Nurix Therapeutics Announces Presentations at the 67th American Society of Hematology (ASH) Annual Meeting

Rhea-AI Summary

Nurix Therapeutics (Nasdaq: NRIX) announced that updated clinical data from the NX-5948-301 Phase 1a/1b trial will be presented at the 67th ASH Annual Meeting, December 6–9, 2025 in Orlando.

Two company clinical presentations will feature: an oral presentation reporting new results in relapsed/refractory chronic lymphocytic leukemia (CLL) on Dec 6, 2025 at 9:45 a.m. ET, and a poster with updated Waldenström macroglobulinemia results on Dec 8, 2025 at 6:00 p.m. ET. In addition, a separate poster will present new mechanistic insights on BTK resistance (BTK A428D mutation) on Dec 6, 2025 at 5:30 p.m. ET.

The presenters named include Zulfa Omer, M.D. (CLL oral), Scott Huntington, M.D., MPH (Waldenström poster), and Quinlan Sievers, M.D., Ph.D. (BTK resistance poster).

SAN FRANCISCO, Nov. 03, 2025 (GLOBE NEWSWIRE) -- Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of targeted protein degradation medicines in oncology and autoimmune disease, today announced that updated clinical data from the NX-5948-301 Phase 1a/1b clinical trial have been selected for presentation at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition, taking place December 6 – 9, 2025, in Orlando, Florida. The data will be featured in two presentations: an oral presentation with new results in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) and a poster presentation with updated results in patients with Waldenström macroglobulinemia.

In addition to these clinical presentations, Nurix and its collaborators will also present new mechanistic insights into resistance to Bruton’s tyrosine kinase (BTK) targeted therapies at a separate ASH poster session, highlighting discoveries that expand the understanding of BTK biology.

Oral Presentation Details:

Title: Bexobrutideg (NX-5948), a Novel Bruton’s Tyrosine Kinase (BTK) Degrader, Demonstrates Rapid and Durable Clinical Responses in Relapsed / Refractory Chronic Lymphocytic Leukemia (CLL): New and Updated Findings from an Ongoing Phase 1a/b Trial
Presenter: Zulfa Omer, M.D., Assistant Professor Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA
Session Name: 642. Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Treatment of CLL in Relapse and in Richter Transformation
Abstract #: 86
Session Date and Time: Saturday, December 6, 2025, 9:30 a.m. – 11:00 a.m. ET
Presentation Time: 9:45 a.m. – 10:00 a.m. ET
Room: Orange County Convention Center - W224ABEF

Poster Presentation Details

Title: Bexobrutideg (NX-5948), a Novel Bruton’s Tyrosine Kinase (BTK) Degrader, Shows High Clinical Activity and Tolerable Safety in Patients with Waldenström Macroglobulinemia: Updated Results from an Ongoing Phase 1a/b Study
Presenter: Scott Huntington M.D., MPH, Associate Professor of Internal Medicine (Hematology), Yale School of Medicine
Session Name: 623: Mantle Cell, Follicular, Waldenstrom’s, and Other Indolent B Cell Lymphomas: Clinical and Epidemiological: Poster III
Abstract # 5359
Session Date and Time: Monday, December 8, 2025, 6:00 p.m. – 8:00 p.m. ET
Location: Orange County Convention Center - West Halls BЗ – B4

Title: Molecular and Structural Basis of Pan-Resistance to BTK Targeting Therapies via BTK A428D Mutation
Presenter: Quinlan Sievers, M.D., Ph.D. Memorial Sloan Kettering Cancer Center, New York, NY
Session Name: 641:Chronic Lymphocytic Leukemia: Basic and Translational Poster I
Abstract # 2102
Session Date and Time: Saturday, December 6, 2025, 5:30 p.m. – 7:30 p.m. ET
Location: Orange County Convention Center - West Halls BЗ – B4

About Bexobrutideg (NX-5948)
Bexobrutideg is an investigational, orally bioavailable, brain penetrant, small molecule degrader of BTK currently being evaluated in the DAYBreak CLL-201 clinical trial (NCT07221500), a pivotal single-arm Phase 2 study of bexobrutideg in patients with relapsed or refractory chronic lymphocytic leukemia. Nurix also continues enrollment in the NX-5948-301 Phase 1a/1b clinical trial (NCT05131022) of bexobrutideg in patients with relapsed or refractory B cell malignancies. Additional information on the ongoing clinical trials can be accessed at clinicaltrials.gov.

About Nurix Therapeutics, Inc.
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and autoimmune diseases. Nurix’s wholly owned, clinical stage pipeline includes degraders of Bruton’s tyrosine kinase (BTK), a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene B (CBL-B), an E3 ligase that regulates activation of multiple immune cell types including T cells and NK cells. Nurix also is advancing multiple potentially first-in-class or best-in-class degraders and degrader antibody conjugates (DACs) in its preclinical pipeline. Nurix’s partnered drug discovery pipeline consists of a preclinical stage degrader of STAT6, a clinical stage degrader of IRAK4, and multiple additional programs under collaboration agreements with Gilead Sciences, Inc., Sanofi S.A. and Pfizer Inc., within which Nurix retains certain options for co-development, co-commercialization and profit sharing in the United States for multiple drug candidates. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease. Nurix is headquartered in San Francisco, California. For additional information visit http://www.nurixtx.com.

Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 and other federal securities laws. Any statements contained herein that do not describe historical facts, including, but not limited to, statements regarding the Nurix’s intention to present updated data from the clinical trials of bexobrutideg at the 67th American Society of Hematology Annual Meeting, are forward-looking statements that involve risks and uncertainties that could cause actual results to differ materially from those discussed in such forward-looking statements. Such risks and uncertainties include, among others, the risks described under the heading “Risk Factors” in Nurix’s Quarterly Report on Form 10-Q for the period ended August 31, 2025, and subsequent filings with the SEC. Any of these risks and uncertainties could materially and adversely affect Nurix’s business and results of operations, which could, in turn, have a significant and adverse impact on Nurix’s stock price. Nurix cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. Nurix undertakes no obligation to update publicly any forward-looking statements to reflect new information, events or circumstances after the date they were made or to reflect the occurrence of unanticipated events.

Contacts:

Investors
Kris Fortner
Nurix Therapeutics, Inc.
ir@nurixtx.com

Elizabeth Wolffe, Ph.D.
Wheelhouse Life Science Advisors
lwolffe@wheelhouselsa.com

Media
Aljanae Reynolds
Wheelhouse Life Science Advisors
areynolds@wheelhouselsa.com 

FAQ

What will Nurix Therapeutics (NRIX) present at ASH 2025?

Nurix will present NX-5948-301 Phase 1a/1b updated clinical data: an oral CLL presentation, a Waldenström macroglobulinemia poster, and a BTK resistance poster.

When is the Nurix (NRIX) oral presentation on CLL at ASH 2025?

The oral CLL presentation is scheduled for December 6, 2025 at 9:45 a.m. ET.

When and where is the Nurix (NRIX) Waldenström poster presented at ASH 2025?

The Waldenström poster is scheduled for December 8, 2025, 6:00 p.m. ET at the Orange County Convention Center West Halls.

What new scientific topic will Nurix collaborators present at ASH 2025?

They will present mechanistic and structural data on pan-resistance to BTK therapies via the BTK A428D mutation on December 6, 2025 at 5:30 p.m. ET.

Which NX-5948 study is being reported by Nurix at ASH 2025?

Updated clinical findings come from the ongoing NX-5948-301 Phase 1a/1b trial.