2024
FY 2025 revenues $348.966M Year ended Dec 31, 2025; +22% vs 2024
Q4 2025 Afrezza net sales $22.878M Up 25% vs Q4 2024
Q4 2025 Furoscix revenue $23.178M Contribution beginning Oct 7, 2025 acquisition date
Q4 2025 royalties $33.564M Up 24% vs Q4 2024, driven by Tyvaso DPI
Cash & investments $176M As of Dec 31, 2025
FY 2025 R&D expenses $66.3M Up 45% vs 2024, driven by MNKD-101 and MNKD-201
FY 2025 SG&A expenses $144.1M Up 53% vs 2024, including Furoscix-related costs

Market Reality Check

Price: $3.50 Vol: Volume 36430742 vs 20-day...
high vol
$3.50 Last Close
Volume Volume 36430742 vs 20-day average 4642520 (relative volume 7.85) indicates heavy trading interest. high
Technical Shares at $3.5, trading below 200-day MA of $4.93 and 46.24% below the $6.51 52-week high, near the $3.29 52-week low.

Peers on Argus

MNKD fell 36.82% while momentum peers were mixed: AUPH up 4.64%, SRPT down 4.01%...
1 Up 2 Down

MNKD fell 36.82% while momentum peers were mixed: AUPH up 4.64%, SRPT down 4.01%, VRDN down 4.98%. This points to a stock-specific reaction rather than a broad biotech move.

Common Catalyst Several biotech peers, including VCEL and AUPH, also reported earnings, suggesting an earnings-heavy news day across the group.

Previous Earnings Reports

5 past events · Latest: Nov 05 (Positive)
Same Type Pattern 5 events
Date Event Sentiment Move Catalyst
Nov 05 Q3 2025 earnings Positive +10.6% Reported Q3 2025 revenue of <b>$82.1M</b> and detailed scPharma acquisition.
Aug 06 Q2 2025 earnings Positive -13.2% Strong Q2 2025 revenues of <b>$76.5M</b> and return to net income.
May 08 Q1 2025 earnings Positive -4.5% Q1 2025 revenues of <b>$78.4M</b> with higher net and non-GAAP income.
Feb 26 FY 2024 results Positive -4.4% Reported <b>$286M</b> 2024 revenue and <b>$28M</b> net income with strong growth.
Nov 07 Q3 2024 earnings Positive -0.6% Q3 2024 revenue of <b>$70M</b> and YTD revenue of <b>$209M</b> driven by Tyvaso DPI.
Pattern Detected

Earnings releases have generally reported growth but often saw flat-to-negative next-day moves, with more divergences than alignments.

Recent Company History

Over the past five earnings cycles, MannKind has consistently highlighted revenue growth, with quarterly totals such as $70M in Q3 2024 and $82.1M in Q3 2025, alongside expanding Tyvaso DPI royalties and Afrezza sales. The company also completed the scPharmaceuticals acquisition and advanced multiple clinical programs. Despite these positive updates, four of the last five earnings events were followed by negative price reactions, framing today’s large decline against a history of market skepticism around results.

Historical Comparison

-2.4% avg move · Past earnings headlines for MNKD averaged a -2.42% next-day move, usually modestly negative. Today’s...
earnings
-2.4%
Average Historical Move earnings

Past earnings headlines for MNKD averaged a -2.42% next-day move, usually modestly negative. Today’s -36.82% reaction to Q4/FY 2025 results is a major downside outlier versus prior earnings behavior.

Earnings releases have shown a revenue progression from $70M in Q3 2024 to $82.1M in Q3 2025, alongside growing Tyvaso DPI royalties and Afrezza sales, now culminating in Q4 2025 revenues of $111.955M and full-year $348.966M including Furoscix.

Market Pulse Summary

This announcement details strong top-line growth, with Q4 2025 revenues of $111.955M and full-year $...
Analysis

This announcement details strong top-line growth, with Q4 2025 revenues of $111.955M and full-year $348.966M, supported by Afrezza and Furoscix contributions and higher Tyvaso DPI royalties. It also highlights upcoming regulatory catalysts with PDUFA dates in 2026 and advancing programs like Nintedanib DPI. At the same time, R&D and SG&A expenses increased meaningfully, reflecting pipeline investment and acquisition-related costs, which investors may monitor in future quarters.

