Welcome to our dedicated page for Nurix Therapeutics news (Ticker: NRIX), a resource for investors and traders seeking the latest updates and insights on Nurix Therapeutics stock.
Nurix Therapeutics, Inc. (Nasdaq: NRIX) is a clinical-stage biopharmaceutical company developing targeted protein degradation medicines in oncology, autoimmune disease and inflammatory conditions. The NRIX news feed on Stock Titan aggregates company announcements, clinical updates and regulatory disclosures so readers can follow how its pipeline and collaborations evolve over time.
News about Nurix frequently centers on clinical trial results and milestones for its lead programs. Recent releases describe new and updated data from Phase 1a/1b studies of the BTK degrader bexobrutideg (NX-5948) in relapsed or refractory chronic lymphocytic leukemia, small lymphocytic lymphoma and Waldenström macroglobulinemia, including objective response rates, durability of responses and safety findings. Additional updates cover translational and clinical data for NX-1607, an oral CBL-B inhibitor for solid tumors, highlighting immune activation, tumor microenvironment remodeling and disease control in heavily pretreated patients.
Investors and clinicians can also use the NRIX news page to track corporate and regulatory events such as the initiation of the pivotal DAYBreak CLL-201 Phase 2 study, plans for a confirmatory Phase 3 trial, expansion of bexobrutideg into autoimmune and inflammatory indications, and participation in major medical and investor conferences including the American Society of Hematology (ASH), the Society for Immunotherapy of Cancer (SITC) and the J.P. Morgan Healthcare Conference.
Nurix’s news flow further includes announcements on strategic collaborations and governance, such as progress in partnered STAT6 and IRAK4 degrader programs with Sanofi and Gilead, and board appointments that add drug development and commercialization experience. Bookmark this page to access a consolidated view of NRIX press releases and related coverage as the company advances its targeted protein degradation pipeline.
Nurix Therapeutics (NRIX) presented positive Phase 1a/1b clinical trial data for NX-5948 in treating chronic lymphocytic leukemia. The trial showed a 75.5% Objective Response Rate, increasing to 84.2% in patients with at least two disease assessments. The study included 60 heavily pretreated patients who received a median of four prior therapies.
The drug demonstrated effectiveness in patients with mutations associated with poor prognosis and BTK inhibitor resistance, including those with CNS involvement. NX-5948 showed a favorable safety profile across all doses tested, with common side effects including purpura/contusion, fatigue, and neutropenia. Responses were durable, with thirteen patients showing response beyond six months and five patients maintaining response past one year of treatment.
Nurix Therapeutics (NRIX) announced a webcast scheduled for December 9, 2024, at 8:15 p.m. PT to present new clinical data from its ongoing Phase 1a/1b trial of BTK degrader NX-5948. The presentation will feature Dr. Nirav N. Shah from the Medical College of Wisconsin, who will discuss trial results in patients with relapsed/refractory chronic lymphocytic leukemia (CLL). Company executives will outline the clinical development strategy for NX-5948 in both oncology and autoimmune indications, along with updates on other clinical stage programs.
Nurix Therapeutics (Nasdaq: NRIX), a clinical stage biopharmaceutical company focused on developing targeted protein modulation drugs for cancer and inflammatory diseases, has announced its participation in the Piper Sandler 36th Annual Healthcare Conference. Arthur T. Sands, M.D., Ph.D., president and CEO, will deliver a corporate update on December 3, 2024, at 2:30 p.m. ET in New York City. The presentation will be available via live webcast through the company's website, with the recording accessible for 30 days following the event.
Nurix Therapeutics (NRIX) has received PRIME designation from the European Medicines Agency for NX-5948, its selective BTK degrader, for treating relapsed or refractory chronic lymphocytic leukemia patients who have previously received BTK and BCL-2 inhibitor therapy. The PRIME designation, which provides enhanced support for promising medicines addressing unmet medical needs, was granted based on encouraging safety and efficacy data from ongoing Phase 1 trials. NX-5948 has shown potential activity against mutations resistant to current BTK inhibitors, with pivotal trials planned for 2025.
