Welcome to our dedicated page for MediciNova news (Ticker: MNOV), a resource for investors and traders seeking the latest updates and insights on MediciNova stock.
Medicinova, Inc. (NASDAQ: MNOV), headquartered in La Jolla, California, is a clinical-stage biopharmaceutical company focused on acquiring and developing promising small-molecule therapeutics to treat diseases with unmet medical needs. Specializing in therapies for neurological disorders and fibrotic diseases, Medicinova has a strategic emphasis on the U.S. market.
Medicinova’s robust product portfolio includes several innovative drugs in late-stage clinical development. These include MN-001 (tipelukast) and MN-166 (ibudilast), both of which boast multiple mechanisms of action and strong safety profiles. MN-166 (ibudilast) is in Phase 3 clinical trials for amyotrophic lateral sclerosis (ALS) and degenerative cervical myelopathy (DCM), and is Phase 3-ready for progressive multiple sclerosis (MS). It is also being evaluated in Phase 2 trials for Long COVID, substance dependence, and other neurodegenerative diseases.
The company recently received a series of new patents, significantly extending its intellectual property protection. One such patent covers the use of MN-166 for treating macular injury and decreasing macular volume loss associated with progressive multiple sclerosis. Another patent covers the formulation of MN-166 in extended-release oral forms, which is expected to improve patient compliance and reduce side effects.
Medicinova has demonstrated the potential of MN-166 in ophthalmic neurodegenerative diseases, supported by positive data from various animal model studies and the SPRINT-MS Phase 2b trial. Additionally, MN-166 is under investigation for its efficacy in treating glioblastoma, Long COVID, chemotherapy-induced peripheral neuropathy (CIPN), and substance use disorder.
Alongside its development efforts, Medicinova has a strong track record of securing investigator-sponsored clinical trials funded through government grants. This financial support underscores the promise and potential of its therapies to address critical medical needs.
For more information or investor inquiries, please contact Geoff O'Brien, Vice President at info@medicinova.com.
MediciNova, a biopharmaceutical company listed on NASDAQ (MNOV) and Tokyo Stock Exchange, announces that David H. Crean, Ph.D., its Chief Business Officer, will now oversee investor engagement and public relations. Dr. Crean aims to enhance communication channels, providing stakeholders with clearer insights into the company’s vision and strategy. MediciNova plans to increase transparency through regular updates on milestones and achievements, hoping to attract new investors. CEO Yuichi Iwaki highlighted the company's active programs in neurodegeneration and other independently run projects that are expected to generate additional cash flow upon regulatory approvals. The company acknowledges a previous disconnect in market communication and is committed to improving clarity under Dr. Crean's leadership.
MediciNova has received a Notice of Allowance from the U.S. Patent and Trademark Office for a patent application covering MN-166 (ibudilast) for preventing metastasis in cancers like pancreatic, lung, breast, colorectal, melanoma, and ovarian cancers.
The patent, expected to expire by July 2042, includes claims for using MN-166 in combination with therapies such as chemotherapy and immunotherapy.
It covers various administration methods, doses, and treatment durations, enhancing the intellectual property and value of MN-166.
Dr. Kazuko Matsuda, Chief Medical Officer, emphasized the significance of this patent in addressing metastasis, a major cause of cancer-related deaths.
MediciNova announced data from their Phase 1b/2a clinical trial of MN-166 (ibudilast) combined with Temozolomide (TMZ) in glioblastoma patients at the ASCO Annual Meeting 2024. The study included 62 patients, split between newly diagnosed (36) and recurrent (26) GBM cases. Primary endpoints were safety, tolerability, and efficacy. The combination treatment was safe and well-tolerated, with no unexpected adverse effects. Progression-Free Survival at 6 months (PFS6) was 44% for new and 31% for recurrent GBM, higher than historical controls in recurrent cases. Median PFS was 8.7 months for new and 2.4 months for recurrent GBM. Median Overall Survival was 21 months for new and 8.6 months for recurrent GBM. Preclinical data suggests improved survival with MN-166 and PD-1/PD-L1 antibody therapy combination. Future trials will evaluate this combination further.
MediciNova announced two poster presentations at the 92nd European Atherosclerosis Society (EAS) 2024 Congress. The presentations highlighted the efficacy, safety, and tolerability of MN-001 (Tipelukast) for non-alcoholic fatty liver disease (NAFLD) and its metabolite MN-002's effects on cholesterol efflux. The Phase 2 clinical trial for MN-001 has enrolled 33 patients, with 14 completing the study. Three serious adverse events were reported but deemed unrelated to the drug. MN-002 was shown to significantly enhance cholesterol efflux and protein expression in a dose-dependent manner, with notable increases in ABCA1 and ABCG1 mRNA levels.
MediciNova, a biopharmaceutical company listed on NASDAQ and Tokyo Stock Exchange, announced it has received a Notice of Allowance from the U.S. Patent and Trademark Office for a patent covering MN-166 (ibudilast) for preventing metastasis in eye cancer. The patent, expected to expire by July 2042, covers the use of MN-166 for uveal melanoma, detailing various doses, frequencies, and treatment periods. MN-166 impedes uveal melanoma migration by inhibiting the macrophage migration inhibitory factor and reducing immune suppressive cells, enhancing CD8 T cell activity. The company views this patent as enhancing the potential value of MN-166 in oncology.
MediciNova announced that it has received a Notice of Allowance from the U.S. Patent and Trademark Office for a patent application covering MN-166 (ibudilast) for treating chlorine-induced acute respiratory distress syndrome (ARDS). This patent, expected to expire no earlier than January 2042, includes claims for MN-166 as a monotherapy or in combination with other drugs, and covers various administration methods and dosing frequencies. The announcement follows a promising nonclinical model study showing significant improvements in pulmonary function and survival rates with MN-166. Chief Medical Officer Kazuko Matsuda expressed optimism about the potential value this patent adds to MN-166.
MediciNova, Inc. has received a new patent from the U.S. Patent and Trademark Office covering extended-release formulations of MN-166 (ibudilast), set to expire after September 2040. The patent includes claims for tablet or capsule formulations at various doses. Chief Medical Officer, Kazuko Matsuda, sees this patent as enhancing the value of MN-166 by offering patient convenience and potentially reducing side effects.
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