Key Terms

pdufa, snda, biologics license application, new drug application, +1 more
5 terms
pdufa regulatory
"Afrezzaa0pediatric indication PDUFA date May 29, 2026"
PDUFA, short for the Prescription Drug User Fee Act, is a law that allows drug companies to pay fees to the government to speed up the review process for new medicines. This helps bring important drugs to market more quickly, which can impact their availability and pricing. For investors, PDUFA timelines can influence the timing of a drug’s approval and potential market success.
snda regulatory
"supplemental New Drug Application (sNDA) for Furoscixa0ReadyFlowa0Autoinjector"
A SNDA (Subordination, Non‑Disturbance and Attornment Agreement) is a legal pact among a property owner’s lender, the owner’s tenants, and sometimes the landlord that sets who keeps lease rights if the property is sold or a mortgage is enforced. Think of it as a rulebook that decides whether a tenant can stay and keep paying rent or must answer to a new owner after a foreclosure. For investors, an SNDA matters because it protects predictable rental income, clarifies who has priority on claims against a property, and therefore affects a property’s value and the security of related loans.
biologics license application regulatory
"supplemental Biologics License Applicationa0(sBLA)a0fora0Afrezza in pediatrics"
A biologics license application is a formal request submitted to regulatory authorities seeking approval to market a new biological medicine, such as vaccines or treatments made from living organisms. It is a comprehensive review process that evaluates the safety, effectiveness, and manufacturing quality of the product. For investors, receiving approval signals that a biological therapy can be sold to the public, potentially leading to revenue growth and market success.
new drug application regulatory
"supplemental New Drug Application (sNDA) for Furoscixa0ReadyFlowa0Autoinjector"
A new drug application is a formal request submitted to government regulators seeking approval to market a new medicine. It is like a detailed proposal that shows the drug has been tested for safety and effectiveness. For investors, receiving approval signals that the drug may soon become available for sale, potentially leading to revenue growth and impacting the company's value.
technosphere technical
"using MannKinda0a0proprietary Technosphereae platform"
The technosphere is the global layer of human-made technology, devices, networks and infrastructure—everything from factories and data centers to sensors and software—that companies use to make, move and sell goods and services. For investors it matters because changes, breakdowns or upgrades in that layer (like a new platform, supply-chain automation, or cybersecurity failures) can quickly alter costs, competitive advantage and future profits, much like a city’s roads and utilities determine how well businesses run.

AI-generated analysis. Not financial advice.

Conference call today at 9:00 am ET

  • Q4 2025 revenues of $112M, +46% vs. Q4 2024
    • Furoscix® Q4 2025 net sales of $23M, +91% vs. Q4 2024
    • Afrezza® Q4 2025 net sales of $23M, +25% vs. Q4 2024
  • 2025 full year revenues of $349M, +22% vs. 2024
  • Successfully completed the acquisition of scPharmaceuticals Inc. (scPharma)
  • Program updates:
    • Afrezza pediatric indication PDUFA date May 29, 2026
    • Furoscix ReadyFlow Autoinjector PDUFA date July 26, 2026 

DANBURY, Conn. and WESTLAKE VILLAGE, Calif., Feb. 26, 2026 (GLOBE NEWSWIRE) -- MannKind Corporation (Nasdaq: MNKD) a biopharmaceutical company dedicated to transforming chronic disease care through innovative, patient-centric solutions for cardiometabolic and orphan lung diseases, today reported financial results for the fourth quarter and year ended December 31, 2025, and provided a business update.