Nurix Therapeutics (NRIX) presented preclinical data for two autoimmune and inflammatory disease programs at ACR Convergence 2024. The first program, NX-5948, is an oral BTK degrader showing potential superiority over kinase inhibitors in inflammatory diseases. The second program, GS-6791, developed with Gilead Sciences, is an IRAK4 degrader for rheumatoid arthritis treatment.
Both compounds demonstrated strong efficacy in preclinical models. NX-5948 showed superior results in arthritis models and other inflammatory conditions, while GS-6791 exhibited robust dose-dependent efficacy in arthritis models with better cytokine response reduction compared to IRAK4 kinase inhibitors.
Nurix Therapeutics announced upcoming presentations of data from its BTK degrader programs, NX-5948 and NX-2127, at the 66th ASH Annual Meeting in December 2024. The presentations include two oral sessions and one poster presentation. The first oral presentation will discuss efficacy and safety results from an ongoing Phase 1a/b study of NX-5948 in relapsed/refractory CLL patients. The second oral presentation will focus on how NX-2127 and NX-5948 affect T cell functionality in CLL. Additionally, a poster presentation will showcase studies on BTK degradation as a therapeutic strategy for relapsed CNS lymphoma.
Nurix Therapeutics (NRIX), a clinical stage biopharmaceutical company focused on targeted protein modulation drugs for cancer and inflammatory diseases, has announced its participation in five major investor conferences in November 2024. The company's leadership team, including CEO Arthur T. Sands, CFO Hans van Houte, and CBO Jason Kantor, will attend:
- Truist BioPharma Symposium (NY, Nov 7)
- UBS Healthcare Conference (CA, Nov 12)
- Stephens Biotechnology Virtual Fireside Chats (Nov 14)
- Stifel Healthcare Conference (NY, Nov 18)
- Jefferies London Healthcare Conference (UK, Nov 21)
Webcasts for the UBS, Stifel, and Jefferies conferences will be available on Nurix's website for 30 days post-event.
Nurix Therapeutics (Nasdaq: NRIX) announced presentations at the 7th Annual TPD & Induced Proximity Summit, October 28-31, 2024, in Boston. The company will present new preclinical data on a brain-penetrant, pan-mutant B-Raf degrader and recent clinical data from the NX-5948 BTK degrader program.
Key presentations include:
- An orally bioavailable, brain-penetrant pan-mutant B-RAF degrader showing potent anti-tumor activity in multiple disease models
- Clinical activity of NX-5948 in CLL & NHL, demonstrating utility in relapsed/refractory B-cell malignancies, including cases with CNS involvement and BTK inhibitor resistance mutations
Nurix executives will also participate in panel discussions on strategic partnerships and the future of targeted protein degradation. The company aims to showcase its leadership in the field and the therapeutic potential of its targeted protein modulation approach.
Nurix Therapeutics presented positive results from its ongoing Phase 1a/1b clinical trial of NX-5948, an oral BTK degrader, in patients with relapsed/refractory Waldenstrom's macroglobulinemia (WM) at the 12th International Workshop on Waldenstrom's Macroglobulinemia. Key findings include:
- 77.8% objective response rate (7 of 9 evaluable patients)
- Durable responses deepening over time
- Two patients on treatment for over a year
- Tolerable safety profile consistent with overall population
- Responses observed regardless of MYD88 and CXCR4 mutation status
The trial included heavily pretreated patients with a median of 3 prior lines of therapy. These results support the advancement of NX-5948 into the ongoing Phase 1b expansion cohort, including patients previously treated with BTK inhibitors and those with Bing-Neel syndrome.
Nurix Therapeutics (Nasdaq: NRIX) has appointed Anil Kapur to its board of directors, effective October 15, 2024. Mr. Kapur brings over 25 years of executive experience in pharmaceutical and biotech companies across U.S. and international markets. His expertise in commercial operations and launching novel drugs in hematology and oncology is particularly relevant to Nurix's pipeline.
Mr. Kapur's notable achievements include launching blockbuster drugs Imbruvica and Darzalex while at Johnson & Johnson. He has held senior leadership positions at various companies, including Geron , Actinium Pharmaceuticals, and Bristol-Myers Squibb. Nurix is preparing to advance NX-5948 into pivotal clinical testing in 2025 and is planning for future commercialization.