MaxCyte launches CHANGE-seq-BE™ and ONE-seq-BE™ to strengthen off-target assessment for genome editing therapies
Rhea-AI Summary
MaxCyte (NASDAQ: MXCT) announced the launch of CHANGE-seq-BE™ and ONE-seq-BE™, new off-target nomination assays for adenine and cytosine base editors, offered through its SeQure™ gene editing risk assessment service.
CHANGE-seq-BE is described as a sensitive, unbiased biochemical method to nominate off-target sites for base editors, while ONE-seq-BE is presented as the only base-editor nomination assay that provides full visibility into population-specific genetic variants that may influence off-target activity. SeQure integrates outputs from these orthogonal assays and existing confirmation assays for quantitative off-target editing and structural variation detection, helping therapeutic developers assess off-target risks in relevant cell and tissue contexts and align with evolving regulatory expectations, including recent FDA guidance on off-target editing and genome safety.
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Key Figures
Historical Context
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Aug 12 | Q2 earnings report | Positive | +9.4% | Loss narrowed, guidance was reiterated, and the Genentech partnership was highlighted. |
| Jul 21 | Genentech partnership | Positive | +5.1% | Multi-platform license partnership expanded access to MaxCyte technology. |
| Jul 15 | Q2 earnings date | Neutral | -4.9% | The company scheduled its Q2 financial results and conference call. |
| May 12 | Q1 earnings report | Positive | +24.1% | Guidance was reiterated, losses narrowed, and a share repurchase was authorized. |
| Apr 29 | Q1 earnings date | Neutral | +7.6% | The company scheduled its Q1 financial results and conference call. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Recent reactions were positive after both earnings reports and the Genentech partnership, but mixed after earnings-date notices.
Key Terms
off-target nomination assays technical
adenine base editors technical
cytosine base editors technical
orthogonal assays technical
AI-generated analysis. How Rhea-AI works. Not financial advice.
ROCKVILLE, Md., Aug. 19, 2026 (GLOBE NEWSWIRE) -- MaxCyte, Inc. (NASDAQ: MXCT), a leading, cell-engineering focused company providing enabling platform technologies to advance the discovery, development and commercialization of next-generation cell therapeutics, today announced the launch of the CHANGE-seq-BE™ and ONE-seq-BE™ off-target nomination assays. Available through MaxCyte’s SeQure™ service, these assays address a key gap in genome editing characterization by offering sensitive nomination of off-target sites for adenine and cytosine base editors (ABEs and CBEs).
SeQure provides integrated reporting across orthogonal nomination assays, enabling therapeutic developers to identify overlapping and distinct nominated sites and to prioritize regions for confirmation assays. CHANGE-seq-BE is a sensitive, unbiased biochemical off-target nomination method for base editors, and ONE-seq-BE is the only nomination assay for base editors that provides full visibility of population-specific genetic variants that may impact off-target activity. By combining these two assays, MaxCyte is uniquely positioned as a single-source provider of orthogonal nomination assays for base editors. Together with SeQure’s existing confirmation assays for quantitative off-target editing measurement and structural variation detection, therapeutic developers can confidently assess off-target risks in the relevant cell and tissue context. This is especially important as developers work to align with evolving regulatory expectations – including recent FDA guidance on off-target editing and genome safety – with a growing emphasis on orthogonal assays, assay sensitivity, and modality-appropriate methods.
Maher Masoud, President and CEO at MaxCyte, commented: “Base editors are creating new opportunities for therapeutic development, while also requiring safety assessment strategies that reflect their mechanisms of action. The addition of CHANGE-seq-BE and ONE-seq-BE to our SeQure services gives developers access to sensitive, orthogonal off-target assessment capabilities that can help them to better understand and mitigate off-target risk, building stronger data packages for clinical development.”
For more information about MaxCyte’s SeQure services, please visit maxcyte.com/sequre.
About MaxCyte
At MaxCyte®, we are committed to building better cells together. As a leading cell-engineering company, we are driving the discovery, development and commercialization of next-generation cell therapies. Our best-in-class Flow Electroporation® technology and SeQure™ gene editing risk assessment services enable high-performance cell engineering and rigorous evaluation of editing outcomes, supporting confidence in therapeutic development. Supported by expert scientific, technical and regulatory guidance, our platform empowers researchers to engineer diverse cell types and payloads, accelerating the development of safe and effective treatments for human health. For more than 25 years, we've been advancing cell engineering, shaping the future of medicine.
Learn more at maxcyte.com and follow us on LinkedIn and Bluesky.
MaxCyte Contacts:
Investor Relations
Gilmartin Group
Erik Abdow
ir@maxcyte.com
Media Contact
Oak Street Communications
Kristen White
kristen@oakstreetcommunications.com
415.608.6060
Editorial contact for further information or follow-up:
Sarah Ballard at kdm communications limited, St Neots, UK
Tel. +44 (0)1480 405333 Fax: +44 (0)1480 477833
email ideas@kdm-communications.com