“MannKind closed 2025 with strong momentum across our commercial portfolio and meaningful progress in our pipeline. The addition of Furoscix strengthens our cardiometabolic franchise, while Afrezza and UT-related revenues continue to deliver sustained growth,” said Michael Castagna, PharmD, Chief Executive Officer of MannKind Corporation. “As we enter a catalyst‑rich 2026, with two upcoming FDA decisions, and Nintedanib DPI INFLO-1 Phase 1b topline data, we believe we are well‑positioned to drive long‑term value for patients, providers and shareholders. Our team’s hard work over the last several years is culminating in significant milestones with the potential to drive near-term growth.”

Business Update and Upcoming Milestones 
Commercial Products  
Furoscix

  • Furoscix (furosemide injection) generated $23 million in net sales following the October 7, 2025, acquisition, compared to $12 million in Q4 2024 as reported by scPharma, a 91% increase
  • FDA accepted for review a supplemental New Drug Application (sNDA) for Furoscix ReadyFlow Autoinjector; with a PDUFA target action date of July 26, 2026; if approved, it would deliver an IV-equivalent diuretic dose (subcutaneous furosemide injection 80 mg/ml) in under 10 seconds

Afrezza 

  • Afrezza (insulin human) Inhalation Powder Q4 2025 net sales were $23 million, compared to $18 million in Q4 2024, a 25% increase
  • FDA accepted for review the supplemental Biologics License Application (sBLA) for Afrezza in pediatrics, with a PDUFA target action date of May 29, 2026; if approved, it would be the first needle-free insulin option for pediatric patients
  • In Q1 2026, the FDA approved updated Afrezza label providing starting dose guidance when switching from multiple daily injections (MDI) or insulin pump mealtime therapy  
  • ADA Standards of Care in Diabetes – 2026 now recommends clinicians evaluate inhaled insulin as a prandial option at every patient visit, moving it into routine care conversations and creating a catalyst for broader adoption  
  • Afrezza launched in India by Cipla

Development
Nintedanib DPI (MNKD-201) 

  • Enrollment underway in Phase 1b (INFLO-1) study, top line data expected in 2H 2026 
  • Initiated Phase 2 clinical trial (INFLO-2) in idiopathic pulmonary fibrosis (IPF) and plan to enroll first patient in Q2 2026

Other Programs

  • Formulating investigational molecule (MNKD-1501) under the expanded collaboration with United Therapeutics (UT) using MannKind’s proprietary Technosphere® platform
  • Initiated pre-clinical development of Bumetanide DPI (MNKD-701)  

Corporate Update

  • Completed acquisition of scPharma on October 7, 2025
  • Cash, cash equivalents and investments as of December 31, 2025, totaled $176 million
Fourth Quarter and Full Year 2025 Financial Results
 
RevenuesThree Months
Ended December 31,
 
 2025  2024  $ Change  % Change 
Revenues(Dollars in thousands) 
Royalties$33,564  $27,009  $6,555   24%
Collaborations and services 27,986   26,710   1,276   5%
Afrezza 22,878   18,279   4,599   25%
Furoscix(1) 23,178      23,178  N/A 
V-Go 4,349   4,778   (429)  (9%)
Total revenues$111,955  $76,776  $35,179   46%


(1) Amount represents revenue earned beginning on the scPharma acquisition date of October 7, 2025.

 Year
Ended December 31,
 
 2025  2024  $ Change  % Change 
Revenues(Dollars in thousands) 
Royalties$128,116  $102,335  $25,781   25%
Collaborations and services 106,713   100,840   5,873   6%
Afrezza 74,587   64,041   10,546   16%
Furoscix(1) 23,178      23,178  N/A 
V-Go 16,372   18,288   (1,916)  (10%)
Total revenues$348,966  $285,504  $63,462   22%


(1) Amount represents revenue earned beginning on the scPharma acquisition date of October 7, 2025.

Total revenues for the fourth quarter and full year 2025 rose due to increases in revenue from royalties, collaborations and services, and commercial product sales. The increase in royalties was due to UT’s increase in net revenue from sales of Tyvaso DPI®. Collaborations and services revenue grew due to increased units sold to UT. Revenue from commercial sales increased primarily due to net sales from Furoscix beginning on the scPharma acquisition date of October 7, 2025 as well as an increase in net sales of Afrezza over the prior periods.

Operating Expenses and Other Financial Highlights

  • Cost of goods sold – commercial, excluding amortization of acquired intangible assets, was $13.9 million for the fourth quarter of 2025, compared to $4.8 million for the same period in 2024, an increase of 190%. For the full year 2025, Cost of goods sold – commercial, excluding amortization of acquired intangible assets, was $26.8 million, compared to $17.4 million for the same period in 2024, an increase of 54%. These increases are primarily attributable to the inclusion of Furoscix following the acquisition on October 7, 2025, as well as increased sales of Afrezza.

  • Cost of revenue – collaborations and services was $15.7 million for the fourth quarter of 2025, compared to $14.8 million for the same period in 2024, an increase of 6%. For the full year 2025, cost of revenue – collaborations and services was $61.2 million, compared to $59.2 million for the same period in 2024, an increase of 3%. These increases are primarily the result of a higher number of units of Tyvaso DPI sold through to UT compared to the prior periods.

  • Research and development ("R&D") expenses were $27.6 million for the fourth quarter of 2025 compared to $11.1 million for the same period in 2024, an increase of 148%. For the full year 2025, R&D expenses were $66.3 million compared to $45.9 million in the same period in 2024, an increase of 45%. These increases were primarily attributable to the ICoN-1 clinical study for MNKD-101, which was discontinued in the fourth quarter of 2025, clinical production scale-up for MNKD-201, personnel costs primarily due to a full-year of costs associated with the third quarter of 2024 Pulmatrix transaction, which bolstered our research capabilities and capacity, and ReadyFlow Autoinjector-related expenses. These increases were partially offset by the completion of INHALE-3, the Phase 1 clinical study for MNKD-201, and toxicology studies in 2024, as well as lower costs for INHALE-1 as the study was closed out in the second quarter of 2025.

  • Selling, general and administrative ("SG&A") expenses were $58.4 million for the fourth quarter of 2025 compared to $24.0 million for the same period in 2024, an increase of 144%. For the full year 2025, SG&A expenses were $144.1 million compared to $94.3 million in the same period in 2024, an increase of 53%. These increases primarily reflect the inclusion of SG&A costs associated with the promotion and support of Furoscix as well as transaction-related costs incurred as part of the acquisition of scPharma. The remainder of the increase was largely attributable to higher headcount and personnel-related expenses in our commercial group as well as increased promotional costs in preparation to support the potential pediatric launch of Afrezza in 2026.

Conference Call
MannKind will host a conference call and presentation webcast to discuss these results today at 9:00 a.m. Eastern Time. The webcast will be accessible via a link on MannKind’s website. A replay will also be available in the same location within 24 hours after the call and accessible for approximately 90 days.

About MannKind
MannKind Corporation (Nasdaq: MNKD) is a biopharmaceutical company dedicated to transforming chronic disease care through innovative, patient-centric solutions. Focused on cardiometabolic and orphan lung diseases, we develop and commercialize treatments that address serious unmet medical needs, including diabetes, pulmonary hypertension, and fluid overload in heart failure and chronic kidney disease.

With deep expertise in drug-device combinations, MannKind aims to deliver therapies designed to fit seamlessly into daily life.

Learn more at mannkindcorp.com.

Forward-Looking Statements
Statements in this press release that are not statements of historical fact are forward-looking statements that involve risks and uncertainties. These statements include, without limitation, statements regarding MannKind's expectations about 2026 being a catalyst-rich year; the FDA’s potential approval of the sBLA for Afrezza for the pediatric population and of the sNDA for Furoscix ReadyFlow Autoinjector, and the expected timing thereof; expectations regarding MannKind’s ongoing and planned clinical trials and nonclinical studies, including the timing for enrollment for the Phase 2 clinical trial of MNKD-201 in IPF and the expected timing for data readouts from the Phase 1b clinical trial of MNKD-201, and preclinical development of MNKD-701; the potential benefits of Furoscix ReadyFlow Autoinjector and Afrezza Inhalation Powder in pediatrics, if approved; the ADA’s Standards of Care in Diabetes 2026 recommendations for inhaled insulin creating a catalyst for broader adoption; and MannKind being positioned to drive long-term value. Words such as “believes,” “anticipates,” “plans,” “expects,” “intend,” “will,” “goal,” “potential” and similar expressions are intended to identify forward-looking statements. These forward-looking statements are based upon MannKind’s current expectations. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks associated with developing product candidates; risks and uncertainties related to unforeseen delays that may impact the timing of clinical trials and reporting data; risks associated with safety and other complications of our products and product candidates; risks associated with the regulatory review process; risks associated with competition; manufacturing risks; market adoption risks; and other risks detailed in MannKind’s filings with the Securities and Exchange Commission (“SEC”), including under the “Risk Factors” heading of its Annual Report on Form 10-K for the year ended December 31, 2025, being filed with the SEC later today. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. All forward-looking statements are qualified in their entirety by this cautionary statement, and MannKind undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date of this press release.

Tyvaso DPI is a trademark of United Therapeutics Corporation.

Furoscix is a registered trademark and Furoscix ReadyFlow is a trademark of scPharmaceuticals Inc., a subsidiary of MannKind Corporation.

AFREZZA, MANNKIND, TECHNOSPHERE and V-GO are registered trademarks of MannKind Corporation.

MannKind Contacts:
Investor Relations
Kate Miranda
(617) 921-5461
Email: ir@mnkd.com

Media Relations
Christie Iacangelo
(818) 292-3500
Email: media@mnkd.com

MANNKIND CORPORATION AND SUBSIDIARIES CONSOLIDATED STATEMENTS OF OPERATIONS
 Three Months
Ended December 31,
  Year
Ended December 31,
 
 2025  2024  2025  2024 
 (In thousands except per share data) 
Revenues:           
Commercial product sales$50,405  $23,057  $114,137  $82,329 
Collaborations and services 27,986   26,710   106,713   100,840 
Royalties 33,564   27,009   128,116   102,335 
Total revenues 111,955   76,776   348,966   285,504 
Expenses:           
Cost of goods sold – commercial, excluding amortization of acquired intangible assets 13,927   4,808   26,800   17,429 
Cost of revenue – collaborations and services 15,746   14,796   61,160   59,173 
Research and development 27,588   11,138   66,348   45,893 
Selling, general and administrative 58,411   23,972   144,135   94,329 
Amortization of acquired intangible assets 3,973      3,973    
(Gain) loss on foreign currency transaction (3)  (4,433)  7,749   (3,907)
Total expenses 119,642   50,281   310,165   212,917 
(Loss) income from operations (7,687)  26,495   38,801   72,587 
Other income (expense):           
Interest income, net 1,637   2,825   8,053   12,615 
Interest expense on liability for sale of future royalties (3,885)  (3,452)  (14,449)  (16,172)
Interest expense on financing liability (2,451)  (2,467)  (9,750)  (9,828)
Impairment of available-for-sale investment       (6,409)  (1,550)
Interest expense (7,536)  (1,562)  (13,830)  (11,981)
Other (expense) income (1,009)     (1,009)  32 
Gain on bargain purchase          5,259 
Loss on settlement of debt    (13,394)     (20,444)
Total other expense (13,244)  (18,050)  (37,394)  (42,069)
Income before income tax (benefit) expense (20,931)  8,445   1,407   30,518 
Income tax (benefit) expense (4,983)  1,023   (4,456)  2,930 
Net (loss) income$(15,948) $7,422  $5,863  $27,588 
Net (loss) income per share – basic$(0.05) $0.03  $0.02  $0.10 
Weighted average shares used to compute net (loss) income
per share – basic
 307,260   279,191   305,639   274,415 
Net (loss) income per share – diluted$(0.05) $0.03  $0.02  $0.10 
Weighted average shares used to compute net (loss) income
per share – diluted(1)
 307,260   290,631   314,112   283,844 


(1) Diluted weighted average shares ("DWAS") differs from basic weighted average shares due to the weighted average number of shares that would be outstanding upon exercise or vesting of outstanding share-based payments to employees and conversion of convertible notes. For the year ended December 31, 2025, DWAS included 8.5 million shares issuable upon exercise or vesting of outstanding share-based payments. 

MANNKIND CORPORATION AND SUBSIDIARIES CONSOLIDATED BALANCE SHEETS
        
 December 31, 2025  December 31, 2024 
 (In thousands except share 
and per share data)
ASSETS     
Current assets:     
Cash and cash equivalents$74,882  $46,339 
Short-term investments 96,464   150,917 
Accounts receivable, net 38,367   11,804 
Inventory 35,313   27,886 
Prepaid expenses and other current assets 46,553   31,360 
Total current assets 291,579   268,306 
Restricted cash 745   737 
Long-term investments 5,012   5,482 
Property and equipment, net 82,423   85,365 
Goodwill 67,595   1,931 
Developed technology - on-body infusor 190,027    
IPR&D - ReadyFlow Formulation 129,600    
Other intangible assets 5,072   5,265 
Other assets 20,129   26,757 
Total assets$792,182  $393,843 
      
LIABILITIES AND STOCKHOLDERS' DEFICIT     
Current liabilities:     
Accounts payable$9,034  $6,792 
Accrued expenses and other current liabilities 64,628   40,293 
Senior convertible notes – current 36,280    
Liability for sale of future royalties – current 14,298   12,283 
Contingent consideration - current 21,132    
Financing liability – current 10,328   10,062 
Deferred revenue – current 15,331   12,407 
Total current liabilities 171,031   81,837 
Liability for sale of future royalties – long term 136,985   137,362 
Financing liability – long term 93,092   93,877 
Deferred revenue – long term 39,977   51,160 
Recognized loss on purchase commitments – long term 65,952   58,204 
Operating lease liability 10,689   11,645 
Contingent consideration -long term 5,114    
Milestone liabilities 2,003   2,523 
Term loan 318,361    
Senior convertible notes    36,051 
Total liabilities 843,204   472,659 
Commitments and contingencies     
Stockholders' deficit:     
Undesignated preferred stock, $0.01 par value – 10,000,000 shares authorized;     
   no shares issued or outstanding as of December 31, 2025 or December 31, 2024
Common stock, $0.01 par value – 800,000,000 shares authorized; 3,078   3,029 
   307,832,587 and 302,959,782 shares issued and outstanding as of
  December 31, 2025 and December 31, 2024, respectively
Additional paid-in capital 3,141,741   3,118,865 
Accumulated other comprehensive income 115   1,109 
Accumulated deficit (3,195,956)  (3,201,819)
Total stockholders' deficit (51,022)  (78,816)
Total liabilities and stockholders' deficit$792,182  $393,843 


Non-GAAP Measures

To supplement our consolidated financial statements presented under GAAP, we are presenting non-GAAP net income (loss) and non- GAAP net income (loss) per share - basic, which are non-GAAP financial measures. We are providing these non-GAAP financial measures to disclose additional information to facilitate the comparison of past and present operations, and they are among the indicators management uses as a basis for evaluating our financial performance. We believe that these non-GAAP financial measures, when considered together with our GAAP financial results, provide management and investors with an additional understanding of our business operating results, including underlying trends.

These non-GAAP financial measures are not meant to be considered in isolation or as a substitute for comparable GAAP measures; should be read in conjunction with our consolidated financial statements prepared in accordance with GAAP; have no standardized meaning prescribed by GAAP; and are not prepared under any comprehensive set of accounting rules or principles. In addition, from time to time in the future there may be other items that we may exclude for purposes of our non-GAAP financial measures; and we may in the future
cease to exclude items that we have historically excluded for purposes of our non-GAAP financial measures. Likewise, we may determine to modify the nature of its adjustments to arrive at our non-GAAP financial measures. Because of the non-standardized definitions of non- GAAP financial measures, the non-GAAP financial measures as used by us in this report have limits in their usefulness to investors and may be calculated differently from, and therefore may not be directly comparable to, similarly titled measures used by other companies.

The following table reconciles our financial measures for net income (loss) and net income (loss) per share ("EPS") for basic weighted average shares as reported in our consolidated statement of operations to a non-GAAP presentation:

 Three Months
Ended December 31,
  Year
Ended December 31,
 2025  2024  2025  2024 
 Net Income  Basic EPS  Net Income  Basic EPS  Net Income  Basic EPS  Net Income
(Loss)
  Basic EPS 
 (In thousands except per share data)
GAAP reported net (loss) income$(15,948) $(0.05) $7,422  $0.03  $5,863  $0.02  $27,588  $0.10 
Non-GAAP adjustments:                       
Stock compensation 6,972   0.02   5,818   0.02   24,195   0.08   21,358   0.08 
Interest expense on liability for sale of future royalties 3,885   0.01   3,452   0.01   14,449   0.05   16,172   0.06 
Sold portion of royalty revenue(1) (3,357)  (0.01)  (2,701)  (0.01)  (12,812)  (0.04)  (10,234)  (0.04)
Acquisition-related expenses(2) 6,017   0.03         9,690   0.03      
Amortization of intangible assets acquired 3,973   0.01         3,973   0.01       
(Gain) loss on foreign currency transaction (3)     (4,433)  (0.02)  7,749   0.03   (3,907)  (0.01)
Impairment loss on available-for-sale investment             6,409   0.01   1,550   0.01 
Gain on bargain purchase                  (5,259)  (0.02)
Loss on settlement of debt       13,394   0.05        20,444   0.07 
Non-GAAP adjusted net income (loss)$1,539  $0.01  $22,952  $0.08  $59,516  $0.19  $67,712  $0.25 
Weighted average shares used to compute net income (loss)
per share – basic
 307,260      279,191      305,639      274,415    


(1) Represents the non-cash portion of the 1% royalty on net sales of Tyvaso DPI earned during the years ended December 31, 2025 and 2024 which is remitted to the royalty purchaser and recognized as royalties from collaborations in our consolidated statements of operations. Our revenues from royalties from collaborations during the year ended December 31, 2025 and 2024 totaled $128.1 million and $102.3 million, respectively, of which $12.8 million and $10.2 million, respectively, is remitted to the royalty purchaser.
(2) Represents transaction fees incurred during the year ended December 31, 2025 associated with the acquisition of scPharma.


FAQ

What were MannKind (MNKD) Q4 2025 revenues and growth rates?

MNKD reported Q4 2025 revenue of $112 million, a 46% increase year-over-year. According to the company, increases were driven by royalties, collaborations and commercial product sales including Afrezza and Furoscix following the scPharma acquisition.

How did Furoscix contribute to MannKind (MNKD) results in Q4 2025?

Furoscix generated $23 million in Q4 2025 net sales after acquisition in October. According to the company, Furoscix sales plus integration of scPharma materially increased commercial revenue and related cost of goods sold.

When are the FDA PDUFA dates for Afrezza and Furoscix for MNKD?

Afrezza pediatric sBLA has a PDUFA date of May 29, 2026, and Furoscix ReadyFlow sNDA is July 26, 2026. According to the company, these are target action dates for potential regulatory decisions.

What did MannKind report about cash and the scPharma acquisition for MNKD?

MNKD reported $176 million in cash, cash equivalents and investments as of December 31, 2025. According to the company, it completed the acquisition of scPharma on October 7, 2025, which added Furoscix sales.

How did expenses change at MannKind in Q4 2025 and why?

R&D rose 148% and SG&A rose 144% in Q4 2025 versus prior year. According to the company, increases reflect clinical programs, ReadyFlow costs, Furoscix-related promotion and acquisition transaction expenses.

When should investors expect Nintedanib DPI (MNKD-201) data for MannKind (MNKD)?

Topline Phase 1b (INFLO-1) data for MNKD-201 are expected in the second half of 2026. According to the company, INFLO-1 enrollment is underway and INFLO-2 Phase 2 initiation is planned in 2026.
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1.70B
297.35M
Biotechnology
Pharmaceutical Preparations
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United States
DANBURY